Chromatography Standards
Medchemexpress LLC Nitisinone | 104206-65-7 | 99.93% | 1 ML
Nitisinone is an orally active, competitive, and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. It promotes tyrosine accumulation in a dose-dependent manner.
- Used in studies of hereditary tyrosinemia type 1 (HT-1)
- Used in studies of albinism
- Orally active
- Competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor
Medchemexpress LLC (R)-Ketorolac | 66635-93-6 | 99.7% | 10 MM 1 ML
(R)-Ketorolac is an orally active inhibitor of Cdc42 and Rac1. It inhibits GTPase and modifies ovarian cancer cell behaviors crucial for invasion and metastasis. This compound also ameliorates cancer-associated cachexia.
- Inhibits Cdc42 and Rac1
- Inhibits GTPase activity
- Modifies ovarian cancer cell behaviors for invasion and metastasis
- Ameliorates cancer-associated cachexia
- Decreases filopodia number and length
- Reduces cell adherence to fibronectin and collagen
- Prolongs survival in C26 tumour-bearing mice
- Alleviates C26-induced weight loss
- Prevents C26-induced T-lymphopenia
Medchemexpress LLC Norfloxacin | 70458-96-7 | 99.8% | 250 MG
Norfloxacin (Standard) is the analytical standard of Norfloxacin. This product is intended for research and analytical applications. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, functioning by inhibiting DNA gyrase. It is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Analytical standard
- Broad-spectrum antibiotic
- Active against Gram-positive and Gram-negative bacteria
- Inhibits DNA gyrase
- Suitable for research and analytical applications
- Used in HPLC, GC, and MS research experiments
Medchemexpress LLC Felodipine | 72509-76-3 | 99.83% | 50 MG
Felodipine is a dihydropyridine, a potent and vasoselective calcium channel antagonist. It effectively lowers blood pressure by targeting vascular smooth muscle, particularly in resistance vessels. This anti-hypertensive agent also possesses the ability to induce autophagy and can penetrate the blood-brain barrier.
- Potent vasoselective calcium channel antagonist
- Lowers blood pressure by acting on vascular smooth muscle
- Induces autophagy
- Able to cross the blood-brain barrier
Medchemexpress LLC Mifepristone (standard) | 84371-65-3 | 99.4% | 429.59 | 100 MG
Mifepristone (Standard) is an analytical standard of Mifepristone, also known as RU486. It functions as an antagonist for progesterone receptor (PR) and glucocorticoid receptor (GR), exhibiting IC50s of 0.2 nM and 2.6 nM respectively in in vitro assays. This product is designed for research and analytical applications.
- Intended for research and analytical applications
- Functions as a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS
- Serves as a reference standard supplied assay
Medchemexpress LLC Fostamatinib Disodium | 1025687-58-4 | 98.3% | 200 MG
Fostamatinib Disodium is an oral prodrug of the active compound R406. It acts as an orally available and competitive Syk/FLT3 inhibitor, also demonstrating inhibitory activity against Lyn and Lck. This compound is intended for research purposes only.
- Oral prodrug of R406
- Orally available
- Competitive Syk/FLT3 inhibitor (Ki of 30 nM, IC50 of 41 nM)
- Inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)
- Intended for research use only
Medchemexpress LLC Bretylium tosylate | 61-75-6 | 99.9% | 10 MG
Bretylium (tosylate) is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters. It acts as a sympathetic nerve and adrenergic ganglion blocking agent. It inhibits adrenergic function presynaptically only after an initial release in neurotransmitter substance.
- Inhibitor of presynaptic release of vasoconstrictor neurotransmitters.
- Acts as a sympathetic nerve and adrenergic ganglion blocking agent.
- Inhibits adrenergic function presynaptically.
Medchemexpress LLC Diphenhydramine (Standard) | 58-73-1 | 98.7% | 50 MG
Diphenhydramine (Standard) is the analytical standard of Diphenhydramine, intended for research and analytical applications. It is a first-generation histamine H1-receptor antagonist with anti-cholinergic effects. Diphenhydramine hydrochloride can cross the ovine blood-brain barrier (BBB). This compound is an analytical standard used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for research and analytical applications.
- First-generation histamine H1-receptor antagonist.
- Possesses anti-cholinergic effect.
- Diphenhydramine hydrochloride can cross the ovine blood-brain barrier (BBB).
- Commonly used in HPLC, GC, and MS for qualitative, quantitative, and methodological research experiments.
Medchemexpress LLC Hydrochlorothiazide | 58-93-5 | MFCD00051765 | 99.5% | 5 G
Hydrochlorothiazide (HCTZ) is an orally active thiazide diuretic that inhibits the TGF-β/Smad signaling pathway and has direct vascular relaxant effects. It improves cardiac function, reduces fibrosis, and exhibits an antihypertensive effect by reducing sodium reabsorption in the kidneys and lowering peripheral vascular resistance.
- Orally active diuretic agent
- Inhibits the TGF-β/Smad signaling pathway
- Direct vascular relaxant effects by opening KCA channels
- Improves cardiac function
- Reduces fibrosis
- Antihypertensive effect
- Reduces blood volume by decreasing sodium reabsorption
- Induces natriuresis and concomitant water loss
- Increases calcium reabsorption
Medchemexpress LLC Niclosamide (olamine) | 1420-04-8 | 98.7% | 5 G
Niclosamide olamine (BAY2353) is an orally active antihelminthic agent used in parasitic infection research. It is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide olamine has biological activities against cancer and inhibits DNA replication in Vero E6 cells.
- Functions as an orally active antihelminthic agent in parasitic infection research.
- Acts as a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells.
- Shows biological activity against cancer.
- Inhibits DNA replication in Vero E6 cells.
- Inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells.
- Inhibits STAT3-mediated luciferase reporter activity in HeLa cells.
- Inhibits virus replication in Vero E6 cells.
Medchemexpress LLC Sulfamerazine | 127-79-7 | 99.8% | 5 G
Sulfamerazine (RP-2632) is a sulfonamide antibacterial. It is a monomethyl derivative of sulfadiazine, specifically 2-sulfanilamido-4-methylpyrimidine. This sulfonamide drug inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes. Sulfamerazine is bacteriostatic in nature; its inhibition of dihydrofolic acid synthesis reduces the synthesis of bacterial nucleotides and DNA.
- Sulfonamide antibacterial.
- Monomethyl derivative of sulfadiazine.
- Inhibits bacterial synthesis of dihydrofolic acid.
- Competes with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.
- Bacteriostatic in nature.
- Reduces synthesis of bacterial nucleotides and DNA.
Medchemexpress LLC Betahistine dihydrochloride | 5579-84-0 | 99.8% | 5 G
Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. It is commonly used in the study of rheumatoid arthritis (RA).
- Orally active histamine H1 receptor agonist
- H3 receptor antagonist
- Used for the study of rheumatoid arthritis (RA)
- Inhibits [125I]iodoproxyfan binding to CHO cell membranes
- Regulates cAMP formation in CHO cells
- Attenuates severity of arthritis and reduces pro-inflammatory cytokines in paw tissues of CIA mice
- Ameliorates mouse CIA by decreasing joint destruction
Medchemexpress LLC Alverine citrate | 5560-59-8 | 99.49% | 5 G
Alverine citrate is a 5-HT1A receptor antagonist with an IC50 of 101 nM. It is a drug used for functional gastrointestinal disorders and acts directly on the muscle in the gut, causing it to relax. It suppresses the effect of 5-HTP, but not that of 8-OH-DPAT. This compound is suitable for various laboratory applications.
- Acts as a 5-HT1A receptor antagonist
- Used for functional gastrointestinal disorders
- Relaxes gut muscles directly
- Suppresses the effect of 5-HTP
- Has a high affinity for 5-HT1A receptors
Medchemexpress LLC Betahistine dihydrochloride | 5579-84-0 | 99.8% | 500 MG
Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and H3 receptor antagonist. It is used for the study of rheumatoid arthritis (RA).
- Orally active histamine H1 receptor agonist
- Histamine H3 receptor antagonist
- Inhibits [125I]iodoproxyfan binding to CHO cell membranes
- Regulates cAMP formation in CHO cells
- Increases tele-methylhistamine (t-MeHA) levels in vivo
- Attenuates the severity of arthritis in CIA mice
- Reduces pro-inflammatory cytokines in paw tissues
Perkin Elmer US LLC Metals in B100 Biodiesel - Ca, K, Mg, Na, P, 20 µg/g, 100mL
Matrix: Concentration: Volume: Content: B100 Biodiesel 20 µg/g 100 mL Ca, K, Mg, Na, P