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Tocris Bioscience™ A 77-01 Catalog No.: 671225
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Tocris Bioscience™ A 77-01
GREENER_CHOICE

Catalog No. p-7161591
25 mg
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Quantity:
5 mg
25 mg
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Catalog No. 67-122-5

Supplier: Tocris Bioscience™ 6712/25

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Description

Potent inhibitor of TGF-βRI

A 77-01 is a potent TGF-βRI (ALK-5) inhibitor (IC50 = 34 nM). Inhibits TGF-β transcriptional activation. Inhibits TGF-β-induced proliferation of lung epithelial cells and SMAD phosphorylation. Inhibits TGF-β-induced epithelial-to-mesenchymal transition (EMT). Also inhibitor of p38 MAPK. Likely active metabolite of A 83-01 (Cat. No. 2939).
Greener Choice Claims
  • Environmental benefits include:
    • Ozone-Safe or Safe for the Ozone Layer

Specifications

Chemical Name or Material 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline
CAS 607737-87-1
Quantity 25 mg
Molecular Formula C18H14N4
Formula Weight 286.33
Purity 98%

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