Bioactive Small Molecules
Cayman Chemical Obeldesivir, Purity: ≥98%, CAS: 2647441-36-7, 5 mg
An antiviral nucleoside analog and a prodrug form of GS-441524; inhibits the replication of SARS-CoV-2 and SARS-CoV-2 Βeta, Gamma, or Omicron variants in infected Vero E6 cells (EC50s = 1.36, 1.127, 0.349, and 0.106 µM, respectively) without inducing cytotoxicity (CC50 = 128 µM); reduces nucleocapsid gRNA copy number and nucleocapsid sgRNA levels in the lungs of, and decreases lung damage in, a KI-hACE2 mouse model of SARS-CoV-2 infection at 250 or 500 mg/kg per day; reduces the levels of S protein in the lungs of, as well as decreases PFUs in lung tissues, reduces lung and spleen inflammation, and prevents viral infection-induced death in, a K18-hACE2 mouse model of SARS-CoV-2 infection at 100 or 250 mg/kg per day
Cayman Chemical BAY-1816032, Purity: ≥98%, CAS: 1891087-61-8, 25 mg
An inhibitor of BUB1 kinase (IC50 = 6.1 nM); selective for BUB1 over FLT3 (IC50 = 4.2 µM) and 15 other kinases (IC50s = >10 µM for all); inhibits proliferation of a variety of cancer cells (median IC50 = 1.4 µM); reduces tumor growth in a SUM149 mouse xenograft model at 25 mg/kg
Cayman Chemical Propafenone-d5 (hydrochloride), Purity: ≥99% deuterated forms (d1-d5), CAS: 1346605-05-7, 5 mg
An internal standard for the quantification of propafenone by GC- or LC-MS
Medchemexpress LLC 1-Propanesulfonic acid, 3-(cyclohexylamino)-2-hydroxy- | 73463-39-5 | 98.0% | 25 G
CAPSO is a biological zwitterionic buffer with a useful pH range from 8.9 to 10.3. It is intended for research use only.
- Molecular weight: 237.32
- Formula: C9H19NO4S
- Appearance: solid
- Color: white to off-white
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
- Solubility: DMSO: 25 mg/mL (105.34 mM)
Cayman Chemical BTB-1, Purity: ≥98%, CAS: 86030-08-2, 250 mg
A reversible Kif18A inhibitor (IC50 = 1.69 μM); selective for Kif18A over a panel of seven kinesins at 100 μM; inhibits Kif18A-dependent microtubule motility in a microtubule gliding assay at 100 μM; induces mitotic accumulation of HeLa cells
Medchemexpress LLC O-linked GlcNAc transferase substrate | 954381-93-2 | 98.3% | 1783.08 | 1 MG
O-Linked GlcNAc transferase substrate is a biologically active peptide that functions as a substrate for O-linked GlcNAc transferase (OGT). OGT is a eukaryotic glycosyltransferase that utilizes UDP-GlcNAc as a glycosyl donor. This product is intended for research use only.
- Biologically active peptide
- Functions as a substrate for OGT
- Utilizes UDP-GlcNAc as a glycosyl donor
- Suitable for research applications
Cayman Chemical α-Piperidinobutiophenone (hydrochloride), Purity: ≥98%, CAS: 92728-82-0, 5 mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Medchemexpress LLC CDCP1 Mouse Biotin 50ug | 50ug
The CDCP1 protein has been implicated in cell adhesion and matrix association suggesting a role in important cellular interactions Its phosphorylation suggests a dynamic function in regulating anchorage migration proliferation or differentiation CDCP1 Protein Mouse (Biotinylated HEK293 His-Avi) is the recombinant mouse-derived CDCP1 protein expressed by HEK293 with C-Avi C-His labeled tag
Medchemexpress LLC 12-dipalmitoyl-sn-glycero-3-ps-d62 sodium | 327178-94-9 | MFCD00674412 | 99.0% | 820.33 | C38H11D62NNaO10P | 5 MG
12-Dipalmitoyl-sn-glycero-3-PS-d62 sodium is a deuterium-labeled phosphatidylserine (sodium salt) provided as a stable isotope standard for analytical and lipid research. It is designed for use in mass spectrometry, lipidomics, membrane studies, and method development where isotopic labeling or internal standards are required.
- Deuterium-labeled (d62) for accurate mass spectrometry quantitation.
- High purity (99.0%) suitable for analytical workflows.
- Sodium salt form compatible with common lipid extraction and reconstitution protocols.
- Supplied in milligram quantities for isotopic standards and tracer experiments.
- Useful for lipidomics, membrane biophysics, and method development applications.
Medchemexpress LLC Tetrahydrouridine dihydrate | C9H20N2O8 | 1 ML
Tetrahydrouridine dihydrate (THU dihydrate) is a potent inhibitor of cytidine deaminase (CDA), effectively blocking the enzyme's active site more effectively than intrinsic cytidine. This compound is intended for research use only.
- Potent inhibitor of cytidine deaminase (CDA)
- Competitively blocks the enzyme's active site
- More effective than intrinsic cytidine
- Suppresses deamination in the catabolism of cytotoxic deoxycytidine analogues
- Sensitizes some pancreatic and lung carcinoma cells to gemcitabine
- Inhibits S-phase without inducing apoptosis
Cayman Chemical Coumarin 343, Purity: ≥95%, CAS: 55804-65-4, 250 mg
A coumarin laser dye; abs/em = 446/519 nm
Medchemexpress LLC 2,5-Dihydroxybenzoic acid | 490-79-9 | 154.12 | 1 ML
2,5-Dihydroxybenzoic acid is an analytical standard and a derivative of benzoic acid, intended for research and analytical applications. This compound acts as a powerful inhibitor of fibroblast growth factors, a reactive oxygen species (ROS) scavenger, and an antioxidant. It has demonstrated anti-proliferative activity in human breast cancer cells and inhibits tumor growth in mice with advanced gastric cancer.
- Analytical standard for research and analytical applications
- Derivative of benzoic acid
- Powerful inhibitor of fibroblast growth factors
- Reactive oxygen species (ROS) scavenger
- Antioxidant, protecting cells against oxidative damage
- Exhibits anti-proliferative activity in human breast cancer cells
- Inhibits tumor growth in mice with advanced gastric cancer
Apexbio Technology LLC PPT 263717-53-9 10mg
PPT (263717-53-9) is a small-molecule agonist targeting estrogen receptor (ER ) It is designed to selectively activate ER thereby modulating estrogen-mediated signaling pathways PPT exerts its biological activity primarily through receptor subtype-specific agonism displaying a relative binding affinity for ER (49%) that is 410-fold higher than for estrogen receptor (ER 0 12%) Based on these pharmacological properties PPT holds research potential in studying ER -mediated cellular responses gene expression changes and investigating estrogen-related mechanisms including receptor-specific cell proliferation differentiation and physiological processes regulated through the ER signaling axis
Selleck Chemical LLC SRX3177 E4702-1G
SRX3177 is a potent triple inhibitor targeting CDK4/6 PI3K and BRD4 with IC50 values of 33 nM for BRD4 BD1 89 nM for BRD4 BD2 79 nM for PI3K 83 nM for PI3K 3 18 M for PI3K 2 5 nM for CDK4 and 3 3 nM for CDK6 By simultaneously inhibiting these key pathways SRX3177 disrupts cancer cell signalling and exhibits significant cytotoxic effects in tumors
Medchemexpress LLC Benzylideneacetone | 122-57-6 | 99.7% | 146.19 | 50 G
Benzylideneacetone is an orally active antibiotic, tyrosinase inhibitor, phospholipase A2 inhibitor, and immunosuppressant. It exhibits antibacterial activity against certain gram-negative plant-pathogenic bacteria and can be used in the synthesis of chemicals and drugs, as well as a flavoring additive for some foods.
- Orally active antibiotic
- Tyrosinase inhibitor
- Phospholipase A2 inhibitor
- Immunosuppressant
- Antibacterial activity against gram-negative plant-pathogenic bacteria
- Used in synthesis of chemicals and drugs
- Functions as a flavoring additive