Bioactive Small Molecules
Apexbio Technology LLC GNE-7915 1351761-44-8 10mM (in 1mL DMSO)
GNE-7915 (CAS 1351761-44-8) is a potent selective and brain-penetrant inhibitor of leucine-rich repeat kinase 2 (LRRK2) exhibiting Ki and IC50 values of approximately 1 nM and 9 nM respectively Despite broad kinase screening GNE-7915 demonstrates high selectivity substantially interacting with only a limited set of kinases at 100 nM It notably induces LRRK2 dephosphorylation in brain tissue of transgenic mice and reduces TNF and CXCL10 expression at elevated concentrations ( 3 M) This compound serves as a valuable molecular tool for neurodegenerative disease research involving LRRK2 signaling
Medchemexpress LLC Usp7-in-8 | 2009273-60-1 | 99.0% | C21H21N3O2 | 10MG
USP7-IN-8 is a selective small-molecule inhibitor of ubiquitin-specific protease 7 (USP7) used in biochemical and cellular research to probe deubiquitination pathways and investigate effects on protein stability, DNA repair, and cancer-related processes. It is supplied as a high-purity solid and is suitable for use in compound screening, biochemical assays, and cellular studies when handled under appropriate laboratory conditions.
- Selective inhibition of USP7 with reported biochemical potency.
- High chemical purity suitable for research applications.
- Available in multiple solid and solution formats for experimental flexibility.
- Stable under recommended storage conditions for extended shelf life.
- Applicable to studies of protein ubiquitination, DNA repair, and cancer biology.
Medchemexpress LLC Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly | 104914-40-1 | 99.4% | 1377.66 | 5 MG
Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly is a 13-mer synthetic peptide containing seven amino acids homologous to SV40 T antigen. It is capable of inducing nuclear transport.
- Molecular weight: 1377.66
- Formula: C60H104N20O15S
- CAS No.: 104914-40-1
- Appearance: Solid
- Color: White to off-white
- Sequence: Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly
- Sequence shortening: CGYGPKKKRKVGG
- Purity: 99.43%
- For research use only
- Capable of inducing nuclear transport
Medchemexpress LLC Taltobulin intermediate-3 | 610786-69-1 | 99.7% | 235.75 | 100 MG
Taltobulin intermediate-3 is an intermediate in the synthesis of Taltobulin. Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor.
- Disrupts tubulin polymerization
- Induces mitotic arrest
- Induces apoptosis
Cayman Chemical 4-Methyl-7-(4-nitro-2-(trifluoromethyl)phenoxy)-2H-chromen-2-one, Purity: ≥98%, CAS: 433254-36-5, 5 mg
A turn-on fluorescent probe for H2S; excited at 348 nm in DMSO and fluorescence intensity increases in the presence of HS-; selective for HS- over cysteine, AcO-, F-, H2PO4-, Cl-, Br-, and I- and is not cytotoxic up to a concentration of 150 µg/ml
Medchemexpress LLC Ontunisertib (AGMB-129) | 2647949-48-0 | 99.95% | 469.49 | 5 MG
Ontunisertib (AGMB-129) is an orally active and selective gastrointestinal-restricted ALK5 (TGFβR1) inhibitor. It blocks signaling of the pro-fibrotic TGFβ pathway and can be used for the research of fibrostenotic Crohn's disease.
- Orally active and selective gastrointestinal-restricted ALK5 (TGFβR1) inhibitor.
- Blocks signaling of the pro-fibrotic TGFβ pathway.
- Can be used for the research of fibrostenotic Crohn's disease.
- Designed to act locally in the gastrointestinal tract, enabling high exposure in the target tissue.
- Rapidly inactivated in the liver following absorption to avoid potential toxicities associated with systemic TGFβ signaling inhibition.
Cayman Chemical AZD 0095, Purity: ≥98%, CAS: 2750001-23-9, 50 mg
An MCT4 inhibitor (IC50 = 1.3 nM); selectively inhibits lactate influx in NCI H358 cells (IC50 = 6.1 nM), which highly express MCT4 and do not express MCT1, over lactate influx in K562 cells (IC50 = >30 µM), which highly express MCT1 and do not express MCT4; inhibits the proliferation of NCI H358 cells (IC50 = 26 nM); reduces tumor growth in an NCI H358 mouse xenograft model at 100 mg/kg twice per day in combination with cediranib
Medchemexpress LLC KRAS G12D inhibitor 5mg | 2757095-12-6 | 748.11 g/mol | C36H32ClF6N5O4 | 5 MG
KRAS G12D inhibitor 3 TFA is a small-molecule trifluoroacetate salt developed for preclinical research targeting the KRAS G12D mutation. Supplied in milligram quantities, the compound is characterized by analytical data to support experimental use.
- High purity suitable for research use
- Provided as a trifluoroacetate (TFA) salt
- Analytical characterization available: COA, NMR, HPLC, LCMS
- Intended for preclinical cancer and cellular studies
- Offered in low-milligram quantities for assay development
Cayman Chemical CGK733, Purity: ≥98%, CAS: 905973-89-9, 25 mg
An anticancer compound; originally identified as an ATM and ATR kinase inhibitor in a study that has since been retracted; inhibits irradiation-induced ATM kinase activation in HEK293 cells at 10 µM but does not inhibit irradiation-induced phosphorylation of ATM or Chk2 in H460 or UV radiation-induced Chk1 phosphorylation at the same concentration; inhibits ATM kinase activity in a D54 glioblastoma mouse xenograft model at 25 mg/kg; reduces tumor growth in a CNE-2 nasopharyngeal carcinoma mouse xenograft model
Cayman Chemical Quinine, Purity: ≥95%, CAS: 130-95-0, 10 g
An antimalarial agent (MICs = 10-500 nM for P. falciparum); inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme; reduces mouse P. berghei parasite load in the blood with an MED of 150 mg/kg
Medchemexpress LLC HY-107831 100mg Medchemexpress, 5-Acetylsalicylic acid CAS:13110-96-8 Purity:>98%
Medchemexpress, HY-107831 100mg 5-Acetylsalicylic acid CAS:13110-96-8 5-Acetylsalicylic acid has anti-inflammatory and is considered to be the active agent in inflammatory bowel disease (IBD) [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 5-bromo-3-iodo-4-azaindole | 1190319-16-4 | 99.4% | 322.93 g/mol | C7H4BrIN2 | 1 G
5-Bromo-3-iodo-4-azaindole is an organic intermediate used in medicinal chemistry as a building block for the synthesis of biologically active compounds. It is supplied as a solid reagent for laboratory research use.
- Molecular formula: C7H4BrIN2.
- Molecular weight: 322.93 g/mol.
- Cas number: 1190319-16-4.
- Purity: 99.4%.
- Form: solid.
- Storage: powder at 4°C, protect from light; in solvent -80°C (6 months) or -20°C (1 month), protect from light.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Fmoc-D-Ala-OH | 79990-15-1 | MFCD00062960 | 311.33 | 500 G
Fmoc-D-Ala-OH is an alanine derivative intended for research use only. This compound is not for patient use and is recognized as a beneficial ergogenic dietary substance due to its influence on anabolic hormones and exercise-related performance.
- Alanine derivative for research purposes
- Affects secretion of anabolic hormones
- Provides fuel during exercise
- Enhances mental performance under stress
- Helps prevent exercise-induced muscle damage
- Molecular Formula: C18H17NO4
- Appearance: White to off-white solid
![Medchemexpress LLC N-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)demethyltamoxifen | 1481401-71-1 | 99.8% | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000234512.png-250.jpg)
Medchemexpress LLC N-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)demethyltamoxifen | 1481401-71-1 | 99.8% | 1 ML
Fluorescent tamoxifen derivative used to label intracellular tamoxifen-binding sites (estrogen receptors). Supplied as a 10 mM solution in DMSO (1 mL) or as a solid; suitable for cell imaging and receptor localization studies.
- labels intracellular tamoxifen-binding sites
- retains antiestrogenic activity in breast cancer cells
- devoid of estrogenic agonist effect on the uterus
- available as a 10 mM solution in DMSO or as a solid
- high purity suitable for biochemical and imaging assays
Medchemexpress LLC 3,5-pyridinedicarboxylic acid dimethyl ester derivative | 186185-03-5 | 99.9% | 25 MG
BMS-193885 is a selective neuropeptide Y1 (NPY Y1) receptor antagonist supplied as a 25 mg research-grade sample with high purity for use in biochemical and pharmacological studies.
- High purity (99.9%).
- Molecular formula C33H42N4O6.
- Molecular weight 590.71 g/mol.
- Provided as a 25 mg sample (solid).
- Suitable for in vitro and in vivo studies of appetite regulation and NPY signaling.