Dimethyl Sulfoxide
Apexbio Technology LLC PCI-34051(Synonyms: PCI 34051, PCI34051, HDAC8 inhibitor PCI-34051, PCI-34051 HDAC inhibitor), 10mM (in 1mL DMSO), CAS: 950762-95-5.
PCI-34051 (CAS 950762-95-5) is a selective inhibitor of histone deacetylase 8 (HDAC8) with over 200-fold specificity compared to other HDAC isoforms including HDAC1 HDAC2 HDAC3 HDAC6 and HDAC10 Through selective HDAC8 inhibition PCI-34051 preferentially triggers caspase-dependent apoptosis in T-cell lymphoma and leukemia-derived cell lines while sparing normal hematopoietic (e g PBMCs) and fibroblast cells Cell death induction by PCI-34051 occurs without detectable histone or tubulin hyperacetylation This compound serves as a valuable research tool for dissecting HDAC8-related pathways and evaluating therapeutic potential for hematologic malignancies
Apexbio Technology LLC VX-661(Synonyms: Tezacaftor, VX661, VX-661, VX 661), 10mM (in 1mL DMSO), CAS: 1152311-62-0.
VX-661 (CAS 1152311-62-0) is a small-molecule CFTR corrector developed by Vertex Pharmaceuticals designed to restore trafficking and enhance cellular surface expression of the mutated F508del-CFTR protein By facilitating proper folding and transport of this commonly mutated cystic fibrosis transmembrane conductance regulator (CFTR) VX-661 increases CFTR-mediated chloride channel activity in vitro Preclinical and clinical research have explored VX-661 alone and in combination with ivacaftor demonstrating enhanced F508del-CFTR functionality and providing a promising strategy for addressing cystic fibrosis caused by the F508del mutation
Apexbio Technology LLC Oseltamivir 196618-13-0 10mM (in 1mL DMSO)
Oseltamivir is a neuraminidase inhibitor targeting influenza virus replication It functions as a prodrug metabolized into oseltamivir carboxylate by host esterases This active metabolite binds to viral neuraminidase thereby blocking cleavage of terminal -Neu5Ac residues and subsequent viral progeny release from infected host cells Oseltamivir has been widely employed in investigative studies addressing antiviral efficacy resistance mechanisms and clinical outcomes in influenza infection research The compound is frequently used in vitro to characterize neuraminidase activity inhibition typically reporting IC50 values in the low nanomolar range (approximately 0 1-5 nM) depending on the influenza viral strain and assay conditions influencing viral replication and transmission
Gold Biotechnology Inc Sterile Filtered DMSO
Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds DMSO is also used as a cryoprotectant for cell media preventing the formation of ice crystals which would otherwise damage cells DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification especially for DNA sequences which have GC rich sequences
Medchemexpress LLC HY-Y0320 100mL , Dimethyl sulfoxide CAS:67-68-5 Purity:>98%
HY-Y0320 100mL Dimethyl sulfoxide CAS: 67-68-5 Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds. Dimethyl sulfoxide has anti-freezing and bacteriostatic properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
FUJIFILM Biosciences CultureSure DMSO
This product is DMSO dimethyl sulfoxide for cell culture It can be used to dissolve compounds added to culture media and to prepare cryopreservation solutions
Sigma Aldrich Fine Chemicals Biosciences DIMETHYL SULFOXIDE 5X10ML
NC3592570 DIMETHYL SULFOXIDE 5X10ML
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 | C2H6OS | 200mL
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1] br/ Low endotoxin can be used in various biochemical experiments such as drug dissolution
Medchemexpress LLC Dimethyl sulfoxide (GMP like) | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 100mL
Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C) Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1]