Pyridines and derivatives
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- (1)
- (1)
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- (1)
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Filtered Search Results
Medchemexpress LLC Budesonide (22R)-enantiomer | 51372-29-3 | MFCD00870255 | 98.0% | 430.53 g/mol | C25H34O6 | 1MG
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(22R)-Budesonide is the (22R)-enantiomer of budesonide, a non-halogenated glucocorticoid with high local anti-inflammatory activity. It is supplied for research use to study glucocorticoid receptor interactions and stereochemistry-dependent pharmacology.
- Chemical formula: C25H34O6.
- Molecular weight: 430.53 g/mol.
- CAS number: 51372-29-3.
- Typical reported purity: 98.0%.
- Intended for research use only.
- Consult the certificate of analysis for storage and detailed purity data.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC 8-aminoadenosine | 3868-33-5 | MFCD00047230 | 99.9% | 282.26 | C10H14N6O4 | 50MG
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8-Aminoadenosine is an RNA-directed nucleoside analogue used in cellular and biochemical research. It reduces cellular ATP levels, inhibits mRNA synthesis, and interferes with signaling pathways to induce autophagy and apoptosis, making it useful for studies of transcriptional inhibition, energy metabolism, and anticancer mechanisms.
- Reduces cellular ATP levels and inhibits mRNA synthesis.
- Blocks Akt/mTOR signaling and induces autophagy and apoptosis.
- High purity (≈99.9%).
- Soluble in DMSO (≈83.3 mg/mL); may require sonication.
- Available in small research sizes (5-200 mg).
- Storage: powder -20°C (long term); in solution -80°C (short term).
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Bisphenol A bissulfate disodium | 10040-44-5 | MFCD22989096 | >95.0% | 432.38 | C15H14Na2O8S2 | 25 MG
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Bisphenol A bissulfate disodium is the disodium salt metabolite of Bisphenol A supplied for research use. It is reported to exhibit complement-inhibiting activity (IC50 = 247 μM) and is typically used in in vitro biochemical assays and as a reference standard. The material is a white solid with molecular formula C15H14Na2O8S2 and molecular weight 432.38.
- Reported complement-inhibiting activity (IC50 247 μM).
- Molecular formula C15H14Na2O8S2; molecular weight 432.38.
- Provided as a white solid; typical package 25 MG.
- Purity >95% by HPLC as reported in standards documentation.
- Suitable for in vitro biochemical assays and reference analyses.
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Apexbio Technology LLC PD-1/PD-L1 inhibitor 2(Synonyms: BMS-202, BMS202, PD-L1 inhibitor BMS-202, PD-1/PD-L1 antagonist BMS-202), 5mg, CAS: 1675203-84-5.
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PD-1/PD-L1 inhibitor 2 (CAS 1675203-84-5) also known as BMS-202 is a small molecule inhibitor targeting the PD-1/PD-L1 immune checkpoint interaction It binds directly to human PD-L1 protein disrupting its interaction with PD-1 receptor displaying an IC50 of 18 nM and a binding dissociation constant (KD) of approximately 8 M By obstructing the PD-1/PD-L1 signaling axis this compound is valuable in studies investigating tumor-associated immune modulation and understanding PD-L1 s biological function within the tumor immune microenvironment
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Medchemexpress LLC Licogliflozin | 1291094-73-9 | 98.0% | 416.46 | 1 ML
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Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor. It is also described as a non-anti-fibrotic treatment agent for non-alcoholic steatohepatitis (NASH).
- Sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor.
- Non-anti-fibrotic treatment agent for non-alcoholic steatohepatitis (NASH).
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Medchemexpress LLC Ninerafaxstat | 2254741-41-6 | 99.1% | 415.48 | 100 MG
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Ninerafaxstat is a novel orally active cardiac mitochondrial drug engineered to restore myocardial energy homeostasis. It functions by competitively inhibiting 3-ketoacyl-CoA thiolase (3-KAT), which partially suppresses fatty acid oxidation and redirects cardiac energy metabolism from fatty acid oxidation to glucose oxidation. This mechanism regulates myocardial substrate utilization, leading to improved cardiac efficiency and making it suitable for cardiovascular disease research.
- Restores myocardial energy homeostasis
- Competitively inhibits 3-ketoacyl-CoA thiolase (3-KAT)
- Partially suppresses fatty acid oxidation
- Shifts cardiac energy metabolism to glucose oxidation
- Regulates myocardial substrate utilization
- Improves cardiac efficiency
- Useful for research on cardiovascular diseases
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Medchemexpress LLC JCN037 (JGK037) | 2305154-31-6 | 99.1% | 376.18 | 1 ML
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JCN037 (JGK037) is a non-covalent and BBB-penetrant EGFR tyrosine kinase inhibitor, with IC50 values of 2.49 nM, 3.95 nM, and 4.48 nM for EGFR, p-wtEGFR, and pEGFRvⅢ, respectively. It exhibits GI50 values of 329 nM in HK301 cells and 1116 nM in GBM39 cells. In vivo, it downregulates pEGFRvⅢ, p Akt, p-ERK, and p-S6 protein levels and provides a significant survival benefit, increasing median survival by 47% from 37.5 days to 55 days.
- Non-covalent EGFR tyrosine kinase inhibitor.
- BBB-penetrant.
- Inhibits EGFR (IC50: 2.49 nM).
- Effective in HK301 (GI50: 329 nM) and GBM39 (GI50: 1116 nM) cells.
- Downregulates key protein phosphorylation.
- Increases median survival by 47% in vivo.
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Medchemexpress LLC 4-Isopropylcatechol | 2138-43-4 | 98.0% | 152.19 | 50 MG
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4-Isopropylcatechol is a potent and irreversible cutaneous depigmenting agent that significantly inhibits protein biosynthesis in mouse melanoma cells containing high levels of tyrosinase. It can be used to study hyperpigmentation of skins.
- Potent and irreversible cutaneous depigmenting agent
- Inhibits protein biosynthesis in mouse melanoma cells
- Useful for studying hyperpigmentation of skins
- Purity of 98.0%
- Molecular formula C9H12O2
- Appearance as an off-white to light yellow solid
- Storage at 4°C under nitrogen
- In solvent storage at -80°C for 6 months, or -20°C for 1 month, under nitrogen
- Not classified as a hazardous substance or mixture
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Medchemexpress LLC PD 90780 | 77422-99-2 | 98.8% | 362.34 | 10 MM x 1 ML
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PD 90780 is a non-peptide antagonist of nerve growth factor (NGF). It interacts with NGF, preventing NGF from binding with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 μM in PC12 cells and 1.8 μM in PC12nnr5 cells.
- Affects 125I-BDNF binding to truncated p75NTR at concentrations of 0.1-100 μM over 2 hours.
- Inhibits 125I-NGF cross-linking to p75NTR.
- Decreases TrkA phosphorylation resulting from NGF binding at a dose of 300 μM.
- Inhibits NGF-p75NTR interaction with IC50 values of 23.1 μM and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
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Selleck Chemical LLC CAY10566-E1227-1G
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CAY10566 is a potent orally bioavailable and selective inhibitor of stearoyl-CoA desaturase1 (SCD1) with IC50 of 4 5 and 26 nM in mouse and human enzymatic assays respectively It also demonstrates excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells
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Medchemexpress LLC Apararenone (MT-3995) | 945966-46-1 | 99.1% | 364.39 | 100 MG
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Apararenone is a novel non-steroidal mineralocorticoid receptor antagonist designed for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis. This compound is provided as a white to off-white solid.
- Acts as a mineralocorticoid receptor antagonist
- Developed for diabetic nephropathies and non-alcoholic steatohepatitis
- Ships at room temperature
- Store powder at -20°C for up to 3 years or 4°C for up to 2 years
- Store in solvent at -80°C for up to 2 years or -20°C for up to 1 year
- Soluble in DMSO at concentrations ≥ 125 mg/mL
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Apexbio Technology LLC Cyclosporin H 83602-39-5 1mg
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Cyclosporin H (CAS 83602-39-5) is a potent selective and competitive antagonist of the formyl peptide receptor (FPR) a G protein-coupled receptor involved in chemotaxis and immune cell responses to infection In human neutrophils Cyclosporin H inhibits FMLP-induced superoxide (O2-) generation with an IC50 of 0 7 M and blocks FMLP binding to cell membranes (IC50 0 7 M Ki 0 10 M) It also inhibits FMLP-stimulated GTP hydrolysis intracellular Ca2 increase O2- production and -glucuronidase release in a concentration-dependent manner In basophils Cyclosporin H competitively suppresses FMLP-induced leukotriene C4 and histamine release Additionally it promotes apoptosis in mouse bronchial eosinophils when co-administered with interleukin-5 or GM-CSF Cyclosporin H is valuable for studies investigating FPR-mediated cellular processes and inflammatory mechanisms
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Apexbio Technology LLC VRT-1353385 1616113-45-1 5mg
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VRT-1353385 (CAS 1616113-45-1) is a small-molecule antagonist targeting the chemokine receptor CCR9 It is designed to inhibit CCR9 thereby modulating immune cell homing to the intestinal mucosa and regulating lymphocyte migration and accumulation within gut tissue VRT-1353385 exerts its biological activity primarily through selective CCR9 antagonism In cell-based studies VRT-1353385 demonstrates inhibition of CCR9-mediated cell migration with an IC50 value of approximately 5 9 nM Based on these pharmacological properties VRT-1353385 holds research potential in the prevention of recurrence of postoperative Crohn s Disease
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Medchemexpress LLC G-CSF Mouse CHO 500ug
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Recombinant mouse granulocyte colony-stimulating factor (G-CSF) produced in CHO cells, provided for research applications to regulate neutrophil production, differentiation, and function. Commonly used in studies of hematopoiesis, inflammation, and immune response, the product is supplied in a laboratory-scale pack suitable for assay development and experimental workflows.
- Recombinant protein expressed in CHO cells for mammalian-like post-translational modifications.
- Regulates neutrophil proliferation and differentiation for hematopoietic studies.
- Suitable for in vitro and in vivo research applications.
- Provided in a laboratory-scale pack size for experimental use.
- Compatible with standard cell culture and biochemical assays.
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Medchemexpress LLC (3-Methyloxiran-2-yl)methanol | 872-38-8 | MFCD00033455 | 95.0% | 88.11 g/mol | C4H8O2 | 500 MG
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(3-Methyloxiran-2-yl)methanol is an epoxide-containing small molecule used primarily as a drug intermediate and reference compound in medicinal chemistry and organic synthesis. It is a low-molecular-weight, polar epoxide alcohol employed to introduce a 2,3-epoxybutanol fragment into target molecules and for ring-opening transformations.
- Epoxide alcohol functional group for ring-opening chemistry.
- Useful building block for medicinal chemistry and synthesis of active compounds.
- Reported purity approximately 95% (supplier specification).
- Molecular weight 88.11 g/mol and formula C4H8O2.
- Available in small research-scale pack sizes suitable for lab use.
- Provided with SDS, datasheet, and COA documentation for handling and verification.
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