Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,061 – 6,075 of 60,541 results

6,061

Cayman Chemical Tubermycin B, Purity: ≥98%, CAS: 2538-68-3, 5 mg

A bacterial metabolite; active against A. flavus, C. albicans, F. oxysporum, R. solani, and T. rubrum (MICs = 64, 8, 125, 32, and 4 µg/ml, respectively); prevents the development of foliar anthracnose lesions in C. orbiculare-infected cucumber plants

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6,062

Cayman Chemical PD 404182, Purity: ≥98%, CAS: 72596-74-8, 10 mg

An antiviral agent; inhibits SARS-CoV-2 Mpro activity (IC50 = 0.081 µM); prevents HSV-1 and HSV-2 infection in Vero cells at 0.2 µM; inhibits DDAH-1 and HDAC8 (IC50s = 9 and 0.011 µM for the human enzymes, respectively); inhibits bacterial KDO 8-P synthase (Ki = 0.026 µM); reduces endothelial tube formation and LPS-induced NO production in primary human dermal microvascular endothelial cells

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6,063

Medchemexpress LLC 3'-Sialyllactose (sodium) | 128596-80-5 | MFCD00166999 | 99.9% | 655.53 | C23H38NNaO19 | 50 MG

3'-Sialyllactose (sodium) is the sodium salt of a milk-derived oligosaccharide supplied for research use. It is reported to act as a prebiotic and to modulate immune responses, with documented anti-inflammatory and anti-arthritic effects. The material is provided as a high-purity solid for biochemical, microbiome, and inflammation-related studies.

High purity (99.9%) suitable for research
Provided as a stable sodium salt solid for handling and storage
Useful for prebiotic and microbiome studies
Supports research into immune homeostasis and anti-inflammatory effects
Well-characterized chemical identity and molecular weight (655.53)

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6,064

Medchemexpress LLC Almorexant hydrochloride | 913358-93-7 | MFCD22419385 | 100.0% | 549.02 | C29H32ClF3N2O3 | 10 MG

Almorexant hydrochloride is an orally active, competitive dual orexin (OX1/OX2) receptor antagonist for research use. Provided as the hydrochloride salt, it is supplied in solid and solution formats with accompanying datasheet and safety documentation for laboratory studies of orexin signaling and sleep-wake regulation.

Orally active dual orexin receptor antagonist.
High reported purity for research applications.
Available as solid and as 10 mM solution in DMSO.
White to off-white solid appearance.
Includes datasheet and safety data sheet documentation.
Molecular weight 549.02 g/mol.

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6,065

Dojindo Molecular Technologies Inc ECGreen-Endocytosis Detection (40 ul)

Endocytosis contributes to the maintenance of intracellular homeostasis by bringing in various nutrients to the cell and transporting unwanted components to the lysosome, acting as a waste disposal system. Fluorescent dextran conjugates, internalized via endocytosis, are widely used for monitoring the endocytic pathway in living cells. However, dextran size affects both internalization and dynamics inside the endocytic pathway, suggesting that care must be taken when using dextran conjugates. ECGreen is a small molecule fluorescent probe that is not membrane permeable. ECGreen is internalized via endocytosis and its fluorescence intensity is enhanced as the acidity increases. Unlike conventional dextran conjugates, ECGreen allows direct observation of the membrane of an internalized vesicle, making it suitable for live-cell imaging of endocytosis. Dojindo offers various reagents for cell membrane research. (https://www.dojindo.com/track-the-dynamics-of-plasma-membrane/)

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6,066

Cayman Chemical N,N',N''-Triacetylchitotriose, Purity: ≥95%, CAS: 38864-21-0, 5 mg

A triose oligosaccharide derived from chitin; scavenges reactive oxygen species and protects DNA from oxidative damage

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6,067

Cayman Chemical BPTES, Purity: ≥95%, CAS: 314045-39-1, 10 mg

An allosteric inhibitor of GLS1 (IC50 = 3.3 μM); selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase; decreases glutaminase activity and reduces proliferation of aerobic P493 cells; induces cell death, increases the production of ROS, and reduces ATP levels in hypoxic P493 cells; decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with UK 5099 and/or etomoxir; reduces tumor volume in a P493 lymphoma mouse xenograft model at 12.5 mg/kg

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6,068

Cayman Chemical AL 082D06, Purity: ≥98%, CAS: 256925-03-8, 1 mg

A non-steroidal glucocorticoid receptor antagonist; selective for GR over the androgen, progesterone, mineralocorticoid, and estrogen receptors (Kis = >4, >3, >3, and >10 µM, respectively; inhibits glucocorticoid-induced transcription and reverses dexamethasone-mediated repression of gene expression; inhibits DNA binding in vitro and in vivo; GR bound to AL 082D06 does not compete with a constitutively active GR

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6,069

Cayman Chemical AMG 337, Purity: ≥98%, CAS: 1173699-31-4, 1 mg

A selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, which subsequently blocks downstream PI3K and MAPK pathways; inhibits cell proliferation in various c-Met-dependent tumor models

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6,070

Cayman Chemical CU-76, Purity: ≥95%, CAS: 2400954-58-5, 10 mg

A cGAS inhibitor (IC50 = 0.24 µM); reduces DNA-induced dimerization of IRF3 in THP-1 cells; decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells at 10, 30, and 100 µM

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6,071

U.S. Pharmacopeia SIROLIMUS (50 MG)

CAS 53123-88-9

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6,072

Cayman Chemical STM2457, Purity: ≥98%, CAS: 2499663-01-1, 25 mg

An inhibitor of the METTL3/14 complex (IC50 = 16.9 µM); inhibits growth in a panel of AML cell lines (IC50s = 0.6-10.3 µM); inhibits the proliferation, migration, and invasion of HuCC-T1 and HCCC-9810 ICC cells; increases survival in a PDX mouse model of AML at 50 mg/kg

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6,073

Cayman Chemical NCB-0846, Purity: ≥90%, CAS: 1792999-26-8, 5 mg

A TNIK inhibitor (IC50 = 21 nM); selective for TNIK over a panel of 46 kinases but does inhibit FLT3, JAK3, PDGFRα, TrkA, Cdk2/CycA2, and HGK by >80% at 100 nM; inhibits phosphorylation of TCF4 and autophosphorylation of TNIK in cell-based assays at 3 µM; inhibits the growth and colony formation of HCT116 cells in two-dimensional growth and soft-agar assays, respectively, as well as reduces tumor growth in an HCT116 mouse xenograft model; reduces tumor growth in PDX mouse models of colon cancer at 50 and 100 mg/kg

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6,074

Cayman Chemical BAY-3827, Purity: ≥98%, CAS: 2377576-35-5, 5 mg

An AMPK inhibitor (IC50 = 1.4 nM at 10 µM ATP); selective for AMPK over Aurora A kinase, FLT3, and c-Met (IC50s = 1,324, 124, and 788 nM, respectively), RSK2, RSK3, RSK4, MSK1, and MST3 (IC50s = 52, 36, 24, 43, and 94 nM, respectively), and a panel of 331 kinases at 10 µM but does inhibit RSK1 (IC50 = 9 nM); selectively inhibits the proliferation of androgen-dependent LNCaP, VCaP, and 22Rv1 prostate cancer cells (IC50s = 0.28, 1.71, and 5.55 µM, respectively) over androgen receptor-negative C4-2B, PC3, and DU145 prostate cancer cells (IC50s = >10 µM for all)

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6,075

Cayman Chemical CJC-1295 (acetate), Purity: ≥95%, 5 mg

A synthetic peptide derivative of GHRH; does not contain a DAC moiety, which reduces its half-life; increases the secretion of growth hormone in primary rat anterior pituitary cells when used from pM to µM concentrations; increases the secretion of growth hormone into rat blood at 1 µmol/kg, s.c.

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Bioactive Small Molecules

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Medchemexpress LLC 3'-Sialyllactose (sodium) | 128596-80-5 | MFCD00166999 | 99.9% | 655.53 | C23H38NNaO19 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Almorexant hydrochloride | 913358-93-7 | MFCD22419385 | 100.0% | 549.02 | C29H32ClF3N2O3 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 3'-Sialyllactose (sodium) | 128596-80-5 | MFCD00166999 | 99.9% | 655.53 | C23H38NNaO19 | 50 MG

Medchemexpress LLC Almorexant hydrochloride | 913358-93-7 | MFCD22419385 | 100.0% | 549.02 | C29H32ClF3N2O3 | 10 MG