Bioactive Small Molecules
Medchemexpress LLC D-I03 | 688342-78-1 | 99.7% | 428.64 g/mol | C23H36N6S | 10MM 1ML
D-I03 is a small-molecule RAD52 inhibitor used in research to block RAD52-dependent single-strand annealing and D-loop formation. It is supplied as an off-white to light-yellow solid and as a ready-to-use 10 mM solution in DMSO, with high purity and recommended storage conditions for powder and solutions.
- Selective inhibition of RAD52-mediated ssDNA annealing.
- Demonstrated biochemical activity with reported IC50 and Kd values.
- Available as solid and as a 10 mM solution in DMSO for workflow flexibility.
- High purity suitable for research applications.
- Stable under recommended storage conditions for long-term use.
- Molecular formula C23H36N6S; molecular weight 428.64 g/mol.
Cayman Chemical ANTIBODY CP 775 146 5mg
A PPARα agonist; binds selectively to PPARα (Ki = 24.5 nM) over PPARβ and PPARγ (Kis = >10,000 nM); induces PPARα transcriptional activity in a reporter assay (EC50s = 57 and 284 nM for human and rat receptors, respectively, expressed in HepG2 cells); decreases plasma triglyceride levels in mice by 73% at 2 mg/kg per day for two days
Cayman Chemical ANTIBODY PD 117519 50mg
An adenosine receptor agonist; selectively binds to adenosine A2 receptors (IC50 = 30 µM) over A1 receptors (IC50 = 810 µM) in rat brain membranes; increases heart rate and decreases systolic blood pressure in normotensive dogs at 2 and 10 mg/kg
Medchemexpress LLC Bms-502 | 2407854-18-4 | 99.3% | 516.50 | C27H22F2N6O3 | 10 MG
BMS-502 is a small-molecule research compound that acts as a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ, intended for preclinical and in vitro studies. It is provided with analytical data and storage recommendations to support research use.
- Potent dual inhibition of DGK α and ζ (IC50 4.6 nM and 2.1 nM).
- High purity suitable for research use (≈99.3%).
- Molecular weight 516.50; chemical formula C27H22F2N6O3 for compound identification.
- Available in small mass pack sizes convenient for screening and assay work.
- Stable under recommended storage conditions (-20°C; solvent storage guidance provided).
Medchemexpress LLC (R)-BI-2852 | 2375482-49-6 | 97.3% | 516.59 g/mol | C31H28N6O2 | 50MG
(R)-BI-2852 is the R-enantiomer of a KRAS switch I/II-pocket inhibitor supplied for research use as an experimental control. It preferentially binds active KRAS mutants and disrupts GEF, GAP, and effector interactions, producing antiproliferative effects in KRAS-mutant cells. Supplied as a solid with high enantiomeric purity and recommended storage under inert atmosphere.
- High enantiomeric purity (97.3%)
- Molecular formula C31H28N6O2
- Molecular weight 516.59 g/mol
- Soluble in DMSO (≈55 mg/mL)
- Available in multiple package sizes, including 50 mg
- Store solid at 4°C under nitrogen
Medchemexpress LLC (Z)-3-((1H-indol-2-yl)methylene)-4-((4-hydroxypiperidin-4-yl)ethynyl)indolin-2-one | 00-00-0 | 98.2% | C24H21N3O2 | 10MG
SBI-581 is an orally active, selective serine-threonine kinase TAO3 inhibitor with a reported IC50 of about 42 nM. It affects TKS5α trafficking, inhibits invadopodia formation, and has shown antitumor activity with reasonable pharmacokinetics in mouse studies; the molecule also contains an alkyne group suitable for click chemistry applications.
- Selective TAO3 inhibition with potent activity (~42 nM).
- Promotes TKS5α accumulation in RAB11-positive vesicles.
- Inhibits invadopodia formation, reducing invasive behavior.
- Demonstrated in vivo activity and reasonable pharmacokinetics in mice.
- Contains an alkyne group compatible with copper-catalyzed click chemistry.
Medchemexpress LLC Cloransulam-methyl | 147150-35-4 | 99.4% | 429.81 g·mol⁻¹ | C15H13ClFN5O5S | 50MG
Cloransulam-methyl is a triazolopyrimidine sulfonanilide herbicide and analytical research standard that inhibits acetolactate synthase (ALS). It is used for studying ALS inhibition and for analytical testing related to herbicide residues and mode-of-action research. The solid material has documented solubility and storage profiles for laboratory use.
- Inhibits acetolactate synthase (ALS), useful for biochemical studies.
- Supplied as an analytical research standard suitable for laboratory testing.
- High purity appropriate for analytical and experimental applications.
- Soluble in DMSO at 16.67 mg/mL with ultrasonic warming to 60°C.
- Powder storage stability: -20°C for up to 3 years; defined solution stability at low temperatures.
- Molecular weight 429.81 g·mol⁻¹; formula C15H13ClFN5O5S.
Medchemexpress LLC HY-N0906 25mg Medchemexpress, Ginsenoside Rk3 CAS:364779-15-7 Purity:>98%
Medchemexpress, HY-N0906 25mg Ginsenoside Rk3 CAS:364779-15-7 Ginsenoside Rk3 is present in the roots Panax notoginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC50 of 14.24±1.30 μM in HepG2 cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Transient receptor potential canonical 5 (TRPC5) activator | 896684-04-1 | 99.8% | 10 MG
BTD is a selective transient receptor potential canonical 5 (TRPC5) activator. It can be utilized for research related to neurological diseases.
- Selective activator of transient receptor potential canonical 5 (TRPC5).
- Activates TRPC5 with EC50 values of 1.4 μM (fluorometric microwell Ca2+ influx analyses) and 1.3 μM (in whole cell patch clamp experiments).
- Activates TRPM8-expressing cells with an EC50 value of 20.6 μM.
- Capable of activating heteromeric channel complexes that include TRPC5 and its closely related channels.
![Medchemexpress LLC Imidodicarbonic acid 2-[6-nitro-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)-5-isoquinolinyl] ester | 1841444-11-8 | 98.0% | 505.52 | C26H27N5O6 | 10MM 1ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000239251.png-250.jpg)
Medchemexpress LLC Imidodicarbonic acid 2-[6-nitro-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)-5-isoquinolinyl] ester | 1841444-11-8 | 98.0% | 505.52 | C26H27N5O6 | 10MM 1ML
MK-6240 Precursor (CAS 1841444-11-8) is the synthetic precursor used to prepare [18F]-MK-6240, a tau-targeting positron emission tomography (PET) tracer for research applications. The material is provided as a powder (light yellow to yellow) and is also available as a prepared 10 mM solution in DMSO (1 mL). Certificate of analysis reports a high purity and confirms molecular weight and formula information; store the material per recommended conditions.
Cayman Chemical GIlterItInIb 5mg
A FLT3 inhibitor (IC50 = 5 nM for the wild-type enzyme); inhibits various FLT3 mutants (IC50s = 1.4-12.2 nM); also inhibits Axl and c-Kit (IC50s = 41 and 102 nM, respectively); decreases the viability of blast cells isolated from patients with relapsed AML in a concentration-dependent manner
Medchemexpress LLC a-D-Glucosamine pent 25g | 7784-54-5 | 25 G
α-D-Glucosamine pentaacetate (2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-α-D-glucopyranose) is an acetylated derivative of D-glucosamine used as a research reagent in glycobiology and related synthetic applications. The material is supplied as a solid with confirmed composition and batch-level quality testing.
- Acetylated derivative of D-glucosamine suitable for glycobiology research.
- Chemical name: 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-α-D-glucopyranose.
- Molecular formula C16H23NO10; molecular weight 389.35.
- Purity ≥97.0% by NMR according to batch certificate of analysis.
- Supplied as a 25 G solid package.
- Intended for research, synthesis, and analytical applications (not for human use).
Medchemexpress LLC Gamma-glutamylserine | 5875-35-4 | 98.4% | C8H14N2O6 | 10MG
γ-Glutamylserine is a small-molecule amino acid derivative that functions as a calcium receptor activator. Provided as a white to off-white solid with formula C8H14N2O6 (MW 234.21), it is used in research on calcium receptor signaling and disease models such as Parkinson's disease, diabetes, and obesity.
- High purity (98.4%).
- White to off-white solid appearance.
- Soluble in DMSO at 100 mg/mL; may require sonication.
- Stable when stored sealed at -80°C (powder) for up to 2 years.
- Suitable for in vitro research on calcium receptor activity and metabolic disease models.
Cayman Chemical ANTIBODY PF-299804 5mg
An irreversible pan-ErbB receptor tyrosine kinase inhibitor (IC50s = 6, 45.7, and 73.7 nM for ErbB1, ErbB2, and ErbB4, respectively); demonstrates antitumor activity in various tumor xenograft models expressing either wild-type ErbB or mutant ErbB family members that show resistance to first generation ErbB kinase inhibitors