Dimethyl Sulfoxide
Medchemexpress LLC SJ6986, Solution 10 mM * 1 mL in DMSO | CAS No. : 2765625-93-0
SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1.
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 200L
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 200L
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 |
Dimethyl sulfoxide | 67-68-5 | MFCD00002089 |
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology, 67-68-5, MFCD00002089, 250mL
Linear Formula (CH3)2SO, Molecular Weight 78.13, for molecular biology, Synonym: DMSO
Selleck Chemical LLC OSS_128167, 10mM (1mL in DMSO)
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
Apexbio Technology LLC Pexidartinib (PLX3397) 1029044-16-3 10mM (in 1mL DMSO)
Pexidartinib (PLX3397 CAS 1029044-16-3) is a small molecule inhibitor targeting colony-stimulating factor 1 receptor (CSF-1R) a receptor tyrosine kinase involved in macrophage recruitment and activation Through inhibition of CSF-1R activity this compound reduces macrophage infiltration and accumulation demonstrated by diminished macrophage levels in B16F10 melanoma models without affecting Gr-1 myeloid-derived suppressor cells In vivo studies using GL261 glioma models in C57 mice indicate decreased microglial infiltration upon oral dosing with PLX3397 Clinically combined treatment with Pexidartinib and paclitaxel is under evaluation in advanced solid tumors and breast cancer trials
Apexbio Technology LLC Ezatiostat hydrochloride 286942-97-0 10mM (in 1mL DMSO)
Ezatiostat hydrochloride (CAS 286942-97-0) also known as TLK199 is a small-molecule inhibitor primarily targeting glutathione S-transferase (GST) specifically the GST P1-1 isoform GST P1-1 typically suppresses the Jun N-terminal kinase (JNK) signaling pathway thus Ezatiostat hydrochloride through GST P1-1 inhibition activates JNK signaling In preclinical research this activation has been associated with increased proliferation maturation and differentiation of hematopoietic precursor cells Additionally Ezatiostat hydrochloride induces growth arrest and apoptosis in human leukemia HL-60 cells (CC50 approximately 6-17 M) It holds potential for treating cytopenias and hematological disorders
Apexbio Technology LLC PD 151746 179461-52-0 10mM (in 1mL DMSO)
PD 151746 is a cell-permeable inhibitor that selectively targets calpain a calcium-dependent cysteine protease involved in various cellular processes With a Ki value of 0 26 M against -calpain it prevents the proteolytic cleavage of substrates like neuronal nitric oxide synthase (nNOS) and calmodulin-dependent protein kinase II-alpha (CaMPK-II) particularly under stress In neuronal models PD 151746 inhibits apoptosis induced by serum/potassium withdrawal reduces MEF2 phosphorylation suppresses cdk5/p25 complex formation and decreases caspase-3 activation In HepG2 hepatoma cells it disrupts insulin-stimulated glycogen synthesis and affects protein tyrosine phosphatase-2 (PTP2) expression PD 151746 is used in research to study calpain-related signaling pathways apoptosis cell motility and metabolism
Apexbio Technology LLC Preladenant 377727-87-2 10mM (in 1mL DMSO)
Preladenant is a potent and selective antagonist targeting the adenosine A2A receptor (Ki 1 1 nM) developed from structural modifications of SCH 58261 Structurally it is a methoxy derivative carrying enhanced affinity and selectivity towards human and rat A2A receptors over A1 A2B and A3 subtypes Mechanistically Preladenant competitively blocks A2A receptor-mediated adenylate cyclase activation In preclinical studies Preladenant reduces Parkinsonian symptoms in primate and rodent models alone or in combination with L-Dopa thus widely employed in experimental research for Parkinson s disease and associated movement disorders
Apexbio Technology LLC Topotecan 123948-87-8 10mM (in 1mL DMSO)
Topotecan (CAS 123948-87-8) a semisynthetic derivative of camptothecin functions by selectively inhibiting topoisomerase I This inhibition stabilizes enzyme-DNA cleavage complexes disrupting DNA replication and transcription processes essential for tumor cell proliferation In preclinical studies topotecan demonstrated antitumor activity in mouse models of leukemia (P388) Lewis lung carcinoma B16 melanoma and human colon adenocarcinoma xenograft HT-29 Its toxicity primarily affecting rapidly proliferating tissues such as bone marrow and gastrointestinal epithelium was concentration-dependent and reversible Topotecan is employed extensively as a research tool in oncology studies focusing on DNA-topoisomerase interactions and targeting solid tumor growth
Apexbio Technology LLC Kinetin 525-79-1 10mM (in 1mL DMSO)
Kinetin (N6-furfuryladenine) is a natural adenine derivative classified as a cytokinin originating from plant tissues and participates in diverse physiological processes including cell division and cellular differentiation Structurally kinetin contains an adenine core with a furfuryl substituent at position N6 Experimentally kinetin induces apoptosis-like morphological changes nuclear fragmentation and hypoploidy in vitro in various cell types Additionally kinetin contributes to modulation of RNA splicing patterns notably demonstrated through the promotion of exon 20 inclusion in familial dysautonomia models Due to these properties kinetin serves as an investigational tool in studies of RNA processing apoptosis mechanisms and is examined as a potential therapeutic agent in splicing-associated diseases
Apexbio Technology LLC AEBSF.HCl 30827-99-7 10mM (in 1mL DMSO)
AEBSF HCl is an irreversible serine protease inhibitor that covalently binds and inhibits several proteases including trypsin chymotrypsin plasmin and thrombin It has been applied in cellular research to study amyloid-beta (A ) production mechanisms In APP695 (K695sw)-transfected K293 cells AEBSF dose-dependently reduces A formation with an IC50 around 1 mM while in wild-type APP695-transfected HS695 and SKN695 cells it shows inhibitory effects with an IC50 of approximately 300 M Besides suppressing -cleavage AEBSF promotes -cleavage of APP In macrophage-mediated leukemic cell lysis assays incubation with AEBSF at 150 M for 6 hours achieves near-maximal protease inhibition thus impeding cell lysis
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 500 mL
Dimethyl sulfoxide | Purity: ≥99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500 mL