Bioactive Small Molecules
Medchemexpress LLC TNG-0746132 | 2821749-57-7 | C26H22F3N7O | 5 MG
TNG-0746132 is a compound that can be used for the synthesis of other compounds with anticancer activity. It is intended for research use only and is not for direct sale to patients.
- High purity (99.48%)
- Soluble in DMSO at 33.33 mg/mL
- Long-term storage stability as powder: 3 years at -20°C, 2 years at 4°C
- Storage stability in solvent: 6 months at -80°C, 1 month at -20°C
Medchemexpress LLC ACVR2B Human/Cynomo 500ug
ACVR2B is a type II member of the TGF- family of receptor Serine/Threonine kinases ACVR2B binds to activins and growth differentiation factors (GDF) which in turn activate type I receptors activating downstream molecule SMAD2/3[1] ACVR2B Protein Human/Cynomolgus (HEK293 hFc) is produced in HEK293 cells with a C-Terminal hFc-tag
Medchemexpress LLC 3-Hydroxylidocaine 10mg | 34604-55-2 | 250.34 | C14H22N2O2 | 10 MG
3-Hydroxylidocaine is an oxidative metabolite of lidocaine provided as a solid research compound. It is used as a reference standard for metabolic, pharmacokinetic, and analytical studies.
- Suitable as an LC-MS/MS reference standard for quantitative analysis.
- Relevant metabolite for in vitro and in vivo lidocaine metabolism studies.
- Supplied as a solid with high purity (≈98.0%).
- Molecular weight 250.34; formula C14H22N2O2.
- Intended for research use only; not for human therapeutic use.
Medchemexpress LLC HY-B0391 500mg Medchemexpress, Naftopidil CAS:57149-07-2 Purity:>98%
Medchemexpress, HY-B0391 500mg Naftopidil CAS:57149-07-2 Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Linderane, Purity: ≥98%, CAS: 13476-25-0, 25 mg
A sesquiterpene; inhibits CYP2C9 (Ki = 1.26 μM); reduces Pck1 and G6pc gene expression, cAMP concentration, and CREB phosphorylation, increases PDE3 activity, and inhibits gluconeogenesis in rat primary hepatocytes; decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice
Medchemexpress LLC Rifamycin S | 13553-79-2 | MFCD06198807 | 98.8% | 695.75 g·mol⁻¹ | C37H45NO12 | 100G
Rifamycin S is an antibiotic compound of the rifamycin family (CAS 13553-79-2) supplied as a solid for research and analytical use. It is an oxidized rifamycin active against Gram-positive bacteria and commonly used as a reference standard and in antibiotic activity assays. Molecular formula C37H45NO12, molecular weight 695.75 g·mol⁻¹.
- High purity (98.8%) suitable for analytical and assay use.
- Characterized chemical data for reproducible results.
- Suitable for microbiology and antibiotic activity studies.
- Multiple pack sizes available to meet small-scale or bulk requirements.
- Safety and handling information provided in the SDS.
Adooq Bioscience LLC ADOOQ BIOSCIENCE LLC Setmelanotide, Selective MC4R Agonist, CAS 920014-72-8
Setmelanotide is a selective melanocortin 4 receptor (MC4R) agonist, effective at EC50s of 0.27 nM for human MC4R and 0.28 nM for rat MC4R. This compound is for research use only.
- Selective melanocortin 4 receptor (MC4R) agonist
- EC50s of 0.27 nM for human MC4R
- EC50s of 0.28 nM for rat MC4R
- Formula: C49H68N18O9S2
- Molecular weight: 1117.31
- CAS number: 920014-72-8
- Store lyophilized at -20°C, keep desiccated
- Lyophilized form stable for 36 months
- In solution, store at -20°C and use within 1 month to prevent loss of potency
- Aliquot to avoid multiple freeze/thaw cycles
- For research use only
Medchemexpress LLC 1-azido-20-bromo-3,6,9,12,15,18-hexaoxaicosane | 2062663-64-1 | 95.0% | C14H28BrN3O6 | 10MG
Bromo-PEG6-azide is a PEG-based bifunctional linker bearing a terminal azide and a bromide. It is intended for use in PROTAC assembly and bioconjugation workflows, enabling click chemistry and nucleophilic substitution while improving solubility through a six-unit PEG spacer.
- Terminal azide enables copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Bromide provides a handle for nucleophilic substitution or alkylation reactions.
- PEG6 spacer increases aqueous solubility and reduces aggregation.
- Flexible spacer length aids in linker design and biological presentation.
- High stated purity suitable for synthetic applications.
- Defined molecular weight simplifies analytical characterization.
Apexbio Technology LLC BTS 1576-37-0 10mM (in 1mL DMSO)
BTS (1576-37-0) is a small-molecule inhibitor targeting skeletal muscle myosin II subfragment 1 (S1) ATPase It is designed to inhibit S1 ATPase activity thereby modulating skeletal muscle contraction by selectively suppressing actin- and Ca2 -stimulated ATP hydrolysis in fast muscle fibers BTS exerts its biological activity primarily through ATPase inhibition In in vitro studies BTS demonstrates selective inhibitory activity with an IC50 value of approximately 5 M against skeletal muscle myosin S1 ATPase Based on these pharmacological properties BTS holds research potential in delineating skeletal muscle contraction-relaxation mechanisms characterizing sarcomere movement and studying metabolic pathways underlying skeletal muscle activity as well as in evaluating pharmacological interventions affecting muscle function
Selleck Chemical LLC Gadodiamide Hydrate 50mg 122795-43-1
Gadodiamide Hydrate, a nonionic Gd3+ chelate, is frequently injected i.v. into magnetic resonance imaging (MRI) to enhance contrast. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC ReACp53 scrambled peptide TFA | 63.7% | 2617.13 | 5 MG
ReACp53 scrambled peptide TFA serves as a negative control for ReACp53 (HY-P0121) and is utilized in the study of ovarian cancer.
- Functions as a negative control for ReACp53
- Molecular formula: C108H206N52O24.XC2HF3O2
- Sequence: Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Ile-Thr-Thr-Arg-Pro-Ile-Leu-Leu-Glu (TFA salt)
- Shortened sequence: RRRRRRRRRRITTRPILLE
- Targets MDM-2/p53
- Pathway involved: Apoptosis
- Peptide content: 63.69%
eMolecules 7390-62-7 | Ambeed | 6-Aminopurine-8(9H)-thione | 250mg | 633657806 | A137922 | MFCD01595977 | 167.19 | C5H5N5S
Ambeed | 6-Aminopurine-8(9H)-thione | 250mg | 633657806 | A137922 | 7390-62-7 | MFCD01595977 | 167.190 | C5H5N5S
Medchemexpress LLC Cbz-D-valine | 1685-33-2 | MFCD00065703 | 99.7% | 251.28 g·mol⁻¹ | C13H17NO4 | 100 G
Cbz-D-valine is the carbobenzyloxy-protected D-enantiomer of valine used as a building block in peptide synthesis and organic chemistry research. It is supplied as a white to off-white solid with high chemical purity for laboratory research applications.
- High purity (99.66%).
- White to off-white solid form.
- Used as a protected amino acid building block for peptide synthesis.
- Provided with defined storage recommendations to preserve stability.
- Intended for research use only, not for human or clinical use.
Medchemexpress LLC Pf-794 | 2056111-45-4 | 99.2% | 25 MG
PF-794 is a potent, selective, ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor (IC50 39 nM) used as a research tool in neuroscience and signal transduction studies. It reduces endogenous p120-catenin phosphorylation in cells and is supplied as a high-purity research chemical.
- Potent TNIK inhibitor with IC50 of 39 nM.
- Selective for the TNIK family.
- Reduces endogenous p120-catenin phosphorylation in cells.
- High reported purity (99.19%).
- Molecular formula C22H20N4O; molecular weight 356.42 g/mol.
Medchemexpress LLC MAT2A inhibitor 2 | 13299-99-5 | 99.7% | 365.85 | 100 MG
MAT2A inhibitor 2 is an orally active inhibitor of methionine adenosine transferase 2A (MAT2A). It has been utilized in osteoporosis studies.
- Specifically inhibits MAT2A.
- Demonstrates oral activity.
- Can be used in osteoporosis research.
- Inhibits ROS levels and activation of NF-κB and MAPK pathways in osteoclasts in vitro.
- Increases protein levels of Nrf2, HO1, and NQO1, and decreases phosphorylation levels of p65, IκBα, p-p38, p-JNK, and p-ERK in BMMs in vitro.
- Inhibits mRNA expression levels of NFATc1, c-FOS, TRAP, CTSK, and MMP9 in BMMs in vitro.
- Prevents bone loss induced by ovariectomy in mice in vivo.
- Attenuates trabecular thickness and osteoclast surface/bone surface ratio in an OVX-induced osteoporosis model.