Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,721 – 6,735 of 60,541 results

6,721

Cayman Chemical 1O14, Purity: ≥95%, CAS: 3117189-57-5, 25 mg

An ionizable cationic lipid; has been used in combination with other lipids in the formation of LNPs; 1O14-containing LNPs have been used for the delivery of IL-1β siRNA to induce gene silencing and hepatoprotective effects in a mouse model of acute liver injury

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6,722

Cayman Chemical Erinacine A, Purity: ≥98%, CAS: 156101-08-5, 5 mg

A diterpenoid with anticancer and neuroprotective activities; decreases the viability of, and induces cell cycle arrest at the G1 phase and ROS production in, DLD-1 cells at 10 µM; increases the production of NGF in mouse astroglial cells at 1 mM; increases the time spent on the rod in a rotarod test in a mouse model of MPTP-induced Parkinson’s disease at 1 mg/kg, i.p.; oral administration decreases infarct volume in a mouse model of ischemic brain injury induced by transient right common carotid artery occlusion at 4 mg/kg

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6,723

Active Motif Embelin

Active Motif's Embelin inhibits the lysine acetyltransferase PCAF in vitro and in vivo (in vitro IC50 = 7.2 uM). It inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, and H4K12 unchanged. It also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 uM, competing with Smac peptide). Embelin to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. It induces apoptosis and alters gene expression profiles in breast cancer cells. Embelin possesses anti-inflammatory and analgesic activity in vivo, and it is cell permeable.

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6,724

Medchemexpress LLC HY-116677 50mg Medchemexpress, Tris(benzyltriazolylmethyl)amine CAS:510758-28-8 Purity:>98%

Medchemexpress, HY-116677 50mg Tris(benzyltriazolylmethyl)amine CAS:510758-28-8 Tris(benzyltriazolylmethyl)amine (TBTA) is a ligand that acts as a biochemical tool for the tagging of proteins and enzymes. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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6,725

Cayman Chemical CAY10788, Purity: ≥95%, CAS: 119515-00-3, 5 mg

A CysLT1 receptor antagonist (IC50 = 3.9 µM)

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6,726

Cayman Chemical RU-521, Purity: ≥98%, CAS: 2262452-06-0, 1 mg

A cGAS inhibitor (IC50 = 0.11 µM); inhibits dsDNA-induced IFN-β1-dependent gene expression in a reporter assay; reduces basal Ifnb1 mRNA expression in BMDMs generated from the Trex1-/- mouse model of Aicardi-Goutières syndrome

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6,727

Medchemexpress LLC (2S)-1-[(tert-butoxy)carbonyl]-2-methylazetidine-2-carboxylic acid | 1363402-35-0 | MFCD22395149 | 97.1% | 215.25 g/mol | C10H17NO4 | 100 MG

(2S)-1-[(tert-butoxy)carbonyl]-2-methylazetidine-2-carboxylic acid is a Boc-protected azetidine carboxylic acid used as a drug intermediate in medicinal chemistry and organic synthesis. It is intended for research and synthetic applications, and is supplied with analytical data supporting its stated purity.

Purity: 97.1%.
Molecular weight: 215.25 g/mol.
Chemical formula: C10H17NO4.
CAS number: 1363402-35-0.
Available in small-scale packaging for research use (100 mg-10 g).
Function: synthetic building block and intermediate for substituted azetidine compounds.

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6,728

Cayman Chemical CU-CPT8m, Purity: ≥98%, CAS: 125079-83-6, 10 mg

An antagonist of TLR8 (Kd = 220 nM; IC50 = 67 nM in a reporter assay); is selective for TLR8 over a panel of all other human TLRs at 1 μM; inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells at 1 μM; inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human PBMCs in a concentration-dependent manner; decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.

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6,729

Cayman Chemical BLT-1, Purity: ≥98%, CAS: 321673-30-7, 25 mg

An inhibitor of SR-BI; It inhibits uptake of [3H]cholesteryl ester-HDL in ldlA[mSR-BI] cells (IC50 = 0.11 µM; inhibits the efflux of cholesterol from ldlA[mSR-BI] cells to HDL (IC50 = 0.15 µM); induces developmental defects in zebrafish embryos at 8 µM

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6,730

Selleck Chemical LLC Methylene Blue trihydrate E4805-1G

Methylene blue trihydrate (C I Basic Blue 9 trihydrate) acts as an inhibitor of soluble guanylyl cyclase (sGC) monoamine oxidase A (MAO-A) and NO synthase (NOS) Methylene blue trihydrate exhibits antimalarial antidepressant and anxiolytic activity effects Methylene Blue trihydrate has potential applications in treating methemoglobinemia neurodegenerative disorders and ifosfamide-induced encephalopathy

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6,731

Medchemexpress LLC HY-N0757 5mg Medchemexpress, 8-O-Acetylharpagide CAS:6926-14-3 Purity:>98%

Medchemexpress, HY-N0757 5mg 8-O-Acetylharpagide CAS:6926-14-3 8-O-Acetylharpagide is an iridoid isolated from Ajuga reptans with antitumoral, antiviral, antibacterial, and anti-inflammatory activities. 8-O-Acetylharpagide also has a biological activity on isolated smooth muscle preparations from guinea pig. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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6,732

Medchemexpress LLC BCN-endo-PEG4-NHS 50mg

BCN-endo-PEG4-NHS is an ADC Linker containing 4 PEG units BCN-endo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand endo-BCN which allows for further synthesis of macrocyclic complexes In click chemistry endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts

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6,733

Medchemexpress LLC KRAS G12D inhibitor 14 | 2765254-39-3 | 98.9% | 420.45 g·mol⁻¹ | C20H19F3N4OS | 5 MG

KRAS G12D inhibitor 14 is a small-molecule research inhibitor that selectively targets the KRAS G12D mutant. It binds KRAS G12D with a reported Kd of 33 nM, shows antiproliferative activity (IC50 = 2.1 μM) in KRAS G12D-mutant cell lines, and reduces KRAS G12D-GTP levels and downstream Raf/ERK signaling. In vivo studies report antitumor efficacy without apparent toxicity.

Selective binder of KRAS G12D (Kd = 33 nM).
Antiproliferative activity in KRAS G12D cell lines (IC50 = 2.1 μM).
Reduces KRAS G12D-GTP and down-regulates phosphorylated Raf and Erk.
Induces apoptosis in responsive cancer cell lines.
Available as solid and as a 10 mM solution in DMSO for research use.

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6,734

Apexbio Technology LLC Methazolamide, 50mg. Cas: 554-57-4 MFCD: MFCD00083416. Carbonic anhydrase inhibitor

Methazolamide, a derivative of sulfonamide, is an inhibitor of carbonic anhydrase (CA) that potently inhibits isoenzymes of CA, CA II and CA IV with values of 50% inhibition concentration IC50 of 8.1 nM and 80.3 nM respectively. Other sizes are available. Please inqury us for quote.

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6,735

TARGETMOL CHEMICALS INC BMS-929075 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity. purity: 97%

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Medchemexpress LLC HY-116677 50mg Medchemexpress, Tris(benzyltriazolylmethyl)amine CAS:510758-28-8 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (2S)-1-[(tert-butoxy)carbonyl]-2-methylazetidine-2-carboxylic acid | 1363402-35-0 | MFCD22395149 | 97.1% | 215.25 g/mol | C10H17NO4 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-N0757 5mg Medchemexpress, 8-​O-​Acetylharpagide CAS:6926-14-3 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BCN-endo-PEG4-NHS 50mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC KRAS G12D inhibitor 14 | 2765254-39-3 | 98.9% | 420.45 g·mol⁻¹ | C20H19F3N4OS | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-116677 50mg Medchemexpress, Tris(benzyltriazolylmethyl)amine CAS:510758-28-8 Purity:>98%

Medchemexpress LLC (2S)-1-[(tert-butoxy)carbonyl]-2-methylazetidine-2-carboxylic acid | 1363402-35-0 | MFCD22395149 | 97.1% | 215.25 g/mol | C10H17NO4 | 100 MG

Medchemexpress LLC HY-N0757 5mg Medchemexpress, 8-O-Acetylharpagide CAS:6926-14-3 Purity:>98%

Medchemexpress LLC BCN-endo-PEG4-NHS 50mg

Medchemexpress LLC KRAS G12D inhibitor 14 | 2765254-39-3 | 98.9% | 420.45 g·mol⁻¹ | C20H19F3N4OS | 5 MG