Bioactive Small Molecules
Medchemexpress LLC Adenosylhomocysteinase (SAHH; AHCY) | 9025-54-1 | ≥140 U/mg protein | 44 kDa | 5 MG
Adenosylhomocysteinase (SAHH; AHCY) is a highly conserved enzyme that reversibly catalyzes S-adenosylhomocysteine (SAH) to adenosine and L-homocysteine. It has a molecular weight of 44 kDa, is stable in the pH range of 6.0-8.0, and is intended for research use only.
- Reversibly catalyzes S-adenosylhomocysteine (SAH) to adenosine and L-homocysteine
- Serum exosomal level acts as a prognostic biomarker in HBV-LC patients
- Obtained by microbial recombination
- Stable in pH range of 6.0-8.0
- Reconstitute with pure water containing 20% glycerol
- Store at 4°C for up to one year after reconstitution
- For extended storage, aliquot and freeze at -20°C; avoid repeated freeze-thaw cycles
Apexbio Technology LLC NPPB 107254-86-4 50mg
NPPB (5-nitro-2-(3-phenylpropylamino)-benzoic acid CAS 107254-86-4) is a small molecule inhibitor of chloride ion channels It acts via interaction sites that include a negatively charged carboxyl group a secondary amine and a nitro substituent contributing partial negative charge facilitating polar interactions with aromatic residues NPPB inhibits chloride currents with reported IC50 values of 80 nM for short-circuit current assays In rat portal vein cells NPPB reduces calcium-activated chloride currents by 58 96% and suppresses up to 90% of norepinephrine- and acetylcholine-induced BK(Ca) potassium currents It also inhibits volume-activated taurine influx (IC50 12 M) NPPB is utilized in studies dissecting chloride and potassium channel function and volume-regulated organic solute transport
Apexbio Technology LLC FAUC-365-5MG
FAUC-365 (CAS No 474432-66-1) is a compound used in biomedical research with a focus on pharmacology and biochemistry Originating from synthetic chemistry FAUC-365 acts primarily by modulating specific cellular pathways targeting receptor interactions that play a role in signal transduction In vitro studies have demonstrated its activity in the nanomolar to low micromolar range making it a potent tool for investigating cellular responses Typical applications involve the use of diverse cell models and animal studies to elucidate its effects often in the context of drug screening and pharmacodynamic evaluations Experimental concentrations typically depend on the specific research design
Cayman Chemical MEGA-9, Purity: ≥95%, CAS: 85261-19-4, 5 g
A nonionic detergent that can be used to solubilize membrane proteins; CMC = 20 mM under no-salt conditions; CMCs = 2-17.1 mM under high and low salt conditions for a variety of salts; has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes
Medchemexpress LLC Cpk20 | 2397708-22-2 | 99.7% | 506.50 | 25 MG
CPK20 is a potent and highly selective KCNT1 channel blocker. It is intended for research use only and not for sale to patients.
- Potent and highly selective KCNT1 channel blocker.
- Can be used in the study of epilepsy.
Medchemexpress LLC BI-4142 | 2682003-36-5 | 96.5% | 521.57 | 100 MG
BI-4142 is a potent, highly selective, and orally active HER2 inhibitor with an IC50 of 5 nM. It demonstrates significant antiproliferative activity against various tumor cells and inhibits HER2-dependent cell lines and downstream signaling. In vivo studies have shown that BI-4142 effectively inhibits tumor growth and oncogenic signaling in xenograft models with good oral bioavailability.
- Potent, highly selective, and orally active HER2 inhibitor.
- Inhibits HER2-dependent cell lines and downstream signaling.
- Demonstrates antiproliferative activity against tumor cells in vitro.
- Effectively inhibits tumor growth and oncogenic signaling in vivo.
- Good oral bioavailability in pharmacokinetic studies.
- Soluble in DMSO for in vitro applications.
Medchemexpress LLC AZD-5672 | 780750-65-4 | 95.7% | 632.78 | 5 MG
AZD-5672 is an orally active, potent, and selective CCR5 antagonist with an IC50 of 0.32 nM. It demonstrates moderate activity against the hERG ion channel (binding IC50=7.3 μM) and is a substrate of human P-gp, inhibiting P-gp-mediated digoxin transport (IC50=32 μM). It can be used for research related to rheumatoid arthritis.
- Potent and selective CCR5 antagonist
- Moderate activity against hERG ion channel
- Inhibits P-gp-mediated digoxin transport
- Useful for rheumatoid arthritis research
Cayman Chemical Acriflavine Mixture, Purity: ≥95% (mixture of flavines), 5 mg
A mixture of proflavine, acriflavine, side-methylated proflavine, and side-methylated acriflavine
Medchemexpress LLC Fmoc-D-Phe(3,4-DiCl)-OH | 177966-58-4 | 98.98% | 456.32 | 5 G
Fmoc-D-Phe(3,4-DiCl)-OH is a phenylalanine derivative. Amino acids and their derivatives are commercially used as ergogenic supplements.
- Can influence the secretion of anabolic hormones.
- Provide fuel during exercise.
- Improve mental performance during stressful tasks.
- Help prevent exercise-induced muscle damage.
- Recognized as beneficial ergogenic dietary substances.
- Intended for research use only.
![Medchemexpress LLC N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-4-[(2-morpholin-4-yl-2-oxoethyl)amino]benzamide | 2073059-82-0 | 98.7% | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231299.png-250.jpg)
Medchemexpress LLC N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-4-[(2-morpholin-4-yl-2-oxoethyl)amino]benzamide | 2073059-82-0 | 98.7% | 1 ML
SBI-993 is a small-molecule analog of SBI-477 that stimulates insulin signaling by deactivating the transcription factor MondoA. It is supplied as solid quantities and as a 10 mM solution in DMSO for research use.
- Stimulates insulin signaling via MondoA deactivation.
- Available as solid quantities (5, 10, 25, 50, 100 mg) and as a 10 mM DMSO solution (1 mL).
- Molecular formula C23H24N4O4S and molecular weight 452.53 g/mol.
- High purity suitable for biochemical assays (98.7%).
- Soluble in DMSO for preparation of concentrated stock solutions.
Medchemexpress LLC HY-111540 10mg Medchemexpress, IDO1-IN-5 CAS:2166616-75-5 Purity:>98%
Medchemexpress, HY-111540 10mg IDO1-IN-5 CAS:2166616-75-5 IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Acumapimod, Purity: ≥98%, CAS: 836683-15-9, 25 mg
An inhibitor of p38α MAPK (IC50 = 50 = 0.3 mg/kg)
Medchemexpress LLC Arg9 TFA (Nona-L-arginine TFA) | 2283335-13-5 | 99.6% | 1423.69 (free acid) | 5 MG
Arg9 TFA (Nona-L-arginine) is a cell-penetrating peptide (CPP) composed of nine arginine residues. This peptide has demonstrated neuroprotective properties, showing significant activity in various models of neuronal damage. It effectively reduces cell death following exposure to excitotoxins and ischemia, making it a potential candidate for research in neurological conditions.
- Functions as a cell-penetrating peptide (CPP).
- Composed of nine arginine residues.
- Exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
- Provides significant neuroprotection in a dose-response manner.
- Reduces infarct volume in a permanent middle cerebral artery stroke model in rats.
Medchemexpress LLC Dibenzo[b,e]oxepin-11(6H)-one | 4504-87-4 | 210.23 | 5 G
Dibenzo[b,e]oxepin-11(6H)-one is a dibenzoxepinone derivative known for its significant antiparasitic activity. It is intended for research use only.
- Exhibits inhibitory effects on the motility of the nematode *Caenorhabditis elegans*
- Treatment with 1 mM can reduce worm thrashing by 80%
- Off-white to light yellow solid appearance
Cayman Chemical CRT0066854, Purity: ≥98%, CAS: 1438881-19-6, 1 mg
A PKCι and PKCζ inhibitor (IC50s = 132 and 639 nM, respectively); an inhibitor of ROCK2 (IC50 = 620 nM); is selective for PKCι, PKCζ, and ROCK2 over typical PKCs and 98 other kinases in a panel at 1 µM; decreases viability of A549 lung carcinoma cells (IC50 = 3.47 µM); decreases colony formation in HeLa cells by 65% at 1 µM; impairs lumen formation in MDCK cells in a Matrigel™ assay and migration of NRK-49F cells in a wound assay