Dimethyl Sulfoxide
Apexbio Technology LLC Silymarin 22888-70-6 10mM (in 1mL DMSO)
Silymarin (CAS 22888-70-6) is a naturally occurring flavonoid complex derived from the seeds of plants belonging to the Asteraceae family notably milk thistle (Silybum marianum) This phytochemical mixture exerts cellular antioxidant and anti-inflammatory activities primarily by inhibiting lipid peroxidation scavenging free radicals stabilizing cell membranes and modulating intracellular signaling pathways linked to oxidative stress response In biomedical research silymarin is extensively studied for hepatoprotective properties and its potential applications in investigating liver injury hepatotoxicity models and oxidative stress-mediated cellular damage The compound can be appropriately dissolved in solvents such as methanol ethanol acetone or ethyl acetate and requires storage under dry cool and sealed conditions
Apexbio Technology LLC JIB-04 199596-05-9 10mM (in 1mL DMSO)
JIB-04 (CAS 199596-05-9) is a selective small-molecule inhibitor targeting Jumonji histone demethylases specifically suppressing enzymes including JARID1A JMJD2 family members (JMJD2A-E) and JMJD3 Structurally categorized as a pyridine hydrazone derivative JIB-04 inhibits demethylase activity independently of competitive binding with -ketoglutarate In vitro assays revealed IC50 values ranging from 230 nM to 1100 nM across various Jumonji enzymes Additionally JIB-04 demonstrates preferential inhibition of cancer cell proliferation versus normal cells notably in lung and prostate cancer cell lines and effectively reduces tumor growth in mouse xenograft models highlighting its relevance for cancer research
Apexbio Technology LLC Dynasore 304448-55-3 10mM (in 1mL DMSO)
Dynasore is a non-competitive inhibitor targeting dynamin family GTPases including dynamin1 dynamin2 and Drp1 with an IC50 of approximately 15 M Dynamin GTPases mediate membrane fission processes required for endocytosis and intracellular vesicle trafficking through catalyzing GTP hydrolysis Dynasore inhibits dynamin-mediated endocytic pathways by blocking GTPase activity thus preventing vesicle scission during endocytosis In biological research dynasore is frequently used to investigate dynamin-dependent endocytosis in cellular and neuronal models facilitating studies on synaptic vesicle recycling membrane trafficking and signaling dynamics
Apexbio Technology LLC Ro 3306 872573-93-8 10mM (in 1mL DMSO)
Ro 3306 (CAS 872573-93-8) is an ATP-competitive inhibitor targeting cyclin-dependent kinase 1 (CDK1) It selectively inhibits CDK1/cyclin B1 and CDK1/cyclin A complexes (Ki values of 35 nM and 110 nM respectively) thereby interfering with mitotic entry In DU145 cells Ro 3306 at 1 M diminishes BRCA1 localization at DNA double-strand breaks and suppresses RAD51 foci formation sensitizing these cells to DNA-damaging agents such as AZ12253801 Hence Ro 3306 is useful in studying cell cycle regulation DNA repair mechanisms and sensitization of cancer cells to targeted therapies
Apexbio Technology LLC Y-27632 dihydrochloride 129830-38-2 10mM (in 1mL DMSO)
Y-27632 dihydrochloride (CAS 129830-38-2) is a small-molecule inhibitor targeting ROCK kinases (Rho-associated protein kinases) specifically interacting with the catalytic domains of ROCK-1 and ROCK-2 It inhibits their kinase activity with an IC50 of approximately 140 nM By targeting ROCK signaling Y-27632 disrupts Rho-mediated formation of cellular stress fibers influences cell cycle progression from G1 to S phase and interferes with cytokinesis It is commonly utilized in studies investigating cell proliferation cytoskeletal organization and stem cell viability
Apexbio Technology LLC Ticagrelor 274693-27-5 10mM (in 1mL DMSO)
Ticagrelor (CAS 274693-27-5) is an orally active reversible antagonist targeting the platelet P2Y12 receptor By competitively binding to P2Y12 ticagrelor inhibits ADP-mediated platelet aggregation resulting in dose-dependent suppression of platelet activation and thrombosis in vitro Unlike other P2Y12 inhibitors requiring metabolic activation ticagrelor acts without metabolic transformation though it is primarily metabolized by CYP3A4 and CYP2C19 enzymes This compound is frequently employed in biomedical research exploring platelet function thrombosis mechanisms and drug-drug interactions involving cytochrome P450 enzymes
Apexbio Technology LLC Edaravone 89-25-8 10mM (in 1mL DMSO)
Edaravone (CAS 89-25-8) is a small-molecule antioxidant and free radical scavenger that mitigates cell injury primarily by intercepting reactive oxygen species and suppressing oxidative stress responses Its cytoprotective mechanism has been linked to the inhibition of lipid peroxidation pathways potentially involving suppression of lipoxygenase activity Edaravone has been investigated for neuroprotective effects notably demonstrating protection against neurotoxicity induced by MPTP a well-established model to study Parkinson s disease pathology This compound serves as a significant research tool for examining oxidative injury in ischemic and neurodegenerative conditions
Apexbio Technology LLC Triptolide 38748-32-2 10mM (in 1mL DMSO)
Triptolide (CAS 38748-32-2) is a biologically active diterpenoid originally isolated from the traditional Chinese herb Tripterygium wilfordii It exerts inhibitory effects by suppressing interleukin-2 expression in activated T cells and impeding NF- B-mediated transcriptional activation Triptolide inhibits invasion and migration of ovarian cancer cells via reducing matrix metalloproteinases MMP-7 and MMP-19 expression and enhancing E-cadherin expression Additionally it induces RNA polymerase II degradation leading to apoptosis and reduced proliferation in cancer cell lines and rheumatoid arthritis synovial fibroblasts Consequently triptolide serves as a valuable tool for immunology oncology and inflammation research
Apexbio Technology LLC MC1568 852475-26-4 10mM (in 1mL DMSO)
MC1568 (CAS 852475-26-4) is a histone deacetylase (HDAC) inhibitor derived from the (aryloxopropenyl)pyrrolyl hydroxyamide chemical class It selectively targets class II HDAC enzymes particularly class IIa subtypes (HDAC4 HDAC5 HDAC7 HDAC9) inhibiting maize class II HDAC activity with an IC50 of 22 M MC1568 modulates muscle differentiation pathways by reducing MEF2D expression stabilizing HDAC-HDAC3-MEF2D complexes and preventing MEF2D acetylation in cultured myocytes It also interferes with differentiation signals mediated via RAR and PPAR nuclear receptors serving as a valuable tool in epigenetic and cellular differentiation studies
Apexbio Technology LLC Prednisolone 50-24-8 10mM (in 1mL DMSO)
Prednisolone is a synthetic glucocorticoid structurally derived from cortisol characterized by anti-inflammatory and immunosuppressive properties Through binding to intracellular glucocorticoid receptors prednisolone modulates gene expression leading to inhibition of pro-inflammatory cytokine production suppression of immune cell proliferation and attenuation of inflammatory mediators In biomedical research prednisolone is commonly employed to investigate inflammatory pathways autoimmune responses and immune regulation mechanisms Additionally it serves as a reference compound in the screening and evaluation of novel anti-inflammatory and immunomodulatory therapeutics
AdipoGen DAF-4T Solution 5 mM in DMSO
Chemical. CAS 212558-80-0. Formula C20H7Cl2N3O5. MW 440.19. Fluorescent reference compound for DAF-4 DA CDX-D0216. Spectral data lambdaEx=505nm lambdaEm=530nm.
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide puriss500ML
Dimethyl sulfoxide (DMSO) is a polar solvent. DMSO activated by electrophile (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. It has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction due to its high stability.
Supply Solutions Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100ml
Dimethyl sulfoxide | Purity: ?99.7%% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 100ml