Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical SGC0946 (trifluoroacetate salt), Purity: ≥98%, 5 mg
A DOT1L inhibitor (IC50 = 0.3 nM); selective for DOT1L over a panel of 12 additional protein methyltransferases, DNMT1, and a panel of 29 receptors and ion channels; reduces H3K79me2 levels in MCF-10A breast cancer cells (IC50 = 8.8 nM); selectively reduces the viability of isolated human cord blood cells transformed with an MLL-AF9 fusion oncogene over those transformed with a TLS-ERG fusion oncogene at 1 and 5 µM; adoptive transfer of isolated human CD3+ T cells pre-incubated with SGC0946 (0.5 µM) prevents weight loss, increases survival, and reduces hepatic and colonic lymphocyte infiltration in a xenogeneic mouse model GVHD
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Cayman Chemical MDMB-4en-PICA butanoic acid metabolite, Purity: ≥98%, 5 mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; a potential metabolite of MDMB-4en-PICA based on the published metabolism of MDMB-PICA; intended for research and forensic applications
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Cayman Chemical Artemitin, Purity: ≥98%, CAS: 479-90-3, 5 mg
A flavonoid with diverse biological activities; scavenges peroxyl radicals in a cell-free assay; inhibits 5-LO (IC50 = 54.6 µM); active against P. falciparum (IC50 = 26 µM); cytotoxic to HL-60 leukemia cells (IC50 = 30.98 µM); decreases mean arterial blood pressure in normotensive rats, as well as reduces angiotensin I-induced, but not angiotensin II-induced, increases in mean arterial blood pressure in rats, at 0.75 mg/kg
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Cayman Chemical GSK1070916, Purity: ≥98%, CAS: 942918-07-2, 10 mg
A potent inhibitor of Aurora B and C (Kis = 0.38 and 1.5 nM, respectively); >250-fold selective for Aurora B and C over Aurora A; inhibits proliferation of A549 lung cancer cells in vitro (EC50 = 7 nM); inhibits proliferation in a panel of 100 tumor cell lines (EC50s = <10 nM); inhibits histone H3 phosphorylation in a COLO 205 mouse xenograft model and induces tumor regression in an HL-60 mouse xenograft model; reduces tumor growth in 10 mouse xenograft models
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Medchemexpress LLC NCP2 Anchor | 1380600-13-4 | C38H36N4O8 | 100 MG
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NCP2 Anchor is used in the synthesis of exon jumping oligomer conjugates. These conjugates complement selected target sites in the human anti-muscular atrophy protein gene, inducing exon 52 jumping. It is suitable for research related to muscular dystrophy.
- Used in the synthesis of exon jumping oligomer conjugates.
- Oligomer conjugates complement target sites in the human anti-muscular atrophy protein gene.
- Induces exon 52 jumping.
- Applicable for research of muscular dystrophy.
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Apexbio Technology LLC SCH772984 HCl 50mg. 56-54-2. MFCD00135581
SCH772984 HCl is a specific inhibitor of extracellular signal-regulated kinase 1/2 (ERK1/2), with IC50 values of 4 nM and 1 nM, respectively. ERK1/2 is a mitogen-activated protein kinase (MAPK) which is involved in the development of various cancers, especially the ones with BRAF or RAS mutations. Phospho-ERK reactivation in cancer cells is associated with resistance to BRAF and MEK inhibitors. Other sizes are available. Please inqury us for quote.
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Selleck Chemical LLC Berbamine S9141-25MG
Berbamine (BA) a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan) is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF- B Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca /calmodulin-dependent protein kinase II (CaMKII)
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Apexbio Technology LLC NEXTURASTAT A 1MG
NEXTURASTAT A 1MG APEXBIO TECHNOLOGIES
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Cayman Chemical HAPC-Chol, Purity: ≥95%, 10 mg
A cationic cholesterol; has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability; has been used to deliver siRNA into mice via intravenous injection, resulting in HAPC-chol accumulation in the lungs
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Cayman Chemical 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-PE, Purity: ≥95%, CAS: 96998-00-4, 5 mg
A phospholipid; found in the nucleus, but not the mitochondria, of mouse liver; levels are lower in pre-term infant plasma compared with maternal and fetal plasma
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Medchemexpress LLC P glycoprotein antibody (YA255) | 10 UL
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P Glycoprotein Antibody (YA255) (PBS only) is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting P Glycoprotein. It is supplied in PBS, pH 7.4. P Glycoprotein is a membrane-associated protein involved in multidrug resistance as an ATP-dependent drug efflux pump for xenobiotic compounds.
- Target specificity for P Glycoprotein.
- Rabbit host with human reactivity.
- Non-conjugated antibody.
- Formulated in PBS, pH 7.4.
- Suitable for Western Blot (WB) at 1:1000-1:50000 dilution.
- Suitable for Immunohistochemistry-Paraffin (IHC-P) at 1:100-1:1200 dilution.
- Store at -20°C for 1 year.
- Avoid repeated freeze/thaw cycles.
- Liquid appearance.
- Shipped with blue ice.
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Cayman Chemical K22, Purity: ≥98%, CAS: 2141978-86-9, 5 mg
An antiviral agent; inhibits replication of SARS-CoV, MERS-CoV, HCoV-229E, FCoV, and MHV in Vero cells at 40 µM; inhibits the formation of double membrane vesicles and viral RNA synthesis in HCoV-229E-infected MRC-5 cells; reduces viral titers in cells infected with various Arteriviridae or Torovirinae viruses
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Medchemexpress LLC N-lactoyl-phenylalanine-13C6 | 183241-73-8 | 98.5% | 243.21 | 5 MG
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N-Lactoyl-Phenylalanine-13C6 is a 13C labeled N-Lactoyl-Phenylalanine. It is a blood-derived signaling metabolite that can be induced by exercise, and can reduce obesity and improve glucose tolerance.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
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Medchemexpress LLC HY-N3519 1mg Medchemexpress, Platycodin D3 CAS:67884-03-1 Purity:>98%
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Medchemexpress, HY-N3519 1mg Platycodin D3 CAS:67884-03-1 Platycodin D3 is a triterpenoid saponin isolated from Platycodon grandiflorum, with anti-HCV activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Stobadine | 85202-17-1 | 99.4% | 202.30 g/mol | C13H18N2 | 1 MG
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Stobadine is a small-molecule antioxidant used in research to prevent free-radical-induced alterations in membrane fluidity and to study oxidative stress-related mechanisms in biochemical and pharmacological assays.
- Antioxidant and free radical scavenger.
- Used in studies of membrane fluidity and cardioprotective mechanisms.
- White to off-white solid suitable for preparing solutions for assays.
- High reported purity for reliable experimental results.
- Recommended storage at low temperatures to preserve stability.
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