Bioactive Small Molecules
Selleck Chemical LLC Praluzatamab ravtansine-1MG-5
Praluzatamab ravtansine (CX-2009) is a conditionally activated Probody drug conjugate (PDC) comprising an anti-CD166 mAb conjugated to DM4 with a protease-cleavable linker and a peptide mask that limits target engagement in normal tissue and circulation
Cayman Chemical ANTIBODY RamIprIl 5g
A prodrug from of ramiprilat; reduces systolic blood pressure in spontaneously hypertensive rats at 2.5 mg/kg per day; reduces aortic valve backscatter and improves aortic flow in a rabbit model of aortic valve stenosis; decreases paw swelling and serum levels of TNF-α and PGE2, as well as cardiac collagen deposition and fibrosis in a rat model of adjuvant-induced arthritis
Cayman Chemical ANTIBODY ButeIn 10mg
A plant polyphenol that is classified as a chalcone; a potent antioxidant that affects the numerous pathways modulated by oxidant tone, including inflammation, cancer, and immune response
Cayman Chemical ANTIBODY MLS-573151 10mg
A specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM); has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2
Cayman Chemical ANTIBODY LY2874455 5mg
A pan-FGFR inhibitor (IC50s = 2.8, 2.6, 6.4, 6, and 7 nM for FGFR1, FGFR2, FGFR3, FGFR4, and VEGFR2, respectively); inhibits proliferation of KMS-11, OPM-2, SNU-16, and KATO-III cancer cells in vitro and in tumor xenografts in mice
Cayman Chemical ANTIBODY Derquntel 25mg
An anthelmintic spiroindole that acts as a nicotinic acetylcholine receptor antagonist, causing flaccid paralysis and expulsion of nematodes
Medchemexpress LLC Zxh-4-130 TFA | 2711006-67-4 | 99.7% | C48H59F3N6O11S | 10MG
ZXH-4-130 TFA is a hetero-PROTAC trifluoroacetate salt that selectively induces degradation of cereblon (CRBN) by recruiting the VHL E3 ligase. It has demonstrated ~80% CRBN degradation at 10 nM in MM1.S cells and is supplied as a solid research reagent for investigating targeted protein degradation and CRBN-related biology.
- Selective degradation of cereblon (CRBN) at low nanomolar concentrations.
- Hetero-PROTAC mechanism recruiting VHL E3 ligase for targeted ubiquitination.
- Demonstrated cellular activity in MM1.S cells for assay validation.
- High reported purity suitable for research applications.
- Solid form with recommended -20°C sealed storage to preserve stability.
- Intended for use in studies of protein degradation pathways and target validation.
Selleck Chemical LLC Passion Fruit Extract E3044-5MG
Passion Fruit Extract is extracted from Passiflora edulis Sims
Selleck Chemical LLC Malvae Fructus Extract E3164-5MG
Malvae Fructus Extract is extracted from Malvae Fructus which helps to open the veins induce diuresis and disperse swelling dry pus relieve diarrhea quench thirst and is used to treat ischuria and bladder stones
Selleck Chemical LLC Rhubarb Extract E3123-5MG
Rhubarb Extract is obtained from Rheum palmatum L /Rheum officinale of which phytochemicals could promote some bacterial genders involved in gut barrier function therefore be involved in the modulation of the susceptibility to hepatic diseases linked to acute alcohol consumption
Selleck Chemical LLC Semen Canavaliae Extract E3142-5MG
Semen Canavaliae Extract is extracted from Canavalia Gladiate which is a natural antioxidant and antibacterial agent with potential health benefits as well as application in the food industry
Selleck Chemical LLC Tamarixetin E2502-1MG
Tamarixetin (4 -O-Methyl Quercetin) is a natural flavonoid derivative of quercetin and has superior anti-inflammatory properties in bacterial sepsis by increasing the population of IL-10-secreting immune cells
Cayman Chemical Cclesonde 5mg
A prodrug form of desisobutyryl-ciclesonide; binds to the glucocorticoid receptor (Ki = 37 nM); selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors; inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation
Cayman Chemical ANTIBODY CarIporIde 100mg
An NHE-1 inhibitor (IC50 = 0.56 µM in an intracellular pH recovery assay); selective for NHE-1 over NHE-2 (IC50 = 28 µM in an intracellular pH recovery assay); inhibits sodium propionate-induced swelling of isolated human platelets (IC50 = 0.023 µM); reduces the myocardial infarct size as a percentage of the area at risk in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion at 1 mg/kg; decreases ventricular tachycardia duration in a rat model of coronary artery ligation and reperfusion-induced arrhythmia at 1 mg/kg
Medchemexpress LLC Azd-co-ph-peg4-ph-co-azd | 2569143-72-0 | MFCD00231029 | 96.0% | C26H28N2O8 | 10MG
AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker developed for synthesis of antibody-siRNA conjugates. It is supplied as a white to off-white solid (C26H28N2O8; MW 496.51; CAS 2569143-72-0) with reported purity of approximately 96%, and is soluble in DMSO with recommended formulations for in vivo use.
- Bis-β-lactam linker suitable for antibody-siRNA conjugation.
- High reported purity (~96%) supporting experimental reproducibility.
- Solid form simplifies storage and handling.
- Soluble in DMSO (50 mg/mL) for in vitro applications.
- Includes recommended in vivo formulation options for dosing studies.
- Available in small pack sizes appropriate for research use.