Bioactive Small Molecules
Cayman Chemical IsothIpendylhydrochlorIde 5mg
An antihistamine; protects against MES-induced seizures in rats (ED50 = 57.9 mg/kg)
Cayman Chemical BenzoylhypaconIn 5mg
A monoester diterpene alkaloid with anti-inflammatory activity; inhibits COX-2 activity in a cell-free assay (IC50 = 20.5 µM); reduces histamine-induced vascular permeability in rats at 200 mg/kg
Medchemexpress LLC Transcription Factor EB Antibody (YA3266) | 50 UL
The Transcription Factor EB Antibody (YA3266) is a rabbit-derived antibody designed to react with human proteins. It is supplied as a liquid formulation suitable for various laboratory applications.
- Host: Rabbit
- Reactivity: Human
- Clonality: YA3266
- Molecular weight: Predicted band size 53 kDa; Observed band size 65-70 kDa
- Concentration: 0.3 mg/mL
- Non-conjugated
- Applications include WB, IHC-F, IHC-P, ICC/IF, and IP
- Formulated in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Store at -20°C for 1 year
- Avoid repeated freeze / thaw cycles
- Ships with blue ice
Selleck Chemical LLC Periplocin S9181-5MG
Periplocin (Periplocoside) extracted from the traditional herbal medicine cortex periplocae has cardiac and anticancer activity Periplocin could significantly boost proliferation migration and stimulate collagen production in fibroblast L929 cells which is dependent on activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase and thus promoting wound healing
Selleck Chemical LLC Rhynchophylline S9400-1MG
Rhynchophylline (Mitrinermine) an active component isolated from species of the genus Uncaria acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems such as lightheadedness convulsions numbness and hypertension
Medchemexpress LLC Pilaralisib | 934526-89-3 | 99.14% | 541.02 | 1 ML
Pilaralisib is a potent and highly selective class I PI3Ks inhibitor with IC50s of 39 nM for PI3Kα, 383 nM for PI3Kβ, 23 nM for PI3Kγ, and 36 nM for PI3Kδ. It is also known as XL-147 and SAR245408.
- Potent and highly selective class I PI3Ks inhibitor.
- Inhibits PI3Kα, PI3δ, and PI3Kγ with IC50s of 39, 36, and 23 nM respectively.
- Less potent against PI3Kβ (IC50 of 383 nM).
- ATP-competitive inhibitor with a Ki value of 42 nM for PI3Kα.
- Weak inhibitory activity toward VPS34 (IC50 of approximately 7.0 μM) and DNA-PK (IC50 of 4.75 μM).
- Does not inhibit mTOR activity (IC50 > 15 μM).
- Inhibits EGF-induced PIP3 production in PC-3 and MCF7 cells with IC50s of 220 and 347 nM.
- Causes dose-dependent decrease in phosphorylation of AKT, p70S6K, and S6 in tumors in vivo.
Medchemexpress LLC MAO-B-IN-30 | 82973-15-7 | 98.5% | 344.16 | 5MG
MAO-B-IN-30 (compound IS7) is a potent, selective, and blood-brain barrier-crossing MAO-B inhibitor. It exhibits IC50 values of 19.176 μM for MAO-A and 0.082 μM for MAO-B, indicating its high selectivity for MAO-B. This compound also demonstrates antiproliferative activity while being non-cytotoxic. Furthermore, MAO-B-IN-30 has been shown to reduce levels of TNF-alpha, IL-6, and NF-kB. These characteristics suggest its potential for research into Parkinson's disease.
- It is a potent and selective MAO-B inhibitor.
- It can cross the blood-brain barrier, making it suitable for neurological research.
- It shows antiproliferative activity.
- It is non-cytotoxic, indicating a favorable safety profile in certain contexts.
- It reduces TNF-alpha, IL-6, and NF-kB levels, suggesting anti-inflammatory properties.
- It has potential for Parkinson's disease research.
Cayman Chemical ANTIBODY HIstamIn 25g
A biogenic amine; activates histamine H1-4 receptors to regulate allergic and inflammatory responses, gastric acid secretion, arousal, cognition, and immune cell chemotaxis
Medchemexpress LLC Chst15-IN-1 | 2158198-77-5 | 98.0% | 442.09 | C17H11BrCl2N2O3 | 5MG
Chst15-IN-1 is a potent, reversible covalent inhibitor of the Chst15 sulfotransferase that reduces chondroitin sulfate-E (CS-E) sulfation and inhibits related glycosaminoglycan (GAG) sulfotransferases. It can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs) and has been used in research to promote neuronal repair.
- Potent reversible covalent inhibition of Chst15.
- Reduces CS-E sulfation and inhibits related GAG sulfotransferases.
- Diminishes CSPG-mediated inhibition to support neuronal repair.
- Available as high-purity solid quantities and solution formulations.
- Well characterized for molecular weight and formula for analytical use.
Cayman Chemical ANTIBODY Tegoprazn 10mg
A proton pump inhibitor (IC50 = 0.53 µM in porcine gastric membrane vesicles); inhibits basal gastric acid secretion in pylorus-ligated rats at 10 mg/kg; reduces esophageal mucosal tissue MPO levels in a rat model of reflux esophagitis (ED50 = 5.9 mg/kg); reduces ulcer area in rat models of naproxen-, WIRS-, or ethanol-induced gastric ulcers (ED50s = 0.1, 0.1, and 1.4 mg/kg, respectively)
Medchemexpress LLC AC-263093 (free base) | 849459-86-5 | 99.8% | 319.98 g/mol | C8H8Br2N4 | 10MG
AC-263093 (free base) is a small-molecule research compound reported to activate neuropeptide FF receptor 2 (NPFFR2). Provided as a free base for laboratory use, it is suitable for preclinical receptor pharmacology and biochemical assays. Key identifiers include CAS 849459-86-5, molecular formula C8H8Br2N4, molecular weight 319.98 g/mol, and reported high purity.
- Activates NPFFR2 for receptor pharmacology studies.
- Provided as a free base for formulation flexibility.
- High reported purity supports reproducible results.
- Available in small-scale quantities for preclinical work.
- Batch-level documentation available for verification.
![Medchemexpress LLC 3-(3-chloro-phenoxymethyl)-1-(tetrahydro-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine | 1188296-52-7 | MFCD22123245 | 99.1% | 359.81 g·mol⁻¹ | C17H18ClN5O2 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000236358.png-250.jpg)
Medchemexpress LLC 3-(3-chloro-phenoxymethyl)-1-(tetrahydro-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine | 1188296-52-7 | MFCD22123245 | 99.1% | 359.81 g·mol⁻¹ | C17H18ClN5O2 | 10MG
PF-4800567 is a selective small-molecule inhibitor of casein kinase 1 epsilon (CK1ε) used in research to probe CK1 signaling and circadian rhythm pathways. It potently inhibits CK1ε (IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ and is supplied as research-grade material for biochemical and cell-based assays.
- Potent CK1ε inhibition (IC50 32 nM).
- Greater than 20-fold selectivity over CK1δ (IC50 711 nM).
- Molecular weight 359.81 g·mol⁻¹ and formula C17H18ClN5O2.
- High reported purity (~99.1%).
- Suitable for biochemical and cell-based studies of CK1 signaling and circadian biology.
Cayman Chemical ANTIBODY VItamIn K4 100g
A synthetic form of vitamin K; inhibits proliferation of PC3 cells (IC50 = 20.94 µM); induces cell cycle arrest at the S phase and mitochondrial apoptosis in PC3 cells at 20 and 40 µM; inhibits canonical and non-canonical activation of the NLRP3 inflammasome in mouse BMDMs at 5 µM; decreases the production of IL-1β and peritoneal neutrophil infiltration in a mouse model of monosodium urate-induced NLRP3-dependent peritonitis at 4 mg/kg
