Protein Analysis Reagents
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor I, C1
A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10μM for 16 h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) c
MilliporeSigma™ Calbiochem™ BEC, Hydrochloride
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).
MilliporeSigma™ Calbiochem™ eEF2K Inhibitor, A-484954
The eEF2K Inhibitor, A-484954, also referenced under CAS 142557-61-7, controls the biological activity of eEF2K Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Novus Biologicals™ Vismodegib Hedgehog inhibitor
May be dissolved in DMSO (200 mg/mL); or ethanol (10 mg/mL, warm)
MilliporeSigma™ Calbiochem™ (-)-Cytisine
A potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respective
MilliporeSigma™ Calbiochem™ TIRAP Inhibitor Peptide, Control, Cell-Permeable
The TIRAP Inhibitor Peptide, Control, Cell-Permeable serves as a control for TIRAP Inhibitor Peptide. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ PKA Inhibitor 5-24
The PKA Inhibitor 5-24, also referenced under CAS 99534-03-9, controls the biological activity of PKA.
MilliporeSigma™ Calbiochem™ MMP-3 Inhibitor II
The MMP-3 Inhibitor II, also referenced under CAS 161314-17-6, controls the biological activity of MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ InSolution™ Sirtinol
A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity
MilliporeSigma™ Calbiochem™ PknG Inhibitor
The PknG Inhibitor, also referenced under CAS 329221-38-7, controls the biological activity of PknG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor IV
A cell-permeable inhibitor of SKP2-dependent p27Kip1 ubiquitination. Selectively induces the accumulation SCFSKP2 substrates in multiple myeloma RPMI 8226 cells.
MilliporeSigma™ Calbiochem™ BMX/BTK Inhibitor II, QL47
A cell-permeable, highly potent, selective, irreversible inhibitor of BTK (IC50 = 6.6 nM).
MilliporeSigma™ Calbiochem™ InSolution™ Caspase-3 Inhibitor I, Cell-Permeable
The InSolution™ Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ MDM2 Antagonist, Nutlin-3, Racemic
The MDM2 Antagonist, Nutlin-3, Racemic, also referenced under CAS 548472-68-0, controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ InSolution™ Rac1 Inhibitor II, Z62954982
The InSolution™ Rac1 Inhibitor II, Z62954982, also referenced under CAS 1090893-12-1, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.