Bioactive Small Molecules
Selleck Chemical LLC paquinimod S9963-10MM/1ML
Paquinimod (ABR 25757) a specific inhibitor of S100A8/A9 could rescue the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice
Selleck Chemical LLC AG-636 S9776-25MG
AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity
Selleck Chemical LLC paquinimod S9963-1G
Paquinimod (ABR 25757) a specific inhibitor of S100A8/A9 could rescue the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice
Medchemexpress LLC IOWH-032 | 1191252-49-9 | 99.6% | 545.18 | 5 MG
IOWH-032 is a synthetic anti-secretory molecule and a potent CFTR inhibitor with an IC50 value of 8 μM. It also functions as an anti-diarrheal agent.
- Potent CFTR inhibitor with an IC50 value of 8 μM.
- Acts as an anti-diarrheal agent.
- Increases ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells.
Medchemexpress LLC B-Raf IN 1 | 950736-05-7 | 99.9% | 515.53 | 1 ML
B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM. It is for research use only and appears as a light yellow to yellow solid.
- Potent and selective B-Raf kinase inhibitor
- IC50 of 24 nM for B-Raf
- Appears as a solid
- Light yellow to yellow color
- For research use only
Medchemexpress LLC Difluprednate | 23674-86-4 | 99.6% | 508.55 | 50 MG
Difluprednate is a glucocorticoid receptor (GC receptor) agonist with a Ki of 0.78 nM. Its active metabolite, 21-deacetylated difluprednate (DFB), is a competitive agonist of GC receptors with a Ki of 0.061 nM. It binds to GC receptors through metabolism to DFB, regulating the transcription of inflammatory mediator genes, thereby exerting anti-inflammatory activity. It can be used for research related to ocular inflammation, such as postoperative inflammation and anterior uveitis.
- Glucocorticoid receptor (GC receptor) agonist
- Active metabolite DFB is a competitive agonist of GC receptors
- Regulates transcription of inflammatory mediator genes
- Exerts anti-inflammatory activity
- Used for research related to ocular inflammation, such as postoperative inflammation and anterior uveitis
Medchemexpress LLC (R)-thalidomide | 2614-06-4 | 99.8% | 258.23 g/mol | C13H10N2O4 | 5 MG
(R)-Thalidomide is the R-enantiomer of thalidomide supplied as a high-purity research reagent. It is described as having psychomotor-stabilizing properties and is provided as a white to off-white solid for biochemical and pharmacological studies (research use only).
- R-enantiomer of thalidomide.
- High purity (99.8%).
- White to off-white solid appearance.
- Molecular formula C13H10N2O4; molecular weight 258.23 g/mol.
- Provided for biochemical and pharmacological research use only.
Medchemexpress LLC Mpro inhibitor N3 | 884650-98-0 | 99.8% | 680.79 g·mol⁻¹ | C35H48N6O8 | 5 MG
Mpro inhibitor N3 is a peptide-based inhibitor of the SARS-CoV-2 main protease (MPro) used as a biochemical and antiviral research reagent. It has a reported EC50 of 16.77 μM against SARS-CoV-2 and shows antiviral activity versus HCoV-229E, FIPV, IBV, and MHV-A59; molecular formula C35H48N6O8 and molecular weight 680.79 g·mol⁻¹.
- Inhibits SARS-CoV-2 main protease (MPro).
- Reported EC50 of 16.77 μM against SARS-CoV-2.
- Demonstrates antiviral activity against multiple coronaviruses.
- High reported purity (99.76%).
- Suitable for biochemical assays and antiviral research.
- Available in small-mass research quantities for laboratory use.
Apexbio Technology LLC BAY 60-6583 910487-58-0 5mg
BAY 60-6583 is a potent and selective agonist targeting the adenosine A2B receptor a G-protein-coupled receptor activated by elevated extracellular adenosine It is designed to activate the A2B receptor thereby stimulating cAMP production and modulating intracellular signaling pathways BAY 60-6583 exerts its biological activity primarily through promotion of cAMP-mediated signaling influencing gene transcription associated with glucocorticoid-response and cAMP-response elements In various cell-based assays BAY 60-6583 activates A2B receptor-dependent responses promoting the expression of anti-inflammatory genes such as CD200 CRISPLD2 and SOCS3 Based on these pharmacological properties BAY 60-6583 holds research potential in cardiovascular protection and inflammation-focused studies
Medchemexpress LLC Heparin sodium salt | 9041-08-1 | 100 MG
Heparin sodium salt (Sodium heparin) is an anticoagulant that reversibly binds to antithrombin III (ATIII), significantly accelerating the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. It also notably inhibits exosome-cell interactions.
- Reversibly binds to antithrombin III (ATIII)
- Accelerates ATIII inactivation of thrombin factor IIa and factor Xa
- Inhibits exosome-cell interactions
Medchemexpress LLC BMS-986141 | 1478711-48-6 | MFCD35066220 | C27H23N5O5S2 | 25 MG
BMS-986141 is an orally active, selective thrombin receptor protease-activated receptor-4 (PAR-4) antagonist with an IC50 value of 0.4 nM. It demonstrates excellent antithrombotic effects.
- Orally active and selective PAR-4 antagonist
- Demonstrates excellent antithrombotic effects
- IC50 value of 0.4 nM for PAR-4
- Inhibits platelet aggregation induced by PAR4 agonist peptide
- Effective in animal models for anti-thrombotic activity
- Involved in clinical trials for various thrombotic and cardiovascular conditions
Medchemexpress LLC Org 274179-0 | 1421683-12-6 | C28H27F3N2O2 | 25 MG
Org 274179-0 is a potent and allosteric antagonist of the thyroid-stimulating hormone (TSH) receptor, with an IC50 of nanomolar concentration. It completely inhibits TSH (and TSI)-mediated TSH receptor activation with minimal impact on the potency of TSH. This product is suitable for research related to Graves' disease (GD).
- Potent and allosteric antagonist of TSH receptor
- Completely inhibits TSH (and TSI)-mediated TSH receptor activation
- Minimal impact on TSH potency
- Suitable for Graves' disease research
- Purity: 98.63%
- Appearance: solid
- Color: light yellow to yellow
- Solubility in DMSO: 100 mg/mL
Medchemexpress LLC (S)-Veludacigib | 2732902-09-7 | C20H19FN4O3S | 25 MG
(S)-BAY 2965501 is the left-handed isomer of BAY 2965501 (HY-153343). It is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation and can be used for cancer research.
- Potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor
- Induces pERK activation
- Can be used for the research of cancer
Medchemexpress LLC 2-Hydroxy-4-methoxybenzaldehyde | 673-22-3 | 152.15 | 250 G
2-Hydroxy-4-methoxybenzaldehyde is a potent tyrosinase inhibitor and an isomer of Vanillin. It can be used in the synthesis of Urolithin M7 and inhibits the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase with an ID50 of 4.3 μg/mL (0.03 mM).
- Potent tyrosinase inhibitor
- Isomer of Vanillin
- Used in the synthesis of Urolithin M7
- Inhibits L-DOPA oxidation by mushroom tyrosinase
Medchemexpress LLC 1,2,4,5-tetrachloro-3-nitrobenzene | 117-18-0 | >98.0% | 500 MG
Tecnazene (1,2,4,5-tetrachloro-3-nitrobenzene) is an organochlorine fungicide used as a sprout inhibitor for stored potatoes and as an intermediate in specialty chemical synthesis. It is supplied for laboratory use in solid powder form and as DMSO solutions for research applications.
- High purity >98.0% (GC).
- Molecular weight 260.89 g·mol⁻¹.
- Chemical formula C6HCl4NO2.
- Available as solids (100 mg, 250 mg, 500 mg, 1 g) and as 10 mM solution in DMSO.
- Suitable for use as a sprout inhibitor and as a building block in specialty chemical synthesis.