Isotopically Labeled Compounds
Medchemexpress LLC Glyphosate-13C2,15N | 1185107-63-4 | 99.9% | 5 MG
Glyphosate-13C2,15N is the 13C and 15N labeled Glyphosate (HY-B0863). Glyphosate is an herbicidal derivative of the amino acid glycine. It targets and blocks the shikimate pathway in plants, a metabolic pathway not found in animals, which is essential for the synthesis of aromatic amino acids in plants.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Molecular weight: 172.05
- Formula: C13C2H815NO5P
- Appearance: Solid
- Color: White to off-white
- Solubility: 13.89 mg/mL in H2O (80.73 mM; requires ultrasonic and warming)
Medchemexpress LLC Dinotefuran-d3 | 2934813-27-9 | 98.71% | 1 MG
Dinotefuran-d3 is a deuterium-labeled variant of Dinotefuran, an insecticide belonging to the neonicotinoid class. Its primary mode of action is to disrupt the insect's nervous system by inhibiting nicotinic acetylcholine receptors. This product is exclusively for research purposes and is not for sale to patients.
- Serves as a tracer for quantitation during drug development.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium substitution may influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Diethyltoluamide-d7 | 1219799-37-7 | 98.5% | 1 MG
Diethyltoluamide-d7 is the deuterium labeled Diethyltoluamide. It is the most common active ingredient in insect repellents, providing protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects. This product is for research use only.
- Deuterium labeled
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Sotalol-d6 hydrochloride | 1246820-85-8 | 99.0% | 1 MG
Sotalol-d6 hydrochloride is a deuterium labeled Sotalol hydrochloride. It acts as an orally active, non-selective competitive β-adrenergic receptor blocker and a potent antiarrhythmic agent, primarily used in the research of pediatric arrhythmias. The compound functions by blocking β-receptors and potassium KCNH2 channels.
- Deuterium labeled compound
- Non-selective competitive β-adrenergic receptor blocker
- Potent antiarrhythmic agent
- Blocks β-receptors and potassium KCNH2 channels
- Useful as a tracer in quantitative analysis
- Serves as an internal standard for NMR, GC-MS, or LC-MS analysis
- Solid appearance
- White to off-white color
Medchemexpress LLC NBD Sphingosine | 1449370-25-5 | ≥99.0% | 50 UG
NBD Sphingosine (NBD-Sph) is a fluorochrome, a fluorescence-labeled sphingosine. It can be used for fluorescence assays for sphingosine kinases.
- Used for fluorescence assays for sphingosine kinases
- Fluorochrome
- Fluorescence-labeled sphingosine
Medchemexpress LLC Fingolimod-d4 | 1346747-38-3 | MFCD19704989 | 99.1% | 311.50 | 100 MG
Fingolimod-d4 is the deuterium labeled Fingolimod. It is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist and also functions as a pak1 activator and an immunosuppressant. Deuterium labeling allows its use as a tracer for quantitation during drug development and has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled
- Brain-penetrant sphingosine 1-phosphate (S1P) antagonist
- Pak1 activator
- Immunosuppressant
- Can be used as tracers for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Ranolazine-d3 | 1054624-77-9 | 99.5% | 100 MG
Ranolazine-d3 is a deuterium labeled anti-angina agent that inhibits the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure. It also functions as a partial fatty acid oxidation inhibitor and is intended for research use only.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC D-Glucose-d4 | 478529-49-6 | 99.0% | 50 MG
D-Glucose-d4 is the deuterium-labeled form of D-Glucose, an important monosaccharide and carbohydrate in biology. It serves as a critical signaling molecule and component of general metabolism. This compound can be utilized as a tracer and as an internal standard for quantitative analysis methods like NMR, GC-MS, or LC-MS.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Cefoperazone-d5 | 2410425-70-4 | 98.6% | 100 UG
Cefoperazone-d5 is deuterium labeled Cefoperazone. Cefoperazone, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantitation during drug development.
- Deuteration is noted for its potential to impact the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Pimobendan-d3 | 74150-27-9 | 99.4% | 50 MG
Pimobendan-d3 (UD-CG115-d3) is deuterium labeled Pimobendan. It is a selective inhibitor of PDE3 with an IC50 of 0.32 μM. Deuterium labeled compounds are used as tracers for quantitation during drug development due to their potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- For research use only
Medchemexpress LLC Norgestrel-d6 | 2376035-98-0 | 99.5% | 5 MG
Norgestrel-d6 is the deuterium labeled Levonorgestrel, a synthetic progestogen used as an active ingredient in some hormonal contraceptives. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It is intended for research use only and can serve as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled Levonorgestrel
- Synthetic progestogen
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- For use as a tracer or internal standard
- Suitable for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Naratriptan-d3 hydrochloride | 1190021-64-7 | 1 MG
Naratriptan-d3 is a deuterium labeled form of Naratriptan hydrochloride, a selective 5-HT1B/1D receptor agonist. This compound is peripherally active and exhibits good oral bioavailability, inducing cranial artery vasoconstriction. It also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation, making it suitable for research into acute migraine, targeting cranial vascular and neuroinflammatory mechanisms.
- Used as a tracer
- Internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Acts as a selective 5-HT1B/1D receptor agonist
- Exhibits good oral bioavailability
- Induces cranial artery vasoconstriction
- Inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation
- Reduces sterile inflammation
Medchemexpress LLC Pantothenic acid-13C3,15N hemicalcium | 356786-94-2 | 99.3% | 5 MG
Pantothenic acid-13C3,15N (hemicalcium) is the 13C-labeled and 15N-labeled D-Pantothenic acid. D-Pantothenic acid is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC D-Glucose-13C-5 | 106032-62-6 | >98.0% | 50 MG
D-Glucose-13C-5 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is a significant carbohydrate in biology. It serves as a carbohydrate sweetener and a critical component of general metabolism, also functioning as a crucial signaling molecule related to both cellular metabolic status and biotic and abiotic stress responses. Stable heavy isotopes, such as carbon-13, are incorporated into drug molecules for use as tracers in quantitative analysis during drug development.
- Labeled with 13C isotope
- Monosaccharide, significant carbohydrate in biology
- Functions as a crucial signaling molecule
- Used as a tracer in quantitative analysis
- Molecular formula C5¹³CH12O6
- Molecular weight 181.15
- Target: Endogenous Metabolite; Isotope-Labeled Compounds
- Pathway: Metabolic Enzyme/Protease; Others
- In Vitro Solubility: H2O: 30 mg/mL (165.61 mM; Need ultrasonic)
Medchemexpress LLC Piribedil-d8 | 1398044-45-5 | 99.8% | 1 MG
Piribedil-d8 is a deuterium-labeled analog of Piribedil, an antiparkinsonian agent known for its activity as a dopamine D2 and D3 agonist and α2-adrenoceptors antagonist. This compound serves as a valuable tracer and internal standard for quantitative analysis in various analytical techniques, including NMR, GC-MS, and LC-MS.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis
- Acts as a dopamine D2 and D3 agonist
- Serves as an α2-adrenoceptors antagonist
- Inhibits MLL1 methyltransferase activity
- Potential for research in Parkinson's disease, circulatory disorders, and cancers