Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,651 – 4,665 of 60,549 results

4,651

Cayman Chemical ML-243, Purity: ≥98%, CAS: 1426576-80-8, 5 mg

An inhibitor of cancer stem cells, displaying 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 2.0 µM) over a control (mammary epithelial) cell line (EC50 = 64 µM)

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4,652

Medchemexpress LLC Fenquizone | 20287-37-0 | MFCD00867349 | 99.6% | 337.78 g·mol^-1 | C14H12ClN3O3S | 10MM 1ML

Fenquizone is a thiazide-like diuretic research compound offered as a 10 mM solution in 1 mL DMSO or as a solid standard for analytical use. It has chemical formula C14H12ClN3O3S, molecular weight 337.78 g·mol^-1, and CAS number 20287-37-0. The product is intended for research use only and is not for human or veterinary use.

Thiazide-like diuretic useful for edema and hypertension research.
Available as a 10 mM solution in 1 mL DMSO and as a solid/standard format.
High purity (99.6%) suitable for analytical and research applications.
Molecular formula C14H12ClN3O3S and molecular weight 337.78 g·mol^-1.
Identified by CAS number 20287-37-0 for unambiguous reference.

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4,653

Medchemexpress LLC Isoxazolo-pyridinone 7e | 500164-74-9 | 99.7% | 390.43 | 50 MG

IP7e is a potent, brain-penetrant, and orally active Nurr1 activator. It is intended for research use only.

Activator of Nurr1 with an EC50 value of 3.9 nM.
Reduces incidence and severity of experimental autoimmune encephalomyelitis (EAE) in a murine model with preventive treatment.
Attenuates inflammation and neurodegeneration in spinal cords of EAE mice.
Acts through an NF-κB pathway-dependent process.

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4,654

Medchemexpress LLC SB-747651A dihydrochloride | 1781882-72-1 | 99.1% | 415.32 | 100 MG

SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor. It can be used for inflammation research, and also inhibits PRK2, RSK1, p70S6K, and ROCK-II.

Inhibits MSK1 with an IC50 of 11 nM.
Affects CXCL2-induced intraluminal crawling of neutrophils.
Thwarts intraluminal crawling of adherent neutrophils to optimal sites of emigration.
Significantly increases transmigration time and detachment time.
Inhibits the migration speed of extravascular chemotaxing neutrophils.

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4,655

Medchemexpress LLC Chlorphenoxamine | 77-38-3 | 99.2% | 10 MM * 1 ML

Chlorphenoxamine is an antihistamine and anticholinergic agent that acts as a GPCR antagonist. It has been shown to inhibit several lethal viral diseases, including SARS-CoV, MERS-CoV, EBOV, and malaria. It exhibits anti-filovirus activity against EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively.

Antihistamine and anticholinergic agent.
GPCR antagonist.
Inhibits multiple lethal viral diseases (SARS-CoV, MERS-CoV, EBOV, malaria).
Anti-filovirus activity against EBOV (IC50 of 1.1 μM) and Marburg virus (MARV) (IC50 of 6.2 μM).
Used for allergic conditions, urticaria, viral diseases, and Parkinson's disease.

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4,656

Cayman Chemical GSK2292767, Purity: ≥98%, CAS: 1254036-66-2, 5 mg

A potent and selective inhibitor of PI3Kδ (Ki = 79 pM); has >1,000-fold selectivity for PI3Kδ over isoforms PI3Kα, PI3Kβ, and PI3Kγ (Kis = 501, 630, and 501 nM, respectively); >100-fold selective for PI3Kδ over a panel of 250 kinases; inhibits IFNγ and IL-2 production (IC50s = 1.9 and 3.16 nM, respectively) in a human lung parenchyma assay; protects against eosinophil recruitment (ED50 = 35 μg/kg) in the brown Norway rat acute ovalbumin model of Th2-driven lung inflammation

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4,657

Cayman Chemical Oxfendazole, Purity: ≥98%, CAS: 53716-50-0, 5 mg

An anthelmintic; curative in pig models of H. rubidus or A. suum infection at 3 and 6 mg/kg, respectively; is lethal to H. contortus and T. circumcincta when administered to infected cattle (LD50s = 4.28 and 3.61 mg/kg of host weight, respectively)

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4,658

Cayman Chemical Cannabibutol, Purity: ≥98%, CAS: 60007-99-0, 5 mg

An analytical reference standard that is structurally similar to known phytocannabinoids; has been found in Cannabis; intended for research and forensic applications

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4,659

Cayman Chemical CX-4945, Purity: ≥98%, CAS: 1009820-21-6, 10 mg

A potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki = 0.38 nM); inhibits proliferation in a panel of cancer cell lines that overexpress CK2 and prevents tumor growth of breast and pancreatic cancer cell xenografts in mice

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4,660

AdipoGen T0901317 (10 mg)

Chemical. CAS: 293754-55-9. Formula: C17H12F9NO3S. MW: 481.3. T0901317 is a potent, cell permeable and selective agonist of LXRalpha and LXRbeta. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol and regulation of HDL metabolism. T0901317 activates farnesoid X receptor (FXR) (EC50 ~5µM), less potent then LXR, but activates FXR more potently than a natural bile acid FXR ligand, chenodeoxycholic acid. It also is a high-affinity ligand for the xenobiotic receptor pregnane X receptor (PXR). T0901317 binds and activates PXR with the same nanomolar potency with which it stimulates LXR activity. T0901317 shows anti-atherosclerosis, antidiabetic, insulin sensitizing, anticancer, anti-proliferative, metabolism modulating and neuroprotective properties.

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4,661

Medchemexpress LLC HY-N6626 100mg Medchemexpress, Pyraclostrobin CAS:175013-18-0 Purity:>98%

Medchemexpress, HY-N6626 100mg Pyraclostrobin CAS:175013-18-0 Pyraclostrobin is a strobilurin fungicide that inhibits mitochondrial complex III of fungal and mammalian cells. Pyraclostrobin induces triglyceride accumulation and triglyceride accumulation in 3T3-L1 cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4,662

Cayman Chemical Poliumoside, Purity: ≥95%, CAS: 94079-81-9, 5 mg

A phenylethanoid glycoside; scavenges DPPH and ABTS radicals (IC50s = 10.9 and 19.9 µM), as well as inhibits the activity of PKCα (IC50 = 24.4 µM), in cell-free assays); reduces LPS-induced production of TNF-α and IL-6 in RAW 264.7 cells from 12.5-100 µM; decreases glutamate-induced cytotoxicity in primary rat cortical neurons at 0.1, 1, or 10 µM

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4,663

Med Vet International Zoetis Lutalyse, 5mg/mL, 100mL

VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED

Dinoprost tromethamine sterile solution, used as a luteolytic agent in cattle, parturition induction in swine, and luteolytic effect in mares.

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4,664

Cayman Chemical C17 Ceramide (d18:1/17:0), Purity: ≥98%, CAS: 67492-16-4, 5 mg

A synthetic ceramide; contains a non-natural C17:0 fatty acid acylated to sphingosine; has been used as a marker of arylsulfatase A and sphingolipid activator B activity

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4,665

Cayman Chemical A286982, Purity: ≥98%, CAS: 280749-17-9, 10 mg

An inhibitor that blocks the integrin-ligand interaction between LFA-1 and ICAM-1 (IC50 = 35 nM); inhibits adhesion of JY-8 cells to ICAM-1-coated microtiter plates (IC50 = 44 nM)

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Medchemexpress LLC Fenquizone | 20287-37-0 | MFCD00867349 | 99.6% | 337.78 g·mol^-1 | C14H12ClN3O3S | 10MM 1ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Isoxazolo-pyridinone 7e | 500164-74-9 | 99.7% | 390.43 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SB-747651A dihydrochloride | 1781882-72-1 | 99.1% | 415.32 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Chlorphenoxamine | 77-38-3 | 99.2% | 10 MM * 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-N6626 100mg Medchemexpress, Pyraclostrobin CAS:175013-18-0 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Fenquizone | 20287-37-0 | MFCD00867349 | 99.6% | 337.78 g·mol^-1 | C14H12ClN3O3S | 10MM 1ML

Medchemexpress LLC Isoxazolo-pyridinone 7e | 500164-74-9 | 99.7% | 390.43 | 50 MG

Medchemexpress LLC SB-747651A dihydrochloride | 1781882-72-1 | 99.1% | 415.32 | 100 MG

Medchemexpress LLC Chlorphenoxamine | 77-38-3 | 99.2% | 10 MM * 1 ML

Medchemexpress LLC HY-N6626 100mg Medchemexpress, Pyraclostrobin CAS:175013-18-0 Purity:>98%