Bioactive Small Molecules
Cayman Chemical VIldaglptIn carylc ACD 5mg
A major metabolite of vildagliptin; IC50 = 477 µM for DPP-4 in human Caco-2 cells; formed from hydrolysis of the cyano group on vildagliptin
![Medchemexpress LLC N-(furan-2-ylmethyl)-3-[4-[methyl(propyl)amino]-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide | 2313525-20-9 | 99.8% | C17H21F3N4O2S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261059.png-250.jpg)
Medchemexpress LLC N-(furan-2-ylmethyl)-3-[4-[methyl(propyl)amino]-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide | 2313525-20-9 | 99.8% | C17H21F3N4O2S | 10MG
SET2 is a research compound that functions as a selective TRPV2 antagonist used to investigate TRPV2-mediated signaling in biochemical and cell-based assays. It has documented inhibitory potency and has been used in studies of calcium signaling and cell migration.
- Selective TRPV2 antagonist (IC50 = 0.46 μM)
- Useful in biochemical and cell-based assays
- Reduces lysophosphatidic acid-induced cytosolic calcium increase
- Reported to suppress prostate cancer cell migration
- High purity suitable for research applications
- Molecular formula: C17H21F3N4O2S; molecular weight: 402.43 g/mol
- Available in multiple small-scale pack sizes for laboratory use
Cayman Chemical GlatIrameracetate 5mg
A mixture of synthetic polypeptides that prevents MBP to MCH class II molecules; increases oligodendrocyte and neuronal precursor cell proliferation
Medchemexpress LLC Avasopasem manganese | 435327-40-5 | 96.1% | 483.38 | 100 MG
Avasopasem manganese is a potent superoxide dismutase mimetic. It rapidly and specifically converts superoxide radicals to hydrogen peroxide, thereby arresting the initiation of damaging cascades.
- Potent superoxide dismutase mimetic
- Rapidly and specifically converts superoxide radicals to hydrogen peroxide
- Arrests the initiation of damaging cascades
- Used for research of severe oral mucositis and cancer
- Intended to interrupt severe oral mucositis pathogenesis
- Reduces duration, incidence, and severity of radiation-induced oral mucositis
Medchemexpress LLC IL-17A inhibitor 1 | 2452464-73-0 | MFCD34474218 | >98.0% | C24H27F5N8O4 | 10MG
LY3509754 is an orally active small-molecule inhibitor of interleukin-17A (IL-17A) developed by Eli Lilly. It exhibits low-nanomolar potency in biochemical and cell-based assays, has been evaluated in early-phase clinical studies, and is supplied for research use with documented purity and supporting analytical data.
- Potent IL-17A inhibition with low-nanomolar IC50 values.
- Demonstrated cellular activity in HT-29 and NHDF assays.
- Supplied for research use with documented purity greater than 98.0%.
- Orally active small-molecule chemical class appropriate for pharmacology studies.
- Supported by preclinical and Phase 1 clinical data for translational research.
Cayman Chemical ANTIBODY UsnIc AcId 5g
A lichen metabolite with antioxidant, anticancer, antifungal, antiprotozoal, and antimicrobial activities; reduces the number of indomethacin-induced gastric ulcers in rats through decreased lipid peroxidation and decreased myeloperoxidase activity; fungicidal against C. orthopsilosis and C. parapsilosis (IC80s = 7.8 and 15.6 μg/ml, respectively); bactericidal against vancomycin-resistant E. faecalis (MIC = 125 μg/ml); reduces L. amazonensis parasite loads by 72.3% in footpads of infected mice; reduces growth of cancer cells in vitro (IC50s = 48.5-199 μM)
Medchemexpress LLC Rezivertinib | 1835667-12-3 | 486.57 | 50 MG
Rezivertinib (BPI-7711) is an orally active, highly selective and irreversible third-generation EGFR tyrosine kinase inhibitor (TKI). It demonstrates high potency against common activation EGFR and resistance T790M mutations. Rezivertinib also exhibits excellent central nervous system (CNS) penetration and has antitumor activity.
- Orally active
- Highly selective
- Irreversible third-generation EGFR tyrosine kinase inhibitor
- Potent against common activation EGFR mutations
- Potent against resistance T790M mutations
- Excellent central nervous system (CNS) penetration
- Antitumor activity
Cayman Chemical ANTIBODY PSB-KD107 10mg
A GPR18 agonist (EC50 = 0.56 µM in a β-arrestin recruitment assay using CHO cells expressing the human receptor); selective for GPR18 over GPR55, as well as cannabinoid 1 (CB1) and CB2 receptors, at 10 µM but also binds to the adenosine A2A receptor (Ki = 0.33 µM for the rat receptor)
Medchemexpress LLC (R)-OP-1074 | 1443752-77-9 | 98.2% | 457.56 g/mol | C29H31NO4 | 10MG
(R)-OP-1074 is the R-enantiomer of OP-1074, a selective estrogen receptor degrader used as a research reagent to study estrogen receptor signaling in biochemical and cellular assays. It is provided as a high-purity small molecule (CAS 1443752-77-9) with recommended solubility in DMSO and intended for research use only.
- R-enantiomer isomer for use as a stereochemical control.
- Selective estrogen receptor degrader activity suitable for ERα and ERβ studies.
- High purity appropriate for biochemical and cellular assays.
- Available in small pack sizes for experimental testing.
- Soluble in DMSO for assay preparation.
- For research use only; not for human or clinical use.
TARGETMOL CHEMICALS INC EPZ031686 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer. purity: 97%
Selleck Chemical LLC Cl-amidine hydrochloride E4995-1MG
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor with IC50 values of 0 8 M 6 2 M and 5 9 M for PAD1 PAD3 and PAD4 respectively Cl-amidine hydrochloride induces apoptosis in cancer cells Cl-amidine hydrochloride induces microRNA (miR)-16 (miRNA-16 microRNA-16) expression and causes cell cycle arrest Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation and improves survival in a murine sepsis model[1][2][3][4][5]
Cayman Chemical ANTIBODY PIrlIndole 25mg
A selective and reversible MAO-A inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively); selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively); reverses the depressive-like effects induced by CMS, increases hippocampal cell proliferation, and reverses CMS-induced dendritic atrophy in granule neurons in rats; inhibits enterovirus-D68 and CV-B3; inhibits CV-B3 genome replication (EC50 = 7.7 µM)
Cayman Chemical AS-2444697hydrochlorIde 5mg
An IRAK4 inhibitor (IC50 = 21 nM); greater than 30-fold selective for IRAK4 over a panel of 146 kinases, but is less than 10-fold selective over PDGFRα, PDGFRβ, TrkA, TrkC, CLK1, Itk, and FLT3; inhibits IL-1β-induced IL-6 production and LPS-induced TNF-α production in cellular assays (IC50s = 250 and 47 nM, respectively); efficacious in rat models of adjuvant- and collagen-induced arthritis (ED50s = 2.7 and 1.6 mg/kg, respectively); reduces urinary protein excretion, the development of interstitial fibrosis and glomerulosclerosis, and renal mRNA expression of genes encoding IL-1β, IL-6, TNF-α, and CCL2 in the 5/6 nephrectomized rat model of chronic kidney disease from 0.3-3 mg/kg
Cayman Chemical ANTIBODY TBA-354 250mg
An antitubercular agent; active against clinical isolates of drug-resistant and -sensitive replicating M. tuberculosis (MICs = M. tuberculosis over M. scrofulaceum, M. gilvum, M. fortuitum, M. triviale, and M. smegmatis (MICs = >11.5 μM) but is active against M. bovis and M. kansasii (MICs = M. tuberculosis infection at 100 mg/kg per day
Medchemexpress LLC L-888607 (racemate) | 1030017-51-6 | 99.8% | 375.84 | 25 MG
L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist. It exhibits Ki values of 132 nM for DP1 and 17 nM for thromboxane A2 receptor (TP).
- Selective prostaglandin D2 receptor subtype 1 (DP1) antagonist.
- Ki values of 132 nM for DP1 and 17 nM for thromboxane A2 receptor (TP).
- For research use only.