Dimethyl Sulfoxide
Apexbio Technology LLC Ezetimibe 163222-33-1 10mM (in 1mL DMSO)
Ezetimibe (CAS 163222-33-1) is a cholesterol absorption inhibitor that targets the intestinal cholesterol transporter Niemann-Pick C1 Like 1 (NPC1L1) It reduces intestinal uptake of cholesterol and dietary carotenoids including - and -carotene lycopene lutein and -cryptoxanthin through downregulating transport proteins such as SR-BI ABCA1 NPC1L1 and transcription factors including SREBP-1/-2 and LXR- In ApoE-deficient mouse models ezetimibe significantly decreases plasma cholesterol levels and attenuates atherosclerotic lesion formation Clinically it lowers LDL cholesterol total cholesterol and triglycerides while elevating HDL cholesterol
Apexbio Technology LLC Atglistatin 1469924-27-3 10mM (in 1mL DMSO)
Atglistatin (CAS 1469924-27-3) is a small-molecule inhibitor selective for adipose triglyceride lipase (ATGL) an enzyme that catalyzes the rate-limiting step in triglyceride hydrolysis releasing fatty acids from cellular triglyceride stores Atglistatin inhibits ATGL activity competitively with an IC50 of 0 7 M and Ki of 355 nM In mouse white adipose tissue lysates atglistatin decreased triglyceride hydrolase activity by approximately 78% effectively reducing fatty acid and glycerol release This compound serves as a valuable tool in lipid metabolism and metabolic disease research
Apexbio Technology LLC Busulfan 55-98-1 10mM (in 1mL DMSO)
Busulfan is a DNA alkylating agent widely used in biomedical research as an anticancer compound It functions by forming cross-links on guanine bases within DNA leading to DNA damage and subsequent inhibition of cell growth and proliferation In vitro studies reveal that exposure to busulfan (IC50 range approximately 7 5 120 M) promotes cellular senescence in normal human fibroblast cell lines mediated through increased reactive oxygen species (ROS) and sustained activation of MAPK signaling pathways Additionally busulfan is utilized in fertility and reproductive biology research due to its ability to induce apoptosis in male germ cells reducing germ cell populations in experimental mouse models
Apexbio Technology LLC Halcinonide 3093-35-4 10mM (in 1mL DMSO)
Halcinonide (CAS 3093-35-4) is a potent synthetic corticosteroid widely utilized in biomedical research as a topical anti-inflammatory agent Mechanistically halcinonide exerts biological effects primarily through activation of glucocorticoid receptor pathways subsequently modulating gene transcription and suppressing the release of inflammatory mediators Owing to its robust corticosteroid receptor agonism and pronounced anti-inflammatory properties this compound frequently supports investigations into inflammatory dermatological conditions and glucocorticoid signaling pathways
Apexbio Technology LLC ML216 1430213-30-1 10mM (in 1mL DMSO)
ML216 (CAS 1430213-30-1) is a small molecule inhibitor targeting Bloom (BLM) helicase a DNA unwinding enzyme essential for homologous recombination-mediated DNA repair ML216 inhibits DNA unwinding activity of full-length BLM (IC50 3 0 M) and a truncated form BLM636-1298 (IC50 0 97 M) displaying sub-micromolar selectivity relative to other helicases such as RECQ1 RECQL5 and bacterial UvrD In cellular assays ML216 selectively suppresses proliferation in BLM-containing fibroblasts increasing sister chromatid exchange frequency consistent with BLM functional deficiency By inhibiting BLM helicase ML216 may sensitize tumor cells to conventional DNA-damaging therapeutics indicating potential application in cancer research and therapy development
Medchemexpress LLC Carbocysteine sulfoxide | 5439-87-2 | 195.19 | C5H9NO5S | 5 MG
Carbocysteine sulfoxide is a carbocisteine impurity and drug intermediate provided for research use only. The compound has formula C5H9NO5S, molecular weight 195.19, and CAS number 5439-87-2. It is intended for analytical reference, impurity profiling, and synthetic studies in laboratory research and is not for clinical, diagnostic, or therapeutic use.
- Used as an analytical reference material for method validation.
- Useful for impurity profiling and degradation studies.
- Suitable as a synthetic intermediate in research workflows.
- Provided in small, accurately measured quantities for laboratory experiments.
- Intended strictly for research use; not for human or animal administration.
Apexbio Technology LLC Everolimus (RAD001) 159351-69-6 10mM (in 1mL DMSO)
Everolimus (RAD001) is an orally bioavailable small-molecule inhibitor targeting mammalian target of rapamycin (mTOR) an integral serine/threonine kinase regulating cell proliferation metabolism and survival within the PI3K/Akt pathway Everolimus binds intracellularly to the immunophilin FKBP12 the resulting complex subsequently interacts directly with mTOR inhibiting its kinase activity thereby reducing downstream phosphorylation of S6 kinase 1 (S6K1) and the eukaryotic initiation factor 4E-binding protein (4EBP) Functionally Everolimus exerts immunosuppressive properties used clinically to prevent organ transplant rejection and demonstrates antitumor activity against several malignancies including renal cell carcinoma and basal cell carcinoma Commonly utilized in cancer research Everolimus inhibits mTOR with IC50 values reported in the low nanomolar range ( 1 3 nM)
Cayman Chemical L-MethIonIn SulfoxIde 5g
A sulfoxide-modified methionine; increases weight gain in weanling mice in the diet at 6.3, 12.6, and 18.9 mmol/g; levels are decreased in patients with vitiligo
Apexbio Technology LLC Calcipotriol 112965-21-6 10mM (in 1mL DMSO)
Calcipotriol is a synthetic analogue of vitamin D3 known to bind and activate the vitamin D receptor (VDR) Upon binding to VDR Calcipotriol modulates gene transcription involved in cellular differentiation and proliferation pathways This compound demonstrates regulatory effects on immune cells particularly T cells implicated in psoriasis pathogenesis and induces apoptosis in keratinocytes isolated from psoriasis lesions Calcipotriol also triggers autophagic processes in keratinocytes and HeLa cells in vitro Additionally it suppresses proliferation of various human tumor cell lines including HL-60 and MCF-7 in a concentration-dependent manner In research settings Calcipotriol is used to study differentiation proliferation and inflammatory responses of keratinocytes and immune-related cell types
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 500mL
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1] br/ Low endotoxin can be used in various biochemical experiments such as drug dissolution
Apexbio Technology LLC Y-27632 146986-50-7 10mM (in 1mL DMSO)
Y-27632 (CAS 146986-50-7) is a selective inhibitor of Rho-associated protein kinases (ROCK) specifically targeting ROCK1 and ROCK2 isoforms It competitively binds to the ATP-binding site inhibiting ROCK1 and ROCK2 with Ki values of 0 22 M and 0 30 M respectively Compared to other kinases such as citron kinase PKN and PKC Y-27632 exhibits significantly higher selectivity toward ROCK isoforms In cellular assays Y-27632 at 10 M concentration effectively disrupts stress fiber formation in Swiss 3T3 fibroblast cells It is widely used in cell biology research to study ROCK signaling pathways and cytoskeletal dynamics
Hampton Research 30% V/V DIMETHYL SULFOX 1ML
HR2-428-28/Additive Screen 28 (C04), 1.0 ml - 30% v/v Dimethyl sulfoxide. Please note items from this supplier are non-returnable.
Apexbio Technology LLC DMXAA (Vadimezan) 117570-53-3 10mM (in 1mL DMSO)
DMXAA (Vadimezan AS-1404) is a tumor vascular disrupting and apoptosis-inducing agent functioning primarily through inhibition of DT-diaphorase (DTD) It acts by suppressing DTD enzymatic activity showing an IC50 of approximately 62 5 M Additionally DMXAA inhibits various kinases notably VEGFR2 disrupting endothelial cells and blood vessel formation to induce tumor cell apoptosis and vascular necrosis Experimentally DMXAA demonstrates activity in murine tumor models including induction of apoptosis in endothelial cells and tumor vasculature promoting necrosis and tumor regression Therefore DMXAA is commonly used in oncology research focused on anti-angiogenesis and tumor vascular disruption mechanisms
Apexbio Technology LLC Dapivirine (TMC120) 244767-67-7 10mM (in 1mL DMSO)
Dapivirine (TMC120) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1 viral replication By binding directly to HIV-1 reverse transcriptase dapivirine inhibits viral RNA-dependent DNA polymerase activity thus blocking viral DNA synthesis Dapivirine demonstrates activity against HIV-1 reverse transcriptase with reported IC50 values in the low nanomolar range (approximately 1-10 nM) Due to its molecular specificity and promising in vitro antiviral profile dapivirine is widely utilized in biomedical research exploring topical prevention strategies particularly in the development of vaginal microbicides aimed at reducing HIV transmission