Bioactive Small Molecules
American Radiolabeled Chemicals Inc NORGESTREL 3H 50UC
Norgestrel, D-15,16-3H 50uCi in ethanol, 1 mCi/ml, 50-70 Ci/mmol, M.W. 312.45, Shipped in Dry Ice, Exclusive
Cayman Chemical ANTIBODY AVN-492 10mg
An antagonist of the 5-HT6 receptor (Ki = 0.09 nM); selectively inhibits the 5-HT6 receptor over the 5-HT2B receptor (IC50s = 0.19 and 268 nM, respectively, in a radioligand binding assay); inhibits increases in cAMP levels induced by 5-HT in HEK293 cells expressing the 5-HT6 receptor (IC50 = 1.5 nM); increases the time spent in the open arms of the elevated plus maze in rats, indicating anxiolytic activity, at 0.2 mg/kg; prevents memory deficits induced by MK-801 in a passive avoidance test at 1 mg/kg
Cayman Chemical 9-TetrahydrocnabIorcol 5mg
An analytical reference standard that is structurally similar to known phytocannabinoids; the C1 homolog of ∆9-THC; intended for research and forensic applications
AdipoGen Glucosylglycerol
Natural chemical product. CAS 22160-26-5. Formula C9H18O8. MW 254.2. Enzymatically processed from natural succrose and glycerine. Glucosylglycerol belongs to the class of compatible solutes osmolytes. It is a non-toxic, non-irritating protective osmolyte responsible for the osmotic adaptation of blue-green algae, rhizobacteria and Pseudomonas and also found in the drought-resistant resurrection plant Myrothamnus flabellifolia. Glucosylglycerol protects its host against osmotic stress, heat, desiccation and UV. Glucosylglycerol is an animal free and protein-free low molecular weight stabilizer which is an excellent cryoprotector for proteins in vitro, especially antibodies. In vitro models and skin models demonstrate strong activity of glucosylglycerol on aged and stressed skin cells with rejuvenating, recovering and radical scavenging properties.
Medchemexpress LLC Ac-{Gly(N-me)}-Sar-Sar-Sar-Sar-Sar-Sar-Sar-Sar-Sar | 2857963-60-9 | 99.5% | 770.83 | 100 MG
Ac-{Gly(N-me)}-Sar-Sar-Sar-Sar-Sar-Sar-Sar-Sar-Sar is a decapeptide used for the preparation of antibody-drug conjugates.
- Conjugates hydrophobic camptothecin-based payloads to antibodies.
- Significantly enhances conjugate solubility and stability.
- Reduces aggregation at high drug-to-antibody ratios (DAR).
- Facilitates release of native, active drug payload upon cleavage.
Selleck Chemical LLC dimyristoyl lecithin E2870-5MG
dimyristoyl lecithin (DMPC) is a synthetic phospholipid used in liposomes 1 2-Dimyristoyl-sn-glycero-3-phosphocholine is used for the study of lipid monolayers and bilayers
Medchemexpress LLC (S)-AM-9022 | 2446872-47-3 | 99.9% | 578.67 | 1 MG
(S)-AM-9022 is the S-enantiomer of AM-9022. It is an orally active, potent, and selective KIF18A inhibitor, making it suitable for cancer research.
- S-enantiomer of AM-9022
- Orally active
- Potent and selective KIF18A inhibitor
- Suitable for cancer research
Medchemexpress LLC Methyl nicotinate | 93-60-7 | 99.9% | 1 G
Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator with analgesic activity. When applied topically to the skin, it causes local skin erythema. It is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain.
- Orally active vasodilator.
- Analgesic activity.
- Causes local skin erythema when applied topically.
- Used in over-the-counter topical preparations for muscle and joint pain.
- Promoted microvasodilation at 5 mg/mL/egg in a Chorioallantoic Membrane (CAM) model.
- Significantly reduced writhes induced by acetic acid in mice, showing similar analgesic effect to Aspirin at 10 mg/kg.
- Significantly prolonged latency of mice's response to thermal pain in a hot plate test.
Cayman Chemical 11 ZHexadecenyl2ArachIdo 5mg
A plasmalogen; serum levels are decreased in dogs with myxomatous mitral valve disease fed a diet including medium chain triglycerides, fish oil, carnitine precursors, magnesium, and antioxidants
Medchemexpress LLC N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide | 959151-50-9 | MFCD10567109 | 99.0% | 345.44 g/mol | C22H23N3O | 10 MG
PF 750 is a selective, covalent inhibitor of fatty acid amide hydrolase (FAAH) used in biochemical and cellular research. It shows reported FAAH IC50 values of 16.2-595 nM depending on assay conditions. The compound is supplied as a solid of high purity and is intended for in vitro studies when prepared in appropriate solvents such as DMSO.
- Selective covalent FAAH inhibitor with reported IC50 16.2-595 nM.
- High purity (≈99.0%) suitable for research applications.
- Molecular weight 345.44 g/mol; formula C22H23N3O.
- Soluble in DMSO at 100 mg/mL; ultrasonic treatment recommended.
- Powder storage: -20°C (stable up to 3 years).
- In-solution storage: -80°C for 6 months or -20°C for 1 month.
- Available in small milligram quantities for research use.
Medchemexpress LLC Dinoprost (tromethamine salt) | 38562-01-5 | 98.0% | 50 MG
Dinoprost tromethamine salt is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. It is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL), playing a key role in the onset and progression of labor.
- Orally active
- Potent prostaglandin F (PGF) receptor (FP receptor) agonist
- Luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL)
- Plays a key role in the onset and progression of labor
- Induces ER stress, autophagy, and apoptosis in goat luteal cells
- Significantly increases the expression of GRP78 and UPR sensors
Medchemexpress LLC ASN02563583 | 483283-39-2 | 99.2% | 50 MG
ASN02563583 is a compound that modulates the activity of the GPR17 receptor, with an IC50 value of 0.64 nM in a [35S]GTPγS binding assay. It can be used in the study of neurological diseases.
- Modulates GPR17 receptor activity.
- Has an IC50 value of 0.64 nM in a [35S]GTPγS binding assay.
- Suitable for the study of neurological diseases.
- For research use only.
Cayman Chemical DIM-C-pPhCO2Me 10mg
An NR4A1 antagonist; decreases the expression of the mRNA encoding integrin β1 in MIA PaCa-2, PANC-1, RKO, and SW480 cells at 15 and 20 µM; decreases the migration and adhesion of MIA PaCa-2 and SW480 cells at 15 and 20 µM
Medchemexpress LLC Ferulenol | 6805-34-1 | MFCD02183471 | 99.0% | 366.49 g·mol⁻¹ | C24H30O3 | 5 MG
Ferulenol is a prenylated coumarin sesquiterpene derivative that specifically inhibits succinate ubiquinone reductase. It is supplied as a research reagent for in vitro and in vivo studies of mitochondrial metabolism and oxidative phosphorylation.
- High purity 99.0%.
- Chemical formula C24H30O3; molecular weight 366.49 g·mol⁻¹.
- Soluble ≥50 mg/mL in ethanol for in vitro use; suitable in vivo formulations reported.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Specifically inhibits succinate ubiquinone reductase, affecting mitochondrial oxidative phosphorylation.
- Available in small research sizes, such as 5 mg, 10 mg, and 50 mg.
Medchemexpress LLC Tmprss6-in-1 TFA | 00-00-0 | >98.0% | 790.88 g·mol⁻¹ | C35H41F3N8O6S2 | 5 MG
TMPRSS6-IN-1 TFA is a research-grade small-molecule inhibitor of TMPRSS6 (matriptase-2), supplied as the trifluoroacetic acid (TFA) salt. It is intended for in vitro biochemical and cell-based studies of serine/threonine protease activity and pathways related to iron homeostasis. Supplied as a solid in small milligram quantities; for research use only.
- Potent inhibitor of TMPRSS6 (matriptase-2).
- Supplied as the trifluoroacetic acid (TFA) salt for formulation convenience.
- High solubility in DMSO (125 mg/mL) enables concentrated stock solutions.
- Available in small milligram quantities suitable for screening and assay development.
- Store sealed and away from moisture; in solution: -80°C up to 6 months, -20°C up to 1 month.