Dimethyl Sulfoxide
Apexbio Technology LLC AEBSF.HCl 30827-99-7 10mM (in 1mL DMSO)
AEBSF HCl is an irreversible serine protease inhibitor that covalently binds and inhibits several proteases including trypsin chymotrypsin plasmin and thrombin It has been applied in cellular research to study amyloid-beta (A ) production mechanisms In APP695 (K695sw)-transfected K293 cells AEBSF dose-dependently reduces A formation with an IC50 around 1 mM while in wild-type APP695-transfected HS695 and SKN695 cells it shows inhibitory effects with an IC50 of approximately 300 M Besides suppressing -cleavage AEBSF promotes -cleavage of APP In macrophage-mediated leukemic cell lysis assays incubation with AEBSF at 150 M for 6 hours achieves near-maximal protease inhibition thus impeding cell lysis
Apexbio Technology LLC Dioscin 19057-60-4 10mM (in 1mL DMSO)
Dioscin (CAS 19057-60-4) is a steroidal saponin isolated primarily from Dioscorea nipponica Makino Structurally it belongs to glycosidic steroid derivatives known for modulating various biological pathways Dioscin exerts bioactivity predominantly through regulation of cellular signaling cascades such as apoptosis induction anti-inflammatory responses and oxidative stress reduction Studies suggest that dioscin interacts with signaling pathways including PI3K/Akt ERK/MAPK and NF- B Due to these activities dioscin is commonly investigated for its potential anti-inflammatory anticancer and antioxidant effects making it relevant for biomedical research focused on chronic inflammation and cancer therapeutics
Apexbio Technology LLC Decernotinib(VX-509) 944842-54-0 10mM (in 1mL DMSO)
Decernotinib (VX-509) is an orally bioavailable inhibitor targeting Janus kinase 3 (JAK3) with additional inhibitory activities toward JAK1 JAK2 and TYK2 (Ki values JAK3 2 nM JAK1 11 nM JAK2 13 nM TYK2 11 nM) Janus kinases are intracellular tyrosine kinases critical for cytokine-mediated signal transmission involved notably in immune cell activation and inflammatory responses By inhibiting JAK-mediated STAT5 phosphorylation VX-509 modulates cytokine-dependent lymphocyte proliferation and activation This compound has been employed in preclinical models exploring therapeutic potential in autoimmune conditions and inflammatory disorders such as rheumatoid arthritis
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 500 mL
Dimethyl sulfoxide | Purity: ≥99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500 mL
Apexbio Technology LLC Nisoldipine 63675-72-9 10mM (in 1mL DMSO)
Nisoldipine (CAS 63675-72-9) is a dihydropyridine-based calcium channel blocker selective for the voltage-dependent L-type calcium channel Cav1 2 It inhibits Cav1 2-mediated calcium influx with an IC50 of approximately 10 nM By modulating calcium entry nisoldipine is frequently utilized in cardiovascular research to study vascular smooth muscle contraction calcium signaling pathways and cardiovascular pharmacology Its selective blockade helps elucidate the functional importance of Cav1 2 channels under physiological and pathological conditions
Apexbio Technology LLC Ponatinib (AP24534) 943319-70-8 10mM (in 1mL DMSO)
Ponatinib (AP24534 CAS 943319-70-8) is a second-generation small molecule inhibitor targeting the BCR-ABL fusion kinase The BCR-ABL fusion arising from a t(9 22) chromosomal translocation encodes oncogenic tyrosine kinase variants implicated in chronic myeloid leukemia (CML) acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) Ponatinib inhibits both wild-type BCR-ABL (IC50 0 5 nM) and resistant mutants notably the T315I mutant (IC50 11 nM) Additionally it potently inhibits clinically relevant kinases such as RET FLT3 KIT PDGFR / and FGFR1 Ponatinib is utilized in cancer biology research pertaining to kinase-driven malignancies
Apexbio Technology LLC Sorafenib(Synonyms: Nexavar, BAY 43-9006, BAY-43-9006, BAY439006, Sorafenib Tosylate, BAY-545-9085), 10mM (in 1mL DMSO), CAS: 284461-73-0.
Sorafenib (CAS 284461-73-0) is an orally bioavailable small molecule inhibitor targeting multiple kinases including Raf kinase as well as receptor tyrosine kinases such as VEGFR2 PDGFR FLT3 Ret and c-Kit By inhibiting Raf signaling pathways sorafenib suppresses tumor cell proliferation induces apoptosis and disrupts tumor angiogenesis In vitro studies demonstrate that sorafenib effectively inhibits Raf-mediated signaling cascades and blocks the proliferation of tumor cells Sorafenib serves as an important research tool in the study of cancer biology particularly in investigating antiangiogenic and antiproliferative mechanisms in various tumor models
Apexbio Technology LLC c-Myc tag Peptide 2918768-02-0 10mM (in 1mL DMSO)
c-Myc tag peptide is a synthetic peptide with the amino acid sequence EQKLISEEDL corresponding to residues 410-419 at the C-terminal region of human c-Myc protein It serves as an epitope tag for recombinant protein expression enabling specific recognition and purification of fusion proteins using anti-c-Myc antibodies In immunoassays the peptide competitively binds to anti-c-Myc antibodies confirming antibody-antigen binding specificity and facilitating analysis of fusion proteins in Western blotting immunoprecipitation and immunofluorescence experiments c-Myc itself encodes a transcription factor regulating cellular processes such as proliferation growth apoptosis differentiation and stem-cell renewal pathways and is frequently overexpressed in cancers
Apexbio Technology LLC QNZ (EVP4593) 545380-34-5 10mM (in 1mL DMSO)
QNZ (EVP4593 CAS number 545380-34-5) is a quinazoline-derived small molecule inhibitor of the NF- B signaling pathway Originally identified using a luciferase reporter assay in human Jurkat T cells QNZ effectively suppresses PMA/PHA-induced NF- B transcriptional activation (IC50 11 nM) and TNF- production (IC50 7 nM) Additionally QNZ demonstrates anti-inflammatory properties reducing edema formation in a carrageenan-induced rat paw swelling model In Huntington s disease research QNZ improved motor performance in transgenic fly models without toxicity suggesting potential neuroprotective applications
Apexbio Technology LLC SL-327 305350-87-2 10mM (in 1mL DMSO)
SL-327 (CAS 305350-87-2) is a selective inhibitor targeting MEK1 and MEK2 kinases exhibiting IC50 values of 0 18 M and 0 22 M respectively MEK1/2 mediate the phosphorylation and activation of extracellular signal-regulated kinases (ERK) crucial components of the MAPK/ERK signaling pathway SL-327 treatment lowers phosphorylated ERK levels and subsequent activation of transcription factors including CREB Elk-1 and c-Fos influencing gene expression linked to synaptic plasticity In animal models SL-327 modulates drug-induced behaviors and neuronal plasticity processes making it a relevant molecular tool to investigate MAPK/ERK signaling pathways in neuroscience research
Apexbio Technology LLC Ezatiostat hydrochloride 286942-97-0 10mM (in 1mL DMSO)
Ezatiostat hydrochloride (CAS 286942-97-0) also known as TLK199 is a small-molecule inhibitor primarily targeting glutathione S-transferase (GST) specifically the GST P1-1 isoform GST P1-1 typically suppresses the Jun N-terminal kinase (JNK) signaling pathway thus Ezatiostat hydrochloride through GST P1-1 inhibition activates JNK signaling In preclinical research this activation has been associated with increased proliferation maturation and differentiation of hematopoietic precursor cells Additionally Ezatiostat hydrochloride induces growth arrest and apoptosis in human leukemia HL-60 cells (CC50 approximately 6-17 M) It holds potential for treating cytopenias and hematological disorders
Apexbio Technology LLC Tetracaine HCl 136-47-0 10mM (in 1mL DMSO)
Tetracaine hydrochloride (CAS 136-47-0) is a small molecule local anesthetic commonly used in biomedical research It acts through allosteric modulation of ion channel function specifically inhibiting calcium channels and effectively suppressing voltage-dependent calcium release from the sarcoplasmic reticulum Due to its ability to regulate calcium channel activity tetracaine HCl serves as an important investigative tool in studies exploring calcium signaling pathways muscle physiology and neuronal excitability
Apexbio Technology LLC Quercetin(Synonyms: Sophoretin, Meletin, Quercetine, 3,3',4',5,7-Pentahydroxyflavone, Quercetol, Xanthaurine), 10mM (in 1mL DMSO), CAS: 117-39-5.
Quercetin (CAS 117-39-5) is a dietary flavonoid widely found in fruits vegetables nuts tea and red wine exhibiting notable antineoplastic and anti-inflammatory effects It functions primarily as a potent inhibitor of intracellular signaling kinases including PI3K and NF- B and moderately inhibits Akt1/2 with weaker effects on PKC p38 and ERK1/2 pathways Moreover quercetin can elevate cytosolic Ca levels disrupt mitochondrial membrane potential induce cytochrome c release and activate caspases (3 8 and 9) thereby promoting apoptosis through mitochondrial pathways It also affects cell cycle progression and apoptosis via stabilizing and phosphorylating p53 Thus quercetin serves as a valuable tool in cancer research providing insights into chemoprevention mechanisms and therapeutic potentials
Apexbio Technology LLC Cilengitide 188968-51-6 10mM (in 1mL DMSO)
Cilengitide (CAS 188968-51-6) is a cyclic RGD pentapeptide [Arg-Gly-Asp-DPhe-(NMeVal)] that acts as an inhibitor of integrins v 3 and v 5 These integrins are transmembrane receptors mediating cellular processes such as adhesion migration angiogenesis and invasion Cilengitide binds directly to v 3 integrin receptors inhibiting integrin-mediated activities with an IC50 of 250 nM In in vitro assays cilengitide dose-dependently reduces proliferation and adhesion of endothelial progenitor cells In vivo studies showed that cilengitide administration significantly lowered osteolytic lesion formation and soft tissue involvement in metastatic MDA-MB-231 tumor models
Apexbio Technology LLC SAR245409 (XL765) 1349796-36-6 10mM (in 1mL DMSO)
SAR245409 (XL765 CAS 1349796-36-6) is a selective dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with high potency against PI3K (IC50 9 nM) It suppresses the PI3K/Akt/mTOR signaling cascade by preventing formation of phosphatidylinositol-3 4 5-triphosphate (PIP3) at the cell membrane and downstream phosphorylation of AKT p70S6 kinase and S6 SAR245409 demonstrates antitumor activity in cancer models exhibiting genetic alterations in PI3K pathways enhancing growth suppression and apoptosis It is commonly employed in preclinical studies evaluating PI3K/mTOR-targeted approaches in cancer therapy