Bioactive Small Molecules
Apexbio Technology LLC SU 5402 215543-92-3 10mg
SU 5402 (CAS 215543-92-3) is a selective receptor tyrosine kinase inhibitor targeting VEGFR2 FGFR1 and PDGFR with respective IC50 values of 0 02 M 0 03 M and 0 51 M It exhibits minimal inhibitory activity against EGFR ( 100 M IC50) SU 5402 inhibits FGFR-mediated phosphorylation events impacting downstream signaling pathways including ERK1/2 STAT3 and MAP kinases leading to cell cycle arrest and induction of apoptosis particularly in FGFR3-dependent multiple myeloma cell lines This compound serves as a relevant tool for exploring receptor tyrosine kinase signaling in cancer research
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eMolecules 67655-94-1 | Amastatin | Apollo Scientific | MFCD00038400 | 474.555 | C21H38N4O8 | 0.000 | CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O | 5mg | 562454310
Amastatin | Apollo Scientific | 67655-94-1 | MFCD00038400 | 474.555 | C21H38N4O8 | 0.000 | CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O | 5mg | 562454310
Medchemexpress LLC Hth-01-015 | 1613724-42-7 | 98.8% | 468.55 | C26H28N8O | 10MG
HTH-01-015 is a selective small-molecule inhibitor of NUAK1 (ARK5) with an in vitro IC50 of 100 nM and >100-fold selectivity over NUAK2. Supplied as a solid for research use, it is intended for biochemical and cellular studies probing NUAK1 signaling pathways.
- Selective NUAK1 inhibition with an IC50 of 100 nM.
- Greater than 100-fold selectivity versus NUAK2.
- High reported purity (~98.8%) suitable for research use.
- Available in multiple pack sizes, including milligram quantities.
- Supplied as a solid with recommended cold storage for stability.
- Includes analytical documents (COA, LC-MS, 1H NMR) for quality verification.
Medchemexpress LLC TCS 359 | 301305-73-7 | 99.8% | 360.43 | 1 ML
TCS 359 is a 2-acylaminothiophene-3-carboxamide, functioning as a potent and selective FLT3 inhibitor with an IC50 of 42 nM. It demonstrates inhibition of MV4-11 cell proliferation with an IC50 of 340 nM. This compound is suitable for laboratory research and substance manufacturing.
- Potent and selective FLT3 inhibitor (IC50 of 42 nM)
- Inhibits MV4-11 cell proliferation (IC50 of 340 nM)
- High purity of 99.76%
- Solid appearance, white to yellow in color
- Recommended storage at 4°C, protected from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
Medchemexpress LLC HY-13404 50mg , Capmatinib CAS:1029712-80-8 Purity:>98%
HY-13404 50mg Capmatinib CAS: 1029712-80-8 Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Dibucaine, Purity: ≥98%, CAS: 85-79-0, 5 mg
An anesthetic that acts as a sodium channel blocker
Medchemexpress LLC MS438 10mg | 512840-45-8 | 10 MG
MS438 is a small-molecule thyrotropin receptor (TSHR) agonist with nanomolar potency (EC50 = 53 nM) that binds the serpentine transmembrane portion of TSHR and induces T4 secretion in mice. It is supplied as a white to off-white solid with high purity for research use.
- Potent TSHR agonist with EC50 of 53 nM.
- Binds the serpentine (transmembrane) portion of TSHR.
- Induces T4 secretion in mouse models.
- High purity (99.85%) white to off-white solid.
- Soluble in DMSO at ≥100 mg/mL; compatible with 10% DMSO/90% corn oil for in vivo dosing.
- Recommended storage: powder at -20°C long term; stock solutions at -80°C.
Medchemexpress LLC STING agonist-17 | 2816929-47-0 | 96.2% | C43H53N13O8 | 10 MM * 1 ML
STING agonist-17 is a potent STING agonist with an IC50 value of 0.062 nM, demonstrating anti-cancer activity for tumor immunization.
- Potent STING agonist with an IC50 of 0.062 nM.
- Exhibits anti-cancer activity through tumor immunization.
- Inhibits several CYP isozymes, including CYP3A4 (IC50 = 4.2 μM).
- Induces IFN-β secretion with an EC50 of 2.0 nM in THP-1 dual cells.
- Activates key signaling factors such as STING, TBK1, IRF3, and STAT1.
- Demonstrates an inhibitory effect on tumor growth in in vivo models.
Medchemexpress LLC Leucic acid (α-Hydroxyisocaproic acid) | 498-36-2 | 99.2% | 132.16 | 500 MG
Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of leucine's microbial metabolism. It binds to HCAR2, altering AMPK and ERK1/2 phosphorylation. It suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity, attenuates myotube atrophy. It also suppresses pro-inflammatory cytokine secretion and inflammation-related gene mRNA expression. Useful for obesity research.
- Orally active end-product of leucine metabolism
- Suppresses lipid synthesis, promotes catabolism, reduces adiposity
- Enhances lean mass and exercise capacity
- Suppresses pro-inflammatory cytokine secretion and inflammation
- Decreases basal protein synthesis; attenuates myotube atrophy
- Activates AMPK and p38MAPK signaling
- Useful for obesity research
Medchemexpress LLC Tegafur-Uracil | 74578-38-4 | 99.8% | 312.25 | 25 MG
Tegafur-Uracil (UFT; BMS-200604) is an effective oral chemotherapy drug based on fluoropyrimidine. It inhibits thymidylate synthase and can be used in combination with leucovorin (LV) and polysaccharide K (PSK) for research on solid tumors.
- Inhibits thymidylate synthase.
- Effective oral chemotherapy drug.
- Can be used in combination with leucovorin (LV) and polysaccharide K (PSK) for research on solid tumors.
- Enhances anti-tumor activity in mice when combined with folinic acid and protein-bound polysaccharides.
Medchemexpress LLC Cratoxylone | 149155-01-1 | 5 MG
Cratoxylone is a compound isolated from the bark of Cratoxylum Cochinchinense, known for its antiplasmodial activity. It acts as a parasite inhibitor within the anti-infection pathway, demonstrating inhibition of NO production in LPS-stimulated mouse RAW264.7 cells.
- Possesses antiplasmodial activity
- Inhibits NO production in LPS-stimulated RAW264.7 cells with an IC50 of 5.4 μM
- Appears as a solid, light yellow to yellow substance
- Has a purity of 95.0%
- Molecular formula C24H28O7
- Molecular weight 428.47
- Classified as phenols, polyphenols, and xanthones
- Derived from plants
Medchemexpress LLC Genz-123346 free base | 491833-30-8 | 99.6% | 10 MG
Genz-123346 free base is an orally available inhibitor of glucosylceramide synthase. It blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 of 14 nM. This product is for research use only.
- Potent inhibitor of glucosylceramide synthase and GM1.
- Enhances tumor cell killing by cytotoxic anti-cancer agents through P-gp function modulation.
- Enhancer of autophagy flux.
- In vivo, improves glycemic control, insulin sensitivity, and preserves beta-cell function.
- Normalizes A1C levels and improves glucose tolerance in diet-induced obese mice.
- Blocks polycystic kidney disease by reducing renal GlcCer and GM3 levels.
- Affects Akt-mTOR signaling pathway, reducing Akt and ribosomal protein S6 phosphorylation.
Medchemexpress LLC 3-Fluoro-4-formylphenylboronic acid | 248270-25-9 | 167.93 | 10 G
3-Fluoro-4-formylphenylboronic acid is a biochemical reagent suitable for life science related research. It can be used as a biological material or organic compound. For research use only.
- Powder storage: -20°C for 3 years; 4°C for 2 years
- In solvent storage: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC (DHQD)2PHAL | 140853-10-7 | 778.98 | 10 G
(DHQD)2PHAL is a dimer that can be used as a ligand for the Sharpless asymmetric dihydroxylation reaction. It is a white to off-white solid with a molecular formula of C48H54N6O4.
- Solid appearance
- White to off-white color
- Molecular formula: C48H54N6O4
- Used as a ligand for Sharpless asymmetric dihydroxylation reaction
Medchemexpress LLC HY-103489 1mg Medchemexpress, PI-273 CAS:925069-34-7 Purity:>98%
Medchemexpress, HY-103489 1mg PI-273 CAS:925069-34-7 PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.