Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,696 – 4,710 of 60,549 results

4,696

Cayman Chemical ANTIBODY CAY10662 25ug

A 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 μM CAY10662 exerts weak dose-dependent sEH inhibition

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4,697

Cayman Chemical BZAD-01, Purity: ≥98%, CAS: 305339-41-7, 25 mg

An antagonist of NR2B subunit-containing NMDA receptors (Ki = 72 nM); selective for NR2B subunit-containing NMDA receptors over those containing NR2A subunits (IC50s = 47 and >10,000 nM, respectively); reduces carrageenan-induced hyperalgesia in rats (ED50 = 5.5 mg/kg); reduces dopaminergic neuron loss in the rat substantia nigra pars compacta and improves measures of ipsilateral curling, ipsilateral head positioning, and beam walking in a rat model of 6-OHDA-induced Parkinson’s disease at 10 mg/kg

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4,698

Cayman Chemical NSC 87877, Purity: ≥98%, CAS: 56990-57-9, 50 mg

A cell-permeable, potent inhibitor of both SHP-1 and SHP-2 (IC50 = 355 and 318 nM, respectively); much less effective against other protein tyrosine phosphatases and DUSP26

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4,699

Cayman Chemical Ko 143, Purity: ≥98%, CAS: 461054-93-3, 5 mg

A potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC50s = 23 and 26 nM, respectively); effective in vivo in mice

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4,700

Cayman Chemical MMDPPO, Purity: ≥98% (mixture of isomers), CAS: 146322-08-9, 1 mg

An analytical reference standard categorized as an amphetamine; an intermediate in the synthesis of (±)-MDA; intended for research and forensic applications

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4,701

Perkin Elmer US LLC 19 ga. Custodion CME Sampling Device with 3 Replacement Coils

Sampling just got easier - Simplify your collection devices to save time obtaining field samples by investing in CME technology. CME is ideal for liquids including explosives, accelerants, drugs of abuse and, semi-volatiles. This novel technique consisting of a finely coiled wire that traps liquid samples by capillary action. When used with the Torion T-9 Portable GC/MS, in-field sample analysis is quick, easy, and reliable.

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4,702

AdipoGen Umbelliferon (100 g)

Chemical. CAS: 93-35-6. Formula: C9H6O3. MW: 162.14. Synthetic. Umbelliferone is a naturally occurring derivative and metabolite of coumarin that has diverse biological activities including antitumor, antioxidant, antihyperglycemic, anti-inflammatory, neuroprotective and antidepressant-like properties. It inhibits the growth of a variety of human cell lines. It increases the production of reactive oxygen species (ROS), depolarizes the mitochondrial membrane, and halts the cell cycle at the G0/G1 phase in KB human oral carcinoma cells. Umbelliferone has been used as a ratiometric pH indicator. Spectral Data: Em=460nm / Ex=330(ph<6)/370nm(pH>8). Umbelliferone can also be used as building block to synthesize fluorescent probes or biochemically active APIs.

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4,703

Medchemexpress LLC 5-bromo-3-iodo-4-azaindole | 1190319-16-4 | 99.4% | 322.93 | C7H4BrIN2 | 100 MG

5-bromo-3-iodo-4-azaindole is a halogenated azaindole used as a chemical intermediate in medicinal chemistry and small-molecule synthesis. It is supplied as a solid and intended for research and synthetic applications.

High purity suitable for synthesis and characterization.
Halogenated azaindole scaffold useful for cross-coupling and functionalization.
Solid appearance typically light brown to brown.
Suitable for laboratory-scale synthesis and intermediate-stage transformations.

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4,704

Cayman Chemical AMG 319, Purity: ≥98%, CAS: 1608125-21-8, 5 mg

A potent, selective inhibitor of PI3Kδ (IC50 = 18 nM); blocks anti-IgM/CD40L-induced proliferation (IC50 = 8.6 nM) and reduces Akt phosphorylation (IC50 = 1.5 nM) in B cells; reduces inflammation in two animal models

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4,705

Cayman Chemical Picrotin, Purity: ≥98%, CAS: 21416-53-5, 100 mg

A natural antagonist of GlyRs (IC50s = 57 and 117 µM for α1 and α2 homodimeric GlyRs, respectively); does not inhibit GABAA or GABAC receptors

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4,706

Cayman Chemical Teicoplanin A2-5, Purity: ≥95%, CAS: 91032-38-1, 5 mg

A non-polar glycopeptide antibiotic produced by A. teichomyceticus that is broadly effective against Gram-positive bacteria

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4,707

Cayman Chemical CJ-13610, Purity: ≥98%, CAS: 179420-17-8, 10 mg

An inhibitor of 5-LO (IC50 = 70 nM for 5-LO product formation in A23187-challenged PMNLs); inhibits recombinant 5-LO in a glutathione peroxidase-dependent manner (IC50 = 300 nM); reduces levels of LTB4 and decreases mechanical hyperalgesia in a rat model of chronic inflammatory pain induced by Freund's adjuvant (3-10 mg/kg); reverses tactile allodynia and increases hind paw weight bearing in a rat medial meniscal transection model of osteoarthritic pain (0.6-6 mg/kg)

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4,708

Medchemexpress LLC Cis-piperidine-2,3-dicarboxylic acid | 46026-75-9 | >98.0% | 50 MG

Cis-piperidine-2,3-dicarboxylic acid is a research reagent that modulates ionotropic glutamate receptors. It functions as a non-specific antagonist of NMDA, AMPA, and kainate receptors and as a partial agonist at NMDA receptors, and is used to block or study excitatory synaptic transmission in neuropharmacology experiments.

Acts as a non-specific antagonist of NMDA, AMPA, and kainate receptors.
Exhibits partial agonist activity at NMDA receptors for modulation studies.
High purity (≥98.0%) suitable for research applications.
Soluble in water (≈100 mg/mL) with ultrasonic assistance.
Off-white to light yellow solid stored at 4°C and protected from light.

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4,709

Selleck Chemical LLC Pexidartinib Hydrochloride E6007-100MG

Pexidartinib Hydrochloride is an oral tyrosine kinase inhibitor of colony-stimulating factor 1 receptor (CSF1R) It significantly reduces macrophage levels in adipose tissue without altering overall myeloid cell counts in mice It also induces developmental and immunotoxic effects in zebrafish embryos by hyperactivating Wnt signaling

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4,710

Apexbio Technology LLC (+)-MK 801(Synonyms: Dizocilpine, Dizocilpine maleate, MK-801, (+)-MK-801, (+)-Dizocilpine), 10mg, CAS: 70449-94-4.

( )-MK 801 (CAS 70449-94-4) is a potent selective and non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor displaying a Ki of approximately 30 5 nM This small molecule readily crosses the blood-brain barrier and interacts reversibly with specific binding sites on cortical membranes predominantly localized within the hippocampus In vitro assays utilizing rat cortical slice preparations indicate that ( )-MK 801 robustly inhibits NMDA-induced depolarization events and suppresses epileptiform activity mediated by neurotoxic agents Due to these pharmacological properties ( )-MK 801 is utilized experimentally in neuroscience research to study NMDA receptor-mediated events neurotoxicity convulsions and excitatory neurotransmission pathways

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Medchemexpress LLC 5-bromo-3-iodo-4-azaindole | 1190319-16-4 | 99.4% | 322.93 | C7H4BrIN2 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cis-piperidine-2,3-dicarboxylic acid | 46026-75-9 | >98.0% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5-bromo-3-iodo-4-azaindole | 1190319-16-4 | 99.4% | 322.93 | C7H4BrIN2 | 100 MG

Medchemexpress LLC Cis-piperidine-2,3-dicarboxylic acid | 46026-75-9 | >98.0% | 50 MG