Benzenoids
Medchemexpress LLC Amifampridine (3,4-Diaminopyridine) | 54-96-6 | 99.99% | 109.13 | 10 G
Amifampridine (3,4-Diaminopyridine) is an orally active, potent, and cell-permeable voltage-gated potassium (Kv) channel blocker (PCB). It is effective in reversing BoNT/A intoxication and increases transmitter release from neuromuscular junctions (NMJs). It can be utilized for research into Lambert-Eaton myasthenic syndrome (LEMS).
- Potent and cell-permeable voltage-gated potassium (Kv) channel blocker
- Effective in reversing BoNT/A intoxication
- Increases transmitter release from neuromuscular junctions
- Suitable for Lambert-Eaton myasthenic syndrome (LEMS) research
Medchemexpress LLC C14-4 | 2639634-80-1 | 99.01% | 1365.30 | 1 ML
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). It enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity.
- Used for synthesis of lipid nanoparticles (LNPs)
- Enhances mRNA delivery to primary human T cells
- Induces functional protein expression
- Exhibits high transfection efficiency
- Maintains low cytotoxicity
- Appearance: liquid
- Color: colorless to light yellow
- Pure form storage: -20°C for 3 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Solubility in ethanol: 100 mg/mL
- Solubility in DMSO: 100 mg/mL
Medchemexpress LLC Nrf2 activator-4 | 2383016-68-8 | 98.03% | 468.90 | 1 ML
Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 μM. It suppresses reactive oxygen species against oxidative stress in microglia and effectively recovers learning and memory impairment in a scopolamine-induced mouse model.
- Highly potent and orally active Nrf2 activator
- EC50 of 0.63 μM
- Suppresses reactive oxygen species against oxidative stress in microglia
- Effectively recovers learning and memory impairment in a scopolamine-induced mouse model
- Light yellow to yellow solid appearance
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC 1,4-Benzenediacetic acid | 7325-46-4 | 96.8% | 194.19 | 25 G
1,4-Benzenediacetic acid is a chemical compound with the molecular formula C10H10O4 and a molecular weight of 194.19. It typically appears as an off-white to light brown solid and has a purity of 96.84% as determined by HPLC. This product is suitable for various laboratory applications requiring a chemical with these specifications.
- High purity of 96.84% (HPLC)
- Off-white to light brown solid appearance
- Molecular formula C10H10O4
- Molecular weight 194.19
- Recommended storage for powder: -20°C for 3 years, 4°C for 2 years
- Recommended storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Docosanoic acid | 112-85-6 | 99.4% | 340.59 | 10 G
Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid that inhibits the double-stranded DNA (dsDNA) binding activity of the p53 DNA binding domain with a Kd of 12 nM. It has low bioavailability and can increase cholesterol in humans.
- Inhibits dsDNA binding activity of wild-type p53 DBD with 50% inhibition at 0.41 nmol.
- Affects cholesterol levels in humans.
- Impacts fat deposition in rats, reducing visceral fat and increasing fatty acid excretion.
- Low bioavailability leads to reduced absorption and body weight in rats.
Medchemexpress LLC Tetracycline | 60-54-8 | 98.0% | C22H24N2O8 | 50 G
Tetracycline is a broad-spectrum antibiotic with oral activity, effective against a wide range of bacteria, including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, and rickettsiae. It is suitable for research on infections and in animal modeling for genetically engineered disease models.
- Broad-spectrum oral antibiotic.
- Effective against gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, and rickettsiae.
- Suitable for infection research.
- Inhibits L-amyloid aggregate formation.
- Used in animal modeling to create genetically engineered disease models.
- Can induce tumor regression in mice by inhibiting BCR-ABL expression.
Medchemexpress LLC Edaravone | 89-25-8 | MFCD00003138 | >99% | C10H10N2O | 10 G
Edaravone is a potent free radical scavenger, noted for its ability to inhibit MMP-9-related brain hemorrhage. It is also used to ameliorate symptoms of amyotrophic lateral sclerosis (ALS). For storage, keep at -20°C in a sealed container, away from moisture.
- Attenuates ferroptosis and reduces lipid peroxidation in cells.
- Increases glutathione levels and inhibits xCT protein level decrease.
- Enhances antioxidant enzyme activities and upregulates glutathione peroxidase.
- Improves motor function and survival in ALS mouse models.
- Suppresses neuroinflammation and microglial activation.
- Improves mitochondrial integrity and function.
- Reduces early brain injury and brain edema in intracerebral hemorrhage models.
Medchemexpress LLC trans-4-Hydroxycyclohexanecarboxylic acid | 3685-26-5 | 98.0% | C7H12O3 | 5 G
trans-4-Hydroxycyclohexanecarboxylic acid is a high-purity chemical compound, presenting as a white to off-white solid with a purity of 98.0%. Its chemical formula is C7H12O3 and its CAS number is 3685-26-5. This compound serves as a substrate in the production of cyclohexanecarboxylic acid. Furthermore, it is recognized as a by-product of intestinal bacterial metabolism, which is excreted via urine. With a molecular weight of 144.17, it is classified under ketones, aldehydes, and acids, and originates as an endogenous metabolite.
- High-purity chemical compound
- White to off-white solid appearance
- Serves as a substrate in the production of cyclohexanecarboxylic acid
- Recognized as a by-product of intestinal bacterial metabolism
- Classified under ketones, aldehydes, and acids
- Originates as an endogenous metabolite
- Good solubility in DMSO, with a concentration of 100 mg/mL (693.63 mM)
Medchemexpress LLC Yeast extract | 8013-01-2 | 50 G
Yeast extract, derived from *Saccharomyces cerevisiae*, is a concentrate of soluble yeast components. It is a rich source of nutritional elements including partially hydrolyzed proteins, free amino acids, B vitamins, and minerals. This versatile ingredient offers both nutritional and flavoring properties, and research suggests it can promote wound healing.
- Rich in nutritional components, including partially hydrolyzed proteins, free amino acids, B vitamins, and minerals
- Acts as a food ingredient for nutritional and flavoring purposes
- Promotes wound healing in various models
- Supports rapid growth and cell viability in specific Rhizobium species
- Accelerates wound closure and cellular reorganization in diabetic mice wound models
Medchemexpress LLC 4-hydrazinobenzoic acid | 619-67-0 | MFCD00007581 | 100.0% | 152.15 g/mol | C7H8N2O2 | 50 G
4-hydrazinobenzoic acid is an organic biochemical reagent used as a building block in organic synthesis and as an analytical standard in life-science research. It is supplied as a yellow-brown solid and is characterized by CAS 619-67-0 and molecular formula C7H8N2O2.
- High purity suitable for analytical and synthetic applications.
- Solid form, yellow to brown, easy to handle and weigh.
- Stable when stored under recommended conditions for long-term use.
- Supplied with certificate of analysis and safety data sheet for documentation.
- Commonly used as a building block in organic synthesis and as an analytical standard.
Medchemexpress LLC Phenol, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- | 269409-70-3 | 220.08 | 100 G
4-Hydroxyphenylboronic acid pinacol ester is a ROS-responsive component. It can structurally modify hyaluronic acid to prepare ROS-responsive intelligent nanocarriers and compound delivery systems. It endows hyaluronic acid-based nanocarriers with ROS responsiveness, enabling them to rapidly release encapsulated Curcumin in the presence of reactive oxygen species. This product is applicable to research related to periodontitis and can also be used for the synthesis of boronic acid-modified resins.
- ROS-responsive component
- Can structurally modify hyaluronic acid to prepare ROS-responsive intelligent nanocarriers and compound delivery systems
- Endows hyaluronic acid-based nanocarriers with ROS responsiveness, allowing for rapid release of encapsulated curcumin in the presence of reactive oxygen species
- Research related to periodontitis
- Synthesis of boronic acid-modified resins
Medchemexpress LLC 4-Bromophenylacetylene | 766-96-1 | 181.03 | 10 MM * 1 ML
1-Bromo-4-ethynylbenzene is a biochemical reagent suitable for life science-related research, functioning as both a biological material and an organic compound. It serves as a click chemistry reagent, possessing an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Biochemical reagent for life science research.
- Usable as a biological material or organic compound.
- Acts as a click chemistry reagent.
- Contains an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules.
- Serves as a starting material for creating second-order nonlinear optical materials, heterocyclotriynes, and unsymmetrical 1,4-diarylbutadiynes.
Medchemexpress LLC 4-Vinylphenol | 2628-17-3 | 120.15 | 1 ML
4-Vinylphenol is a compound found in the medicinal herb Hedyotis diffusa Willd and wild rice. It is also a metabolite of p-coumaric and ferulic acid produced by lactic acid bacteria in wine. This compound induces apoptosis, inhibits blood vessel formation, and suppresses invasive breast tumor growth in vivo.
- Significantly reduces cell viability in parental MDA-MB-231 cells, with an IC50 value of 109 μg/mL.
- Reduces sphere formation and vimentin expression on CSCs in breast cancer.
- Significantly suppresses cell proliferation in CSC-enriched MDA-MB-231 cells.
- Significantly reduces ALDH1A1 expression by 50% in CSC-enriched MDA-MB-231 cells.
- Significantly increases the expressions of caspase 3, likely sensitizing CSC-enriched MDAMB-231 cells to apoptosis.
Medchemexpress LLC Acridone | 578-95-0 | 195.22 | 50 G
Acridone is an organic compound based on the acridine skeleton, recognized for its antibacterial, antimalarial, antiviral, and antineoplastic activities. This light yellow to green yellow solid is intended for research use only and inhibits the proliferation of MDA-MB-231 cancer cells, while also blocking the mRNA and protein expression of ATP binding cassette subfamily G member 2 (ABCG2).
- Organic compound based on acridine skeleton
- Possesses antibacterial activity
- Exhibits antimalarial activity
- Demonstrates antiviral activity
- Shows antineoplastic activities
- Inhibits proliferation of cancer cell MDA-MB-231
- Blocks mRNA and protein expression of ABCG2
- Appears as a light yellow to green yellow solid
Medchemexpress LLC 4-Bromophenylacetylene | 766-96-1 | 181.03 | 5 G
1-Bromo-4-ethynylbenzene is a biochemical reagent suitable for life science-related research as a biological material or organic compound. It functions as a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. This compound is also used as a starting material for second-order nonlinear optical materials, heterocyclotriynes, and unsymmetrical 1,4-diarylbutadiynes. It is intended for research use only and not sold to patients.
- Biochemical reagent for life science research
- Functions as a click chemistry reagent
- Contains an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Starting material for second-order nonlinear optical materials
- Starting material for heterocyclotriynes and unsymmetrical 1,4-diarylbutadiynes