Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,786 – 4,800 of 60,549 results

4,786

Cayman Chemical ANTIBODY NVP-BEP800 500ug

An Hsp90 inhibitor (IC50 = 58 nM for recombinant human Hsp90β); selective for Hsp90 over GRP94 and TRAP1 (IC50s = 4.1 and 5.5 µM, respectively); inhibits the growth of BT474, SK-BR-3, MCF-7, MDA-MB-157, MDA-MB-231, MDA-MB-468, and BT-20 breast cancer cells (GI50s = 53, 56, 118, 89, 190 173, and 162 nM, respectively); reduces levels of HER2 and Raf-1 in MCF-7 cells; induces apoptosis and attenuates X-ray-induced increases in Hsp70 levels in T98G glioblastoma cells; reduces tumor volume in A375 melanoma and BT474 breast cancer mouse xenograft models from 15-50 mg/kg; reduces tumor volume in an L1T2 Kaposi sarcoma mouse xenograft model

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4,787

Selleck Chemical LLC A2AR antagonist 1 5mg 443103-97-7

A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.

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4,788

Medchemexpress LLC Nonabine | 16985-03-8 | 100.0% | 379.54 | C25H33NO2 | 1MG

Nonabine is a synthetic cannabinoid research compound with antiemetic activity that functions as a CB1 receptor agonist in the brainstem and enteric nervous system. It is supplied as a white to off-white solid for laboratory and pharmacology research.

Provides CB1 receptor activation relevant to antiemetic studies.
Suitable for in vitro and in vivo pharmacology research.
High reported purity (99.95%).
White to off-white powder form for accurate dosing.
Stable when stored as powder at -20°C for up to 3 years.
Available in small research quantities for dose-ranging studies.

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4,789

Cayman Chemical BT-11, Purity: ≥98%, CAS: 1912399-75-7, 5 mg

A LANCL2 pathway activator; binds to LANCL2 (Kd = 7.7 µM); increases cAMP levels in mouse splenocytes isolated from wild-type, but not Lancl2-/-, mice at 5 and 10 µM; reduces leukocyte infiltration, epithelial erosion, and mucosal thickening in the colon in a mouse model of DSS-induced colitis at 8 mg/kg; reduces histopathological changes in wild-type mice in a model of DSS-induced colitis but not in mice with a T cell-specific conditional knockout of Lancl2

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4,790

Cayman Chemical Daurisoline, Purity: ≥98%, CAS: 70553-76-3, 5 mg

An alkaloid with diverse biological activities; enhances camptothecin-induced cytotoxicity in HeLa cells at 10 µM; inhibits camptothecin-induced autophagy in HeLa, A549, and HCT116 cells (IC50s = 74.75, 50.54, and 80.81 μM, respectively); inhibits ADP-induced aggregation of platelets in isolated rabbit whole blood (IC50 = 100 µM); prolongs APD and reduces EADs in papillary muscle preparations isolated from hypertrophied rabbit hearts at 15 µM

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4,791

Medchemexpress LLC Bendroflumethiazide-d5 | 1330183-13-5 | 98.6% | 1 MG

Bendroflumethiazide-d5 is a deuterium-labeled version of Bendroflumethiazide, an orally available diuretic. It functions by inhibiting the electroneutral sodium-chloride symporter in the distal convoluted tubule, effectively lowering blood pressure. This compound is valuable in the study of hypertension and edema, and demonstrates an antidiuretic effect in diabetes insipidus.

Can be used as a tracer.
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.

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4,792

Selleck Chemical LLC Z57346765 hydrochloride E8275-1G

Z57346765 hydrochloride is an inhibitor of phosphoglycerate kinase 1 (PGK1) that binds to the ADP-binding pocket with a KD value of 2 09 10 M reducing PGK1 metabolic enzyme activity glucose consumption and lactate production It also inhibits DNA replication impairs DNA damage repair and induces cell cycle arrest in kidney renal clear cell carcinoma (KIRC) cells

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4,793

Medchemexpress LLC Nicotinohydrazide | 553-53-7 | 99.35% | 137.14 | 1 ML

Nicotinohydrazide (Nicotinic acid hydrazide) is a small molecular compound intended for research use.

Small molecular compound
For research use only

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4,794

Medchemexpress LLC HY-134823 5mg , MD-222 CAS:2136246-72-3 Purity:>98%

HY-134823 5mg MD-222 CAS: 2136246-72-3 MD-222 is the first-in-class highly potent PROTAC degrader of MDM2. MD-222 consists of ligands for Cereblon and MDM2. MD-222 induces rapid degradation of the MDM2 protein and activation of wild-type p53 in cells. MD-222 has anticancer effects. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4,795

Medchemexpress LLC 2-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one | 877963-94-5 | MFCD07849042 | 98.0% | 317.41 g/mol | C16H19N3O2S | 100 MG

LOC14 is a small-molecule inhibitor of protein disulfide isomerase (PDI) used in biochemical and cellular research to probe PDI activity and related pathways. It is supplied as a white to off-white solid with available solubility and in vivo formulation guidance for experimental use.

Potent PDI inhibitor used to study disulfide isomerase activity.
High purity (98.0%).
White to off-white solid suitable for analytical and biological assays.
Molecular weight 317.41 g/mol; formula C16H19N3O2S.
Soluble in DMSO; in vivo formulations and solubility data available.
Store at 4°C and prepare solutions fresh due to instability in solution.

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4,796

Cayman Chemical BCI-121, Purity: ≥98%, CAS: 432529-82-3, 10 mg

An inhibitor of SMYD3; inhibits H3K4 di- and trimethylation in HT-29 cell lysates at 100 µM; inhibits proliferation in a panel of colorectal, lung, pancreatic, prostate, and ovarian cancer cell lines in an SMYD3 expression-dependent manner; induces cell cycle arrest at the S phase and decreases global H5K4 methylation and H3K4 dimethylation in HT-29 cells; intratumoral injection reduces tumor volume in an MHCC97H HCC mouse xenograft model at 20 µM

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4,797

Cayman Chemical Pencycuron, Purity: ≥95%, CAS: 66063-05-6, 500 mg

A phenylurea fungicide; active against the plant pathogenic fungi G. graminis, R. oryzae, and R. solani, but not P. intermedium or P. irregulare, at 10 µg/ml; reduces the incidence of R. solani-induced sheath blight on rice at 125, 250, and 500 ppm

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4,798

Medchemexpress LLC (S)-BRD9500 | 1630760-76-7 | 99.5% | C15H18FN3O2 | 5 MG

(S)-BRD9500 is the S-enantiomer of BRD9500 provided for research use as an experimental control in studies of phosphodiesterase 3 (PDE3) inhibition. It is supplied in small quantities for in vitro and in vivo assays, with storage and purity specifications suitable for laboratory workflows.

S enantiomer used as an experimental control in PDE3 inhibition studies.
High reported purity (~99.5% by HPLC).
Molecular formula C15H18FN3O2 and molecular weight 291.32 g·mol-1.
Available in small research quantities (1 mg, 5 mg, 10 mg).
Store powder at -20°C long term or 4°C short term; store solutions at -80°C long term.

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4,799

Cayman Chemical 5-fluoro PB-22 8-hydroxyisoquinoline isomer, Purity: ≥98%, CAS: 2365470-99-9, 5 mg

Differs from 5-fluoro PB-22 by having the quinoline group replaced with an isoquinoline group attached at its eight position; intended for forensic and research purposes

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4,800

Medchemexpress LLC Adam9 protein, mouse (HEK293, His tag) | 90.0% | 50 UG

Recombinant mouse ADAM9 protein expressed in HEK293 cells with a C-terminal His tag, supplied as a 50 μg research-grade aliquot. Intended for biochemical assays, antibody validation, and cell-signaling studies. Purity is listed as 90%; formulation or buffer is not specified in available listings.

Recombinant mouse ADAM9 protein expressed in HEK293 cells.
C-terminal His tag for detection and purification.
Pack size approximately 50 μg in a research-grade aliquot.
Purity reported as 90%.
Suitable for biochemical assays and antibody validation.
Formulation or buffer not specified in product listings.

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Bioactive Small Molecules

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Medchemexpress LLC Nonabine | 16985-03-8 | 100.0% | 379.54 | C25H33NO2 | 1MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Bendroflumethiazide-d5 | 1330183-13-5 | 98.6% | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Nicotinohydrazide | 553-53-7 | 99.35% | 137.14 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-134823 5mg , MD-222 CAS:2136246-72-3 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one | 877963-94-5 | MFCD07849042 | 98.0% | 317.41 g/mol | C16H19N3O2S | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S)-BRD9500 | 1630760-76-7 | 99.5% | C15H18FN3O2 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Adam9 protein, mouse (HEK293, His tag) | 90.0% | 50 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More