Bioactive Small Molecules
Medchemexpress LLC LEM-14 | 100MG
LEM-14 is a potent and selective NSD2 inhibitor with an IC50 of 132 M LEM-14 has very weak activitvagainst NSD1 and has no activity against NSD3 LEM-14 inhibits fibrotic gene expression in ND but not DIO BMDMs LEM-14 combined with ionizing radiation (IR) enhances the apoptosis rate and reduces the colony-formation ability of CRC cells LEM-14 exhibits enhanced anti-tumor efficacy in Balb/c nude mice bearing LoVo cell xenografts when combined with ionizing radiation LEM-14 has the potential for the research of multiple myeloma and colorectal cancer[1][2][3]
Cayman Chemical SNS-314 (mesylate), Purity: ≥98%, CAS: 1146618-41-8, 10 mg
A pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively); inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM); inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma cells in vitro (EC50 = <16 nM) and in a mouse xenograft model at a dose of 50 mg/kg; inhibits tumor growth in A2780 ovarian, A375 melanoma, H1299 lung, MDA-MB-231 breast, and PC3 prostate cancer mouse xenograft models
Cayman Chemical DADLE, Purity: ≥98%, CAS: 63631-40-3, 50 mg
A peptide agonist of δ-opioid receptors (Ki = 2.06 nM in a radioligand binding assay); selective for δ-opioid over κ-opioid receptors (Ki = 16,000 nM) but also agonizes of μ-opioid receptors (Ki = 13.8 nM); inhibits electrically induced contractions in guinea pig myenteric plexus and mouse and rat vas deferens (IC50s = 8.9, 0.73, and 134 nM, respectively); induces analgesia in the tail-flick and hot plate tests in mice (ED50s = 0.03 and 0.027 nmol per animal, i.c.v.)
Medchemexpress LLC DD-03-171 | 2366132-45-6 | 98.7% | 5 MG
A PROTAC small-molecule degrader of Bruton's tyrosine kinase (BTK) intended for research use; degrades BTK, IKZF1, and IKZF3, and inhibits mantle cell lymphoma cell proliferation in reported assays.
- Degrades BTK, IKZF1, and IKZF3.
- Reported IC50 approximately 5.1 nM for inhibition of MCL cell proliferation.
- Available as solid (5 mg-500 mg) and as 10 mM solution in DMSO.
- High purity (98.7%).
- For research use only; not for human or clinical use.
Cayman Chemical VcMMAE, Purity: ≥98%, CAS: 646502-53-6, 1 mg
A drug-linker molecule; has been used in the synthesis of ADCs
Cayman Chemical MSX-122, Purity: ≥98%, CAS: 897657-95-3, 5 mg
A partial antagonist of CXCR4; reduces inflammation in a mouse model of experimental colitis; prevents the production of TNF-α, IL-1β, and IL-6; reduces TNF-α secretion by macrophages infected with patient-derived invasive E. coli; decreases metastases in three different mouse models
Medchemexpress LLC N-(2-(2-hydroxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)acetamide | 149457-04-5 | 1g
Ellamod impurity 11is an impurity of Ellamod
Medchemexpress LLC PI3K/mTOR inhibitor-13 sodium | 2361009-23-4 | 98.1% | 464.40 g/mol | C20H13F2N5NaO3S | 10 MG
PI3K/mTOR inhibitor-13 sodium is an orally active small-molecule dual inhibitor of phosphoinositide 3-kinase (PI3K) and mTOR kinases provided as the sodium salt for preclinical research applications. It is used to probe PI3K/mTOR signaling in oncology and fibrotic disease models and is supplied in small research quantities with documented purity and supporting documentation.
- Oral dual PI3K and mTOR kinase inhibitor.
- High reported purity (98.13%).
- Available in small research quantities, including a 10 mg vial.
- Suitable for in vitro and in vivo preclinical studies.
- Includes supporting documentation such as COA and SDS.
Medchemexpress LLC Sauchinone | 177931-17-8 | MFCD08702698 | 356.37 | 20 MG
Sauchinone is a natural product isolated from *Saururus chinensis*. It is a solid compound used as a laboratory chemical and for the manufacture of substances, including applications in pharmaceutical, nutraceutical, and cosmetic research.
- Solid appearance
- Melting/freezing point of 224-226°C
- Relative density of 1.43 g/cm³
- Stable under recommended storage conditions
- Suitable for various research applications
Medchemexpress LLC EM-163 | 1206480-93-4 | 95.0% | 849.88 | 1 MG
EM-163 is a summative BB-Loop analog that can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. It can be utilized in the study of SEB poisoning (Staphylococcal enterotoxin B).
- Alleviates inflammation.
- Prevents death from toxic shock by targeting the TIR domain of MyD88.
- Can be used in the study of SEB poisoning.
- Inhibits the interaction of the TIR-TIR domain.
- Inhibits the production of TNF-α, IFN-γ, IL-2 and IL-1b induced by SEB in human mononuclear cells.
- Effectively inhibits the release of proinflammatory cytokines and delays or avoids death from toxic shock caused by SEB in BALB/c mice.
Cayman Chemical MTIC, Purity: ≥98%, CAS: 3413-72-7, 25 mg
A DNA alkylating agent; active metabolite of dacarbazine (DTIC); active degradation product of temozolomide; cytotoxic to L-cells and decreases thymidine and uridine uptake by 55 and 65%, respectively, at 1 mM; cytotoxic to TLX5 murine lymphoma cells; induces formation of mammary adenofibromas in rats when administered at a cumulative dose of 890 mg per animal over 14 weeks
Medchemexpress LLC 4'-Fluorouridine | 1613589-24-4 | MFCD33551704 | 99.9% | 262.19 | C9H11FN2O6 | 5 MG
EIDD-2749 (4'-Fluorouridine) is a ribonucleoside analog and orally active RNA-dependent RNA polymerase (RdRp) inhibitor used for antiviral research. It has demonstrated activity against respiratory syncytial virus, SARS-CoV-2, hepatitis C virus, and lymphocytic choriomeningitis virus, and is supplied at research-grade purity for laboratory studies.
- Orally active RdRp inhibitor.
- Demonstrated antiviral activity against multiple RNA viruses.
- High purity suitable for research applications.
- Available in small milligram pack sizes for dose-ranging studies.
- Stable when stored under recommended conditions.
Selleck Chemical LLC MP-513 hydrobromide hydrate E4814-25MG
Teneligliptin Hydrobromide Hydrate(MP-513 hydrobromide hydrate) is a potent competitive and long-lasting inhibitor of DPP-4 It competitively inhibited rhDPP-4 human plasma and rat plasma with IC50 values of 0 889 1 75 and 1 35 nM respectively It suppresses high glucose-mediated mitochondrial dysfunction and can be used for treatment of type 2 diabetes
Medchemexpress LLC Piperazine, 1-(diphenylmethyl)-4-methyl- | 82-92-8 | 98.6% | 25 MG
Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. It can be used for the research of nausea, vomiting, and dizziness.
- Potent and selective histamine H1 receptor antagonist.
- Can be used for the research of nausea, vomiting, and dizziness.
- For research use only.
- Solid, white to off-white appearance.
Medchemexpress LLC DPQ 10mM 1mL | 129075-73-6 | 302.41 g/mol | C18H26N2O2 | 1 ML
DPQ is a selective PARP-1 inhibitor supplied as a ready-to-use 10 mM solution in DMSO for research use. It blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, and is used in biochemical and cell-based assays to study PARP-related pathways.
- Ready-to-use 10 mM solution in DMSO.
- Pack size 1 mL.
- High purity (99.68%).
- Molecular weight 302.41 g/mol.
- Suitable for biochemical and cell-based assays investigating DNA repair and inflammatory signaling.