Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,206 – 5,220 of 60,541 results

5,206

Cayman Chemical ANTIBODY ML-18 500ug

A BB3 receptor antagonist; inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM); selective for BB3 over GRPR and NMBR (IC50s = 16 and >100 μM, respectively, in a radioligand binding assay); reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells at 16 μM; inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells

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5,207

Cayman Chemical Bivalirudin, Purity: ≥98%, CAS: 128270-60-0, 5 mg

A thrombin inhibitor (Kis = 2.56 and 1.84 nM for α- and ζ-thrombin, respectively); selective for α- and ζ-thrombin, lacking activity at trypsin and γ-thrombin at a >1,000-fold excess; inhibits α-thrombin-stimulated activation of the clotting factors Factor X, Factor V, and prothrombin in contact-activated plasma; reduces platelet deposition in a rat carotid endarterectomy model in a dose-dependent manner

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5,208

Cayman Chemical JWH 250 5-hydroxyindole metabolite, Purity: ≥98%, CAS: 1379604-67-7, 5 mg

Expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine; intended for research and forensic applications

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5,209

Apexbio Technology LLC D609 83373-60-8 5mg

D609 (CAS 83373-60-8) is a selective and competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) with a reported Ki of 6 4 M By inhibiting PC-PLC D609 blocks the hydrolysis of phosphatidylcholine to diacylglycerol and phosphocholine processes implicated in cell signaling and proliferation D609 also inhibits sphingomyelin synthase and exhibits additional antioxidant properties due to its thiol group In cellular studies D609 reduces PC-PLC activity and cell proliferation in OVCAR3 and breast cancer cells and downregulates HER2 expression It also demonstrates anti-inflammatory effects in endothelial cells by suppressing inducible nitric oxide synthase and VCAM-1 gene expression D609 is widely used to investigate lipid-mediated signaling inflammation and cancer biology

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5,210

Medchemexpress LLC N,N-Dimethyl-1-naphthylamine | 86-56-6 | 99.9% | 25 G

N,N-Dimethyl-1-naphthylamine is an aromatic amine and a dye, commonly used in nitrate reduction tests. It appears as a colorless to light yellow liquid.

Molecular weight of 171.24
Chemical formula of C12H13N
Density of 1.060±0.06 g/cm3
Purity of 99.85%

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5,211

Apexbio Technology LLC GSK 2830371 1404456-53-6 10mg

GSK 2830371 (CAS 1404456-53-6) is a potent orally bioavailable small molecule that acts as an allosteric inhibitor of Wip1 phosphatase By selectively targeting Wip1 a serine/threonine phosphatase involved in the regulation of DNA damage response pathways GSK 2830371 disrupts downstream signaling events critical for cell cycle progression and genomic stability The compound exhibits an IC of 6 nM against Wip1 in biochemical assays reflecting high inhibitory potency GSK 2830371 is utilized in biomedical research to investigate Wip1 s role in oncogenic processes and to explore the therapeutic potential of Wip1 inhibition in cancer and related pathologies

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5,212

Cayman Chemical Ceapin-A7, Purity: ≥98%, CAS: 2323027-38-7, 25 mg

An ATF6α inhibitor (IC50 = 0.59 µM in a reporter assay); selective for ATF6α over ATF6β at 18.9 µM; sensitizes U2OS cells to thapsigargin; chondrocyte-conditioned media from primary human chondrocytes pre-incubated with ceapin-A7 (0.5 µM) prior to stimulation with TNF-α, IFN-γ, or IL-17 has a reduced ability to induce tube formation in HUVECs; inhibits viral RNA production in Vero cells infected with SARS-CoV-2 at 15 µM

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5,213

Cayman Chemical JNJ-42847922, Purity: ≥98%, CAS: 1293281-49-8, 50 mg

An orexin receptor 2 antagonist (Ki = 10 nM); selective for OX2R over OX1R (Ki = 794 nM) and a panel of 50 receptors, ion channels, and transporters at 1 µM; reduces the latency to NREM sleep onset and increases the duration of NREM sleep in rats at 3, 10, and 30 mg/kg

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5,214

Medchemexpress LLC Carbamic acid, N-(3-aminopropyl)-, 1,1-dimethylethyl ester | 75178-96-0 | 99.8% | 174.24 | 50 G

tert-Butyl (3-aminopropyl)carbamate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It appears as a colorless to off-white solid below 22°C and a liquid above 22°C. This product is for research use only and should be stored at 4°C, protected from light, and under nitrogen.

Biochemical reagent for life science research
Colorless to off-white appearance
Solid below 22°C, liquid above 22°C
Store at 4°C, protect from light, stored under nitrogen
Purity of 99.82%

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5,215

TARGETMOL CHEMICALS INC PBIT 10MG

Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PBIT inhibits JARID1B histone demethylase (IC50 of about 3 uM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 uM and 4.9 uM respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes . purity: 99%

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5,216

Medchemexpress LLC Yhhu-3792 | 2097826-24-7 | 99.3% | 50 MG

Yhhu-3792 is a small-molecule Notch activator used in neuroscience research to promote neural stem cell self-renewal, increase Hes3 and Hes5 expression, and improve spatial and episodic memory in animal models. It is supplied as a high-purity research reagent with good solubility in DMSO for in vitro studies.

Notch activator with reported neurogenic activity.
Supports neural stem cell self-renewal and upregulation of Hes3 and Hes5.
High purity: 99.34% (analytical grade).
Molecular weight 400.47 g/mol; formula C24H24N4O2.
Soluble in DMSO (≈66.67 mg/mL); ultrasonic assistance may be required.
Store sealed, away from moisture and light; recommended cold storage for solutions.

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5,217

Medchemexpress LLC 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide | 1272353-82-8 | 98.0% | 1 MG

BMS-919373 is a selective, potent IKur (Kv1.5) channel blocker used in cardiovascular research, including studies of atrial electrophysiology. It is provided as a research-grade powder with characterized purity and stability.

Selective IKur (Kv1.5) channel blocker with cardiovascular research applications.
Demonstrated in vitro activity (HEK293 hERG IC50 = 1.9 μM by patch clamp assay).
Chemical formula C25H20N6O2S and molecular weight 468.53 g/mol.
Available in small research pack sizes and stored frozen for long-term stability.
Reported supplier purity approximately 98%, suitable for laboratory research.

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5,218

Medchemexpress LLC NAP-2/CXCL7 Human 10ug

CXCL7 (also known as neutrophil activating peptide 2 NAP-2) is a platelet-derived growth factor that belongs to the ELR CXC chemokine family functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2[1] NAP-2/CXCL7 Protein Human (HEK 293 His) is produced in HEK293 cells with six C-Terminal His-tags It consists of 94 amino acids (S35-D128)

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5,219

Cayman Chemical Fustin, Purity: ≥98%, CAS: 20725-03-5, 5 mg

A flavanone with diverse biological activities; enhances epigallocatechin-3-O-gallate-induced decreases in the viability of U266 cells at 5 and 10 µM; inhibits increases in blood glucose levels, as well as serum total cholesterol, triglyceride, and MDA levels, in a mouse model of streptozotocin-induced diabetes at 50 and 100 mg/kg; prevents Aβ42-induced decreases in contextual- and tone fear conditioning freezing time in mice at 100 mg/kg

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5,220

Medchemexpress LLC Calcium phosphate mo 100g

Calcium phosphate monobasic monohydrate (Calcium superphosphate) is a kind of biological materials or organic compounds that are widely used in life science research[1]

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Bioactive Small Molecules

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Medchemexpress LLC N,N-Dimethyl-1-naphthylamine | 86-56-6 | 99.9% | 25 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Carbamic acid, N-(3-aminopropyl)-, 1,1-dimethylethyl ester | 75178-96-0 | 99.8% | 174.24 | 50 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Yhhu-3792 | 2097826-24-7 | 99.3% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide | 1272353-82-8 | 98.0% | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC NAP-2/CXCL7 Human 10ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Calcium phosphate mo 100g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More