Dimethyl Sulfoxide
Apexbio Technology LLC Nanaomycin A 52934-83-5 10mM (in 1mL DMSO)
Nanaomycin A is a selective inhibitor targeting DNA methyltransferase 3B (DNMT3B) with an IC50 of approximately 500 nM It acts by specifically inhibiting DNMT3B-mediated DNA methylation without notably affecting DNMT1 activity In cell-based studies employing cancer cell lines such as HCT116 A549 and HL60 treatment with Nanaomycin A reduced global DNA methylation levels and reactivated transcription of tumor suppressor genes previously silenced via promoter hypermethylation Its use in epigenetics-related research includes quantitative assessment of DNMT3B function investigation of DNA methylation regulation mechanisms and evaluation of gene reactivation consequent to DNMT3B inhibition
Apexbio Technology LLC CCT128930 HCl 885499-61-6 (free base) 10mM (in 1mL DMSO)
CCT128930 HCl is a potent selective ATP-competitive inhibitor targeting AKT2 kinase with an IC50 of approximately 6 nM It exhibits higher selectivity for AKT2 compared to related kinases such as PKA and p70S6K Akt protein kinase involved in diverse cellular pathways including metabolism proliferation apoptosis transcription control and cell mobility is frequently deregulated in various tumor types In cancer cell models CCT128930 HCl impairs cellular proliferation and reduces phosphorylation of specific Akt downstream substrates Preclinical studies employing PTEN-deficient glioma cells and breast cancer xenograft models show inhibition of signaling activity and tumor growth Consequently CCT128930 HCl serves as a promising research tool for studying Akt-mediated signaling mechanisms pathway regulation and potential therapeutic responses in cancer biology
Apexbio Technology LLC SCR7 1533426-72-0 10mM (in 1mL DMSO)
SCR7 (CAS 1533426-72-0) is a small-molecule inhibitor targeting DNA ligase IV and to a lesser extent DNA ligase III It interacts with the DNA-binding domain of DNA ligase IV thereby diminishing its affinity for double-strand breaks (DSBs) and effectively blocking nonhomologous end-joining (NHEJ)-mediated DNA repair In cell culture models expressing inducible Cas9 SCR7-mediated transient inhibition of NHEJ promotes increased homologous-directed repair (HDR) by facilitating accumulation in the S/G2 phase SCR7 treatment in mice transiently impairs lymphocyte development due to the reversible inhibition of DNA ligase IV activity during V(D)J recombination Thus SCR7 serves as a useful tool in genome editing research to enhance precise gene editing efficiency
Apexbio Technology LLC 4μ8C 14003-96-4 10mM (in 1mL DMSO)
4 8C (CAS 14003-96-4) is a small molecule inhibitor targeting the RNase activity of inositol-requiring enzyme 1 alpha (IRE1 ) an important transmembrane serine/threonine kinase involved in the unfolded protein response (UPR) By selectively blocking IRE1-mediated RNase function 4 8C inhibits downstream UPR gene activation in cell lines exposed to hypoxia or endoplasmic reticulum (ER) stressors including HCT116 colon carcinoma and KP4 pancreatic cancer cells without affecting proliferation or clonogenic survival under these conditions Due to its selective action 4 8C serves as a valuable tool in research investigating ER stress pathways and their roles in cellular adaptation and disease pathology
Apexbio Technology LLC Dopamine HCl 62-31-7 10mM (in 1mL DMSO)
Dopamine HCl (CAS 62-31-7) is a catecholamine neurotransmitter that functions as an endogenous agonist at dopamine receptors (subtypes D1 D5) Mechanistically dopamine activates these G protein-coupled receptors modulating neurotransmission and influencing diverse physiological processes such as motor control cognition motivation and neuroendocrine regulation In biomedical research dopamine HCl serves as a standard reagent for investigating dopaminergic signaling pathways receptor pharmacology and the molecular basis of neurological disorders
Apexbio Technology LLC Ferrostatin-1 (Fer-1) 347174-05-4 10mM (in 1mL DMSO)
Ferrostatin-1 (Fer-1) is a selective inhibitor of ferroptosis a regulated form of iron-dependent oxidative cell death characterized by lipid peroxidation It functions primarily by reducing lipid reactive oxygen species (ROS) thus inhibiting membrane lipid peroxidation and preventing ferroptosis induction triggered by compounds such as erastin In experimental contexts Fer-1 is employed to investigate ferroptotic pathways in different disease models including cancer biology neurodegeneration and ischemic injury Ferrostatin-1 demonstrates an IC50 value of approximately 60 nM in inhibiting ferroptosis induced by erastin in cellular assays rendering it suitable for mechanistic studies and therapeutic research involving modulation of iron-dependent oxidative damage pathways
Apexbio Technology LLC Mitomycin C 10mM (in 1mL DMSO)
Mitomycin C (CAS 50-07-7) is an antibiotic compound derived from Streptomyces caespitosus or Streptomyces lavendulae exhibiting anti-cancer properties by interfering with DNA synthesis Its mode of action involves direct formation of covalent adducts with DNA impeding DNA replication In PC3 cells mitomycin C presents an EC50 of approximately 0 14 M Moreover it can potentiate apoptosis induced by TRAIL (TNF-related apoptosis-inducing ligand) through mechanisms independent of p53 modulating apoptosis-related protein expression and caspase activation Due to its cytotoxic mechanism mitomycin C continues to serve as a useful compound in cancer research particularly in apoptosis signaling studies
Apexbio Technology LLC Pirarubicin 72496-41-4 10mM (in 1mL DMSO)
Pirarubicin is a DNA intercalating anthracycline antibiotic structurally related to doxorubicin that targets the DNA topoisomerase II enzyme By stabilizing the cleavable DNA-enzyme complex pirarubicin induces DNA strand breaks and inhibits DNA replication and cellular proliferation Its primary mode of action involves disruptive interactions with topoisomerase II-mediated DNA cleavage and repair mechanisms Pirarubicin is utilized as an antineoplastic agent in oncology research particularly in evaluating its activity against diverse cancer cell lines In vitro studies reported IC50 values typically ranging from approximately 0 1 to several micromolar concentrations varying according to cell type and experimental conditions Therefore pirarubicin serves as a tool compound in pharmacological studies investigating DNA-topoisomerase inhibitors and therapeutic resistance mechanisms
Apexbio Technology LLC SAR245409 (XL765) 1349796-36-6 10mM (in 1mL DMSO)
SAR245409 (XL765 CAS 1349796-36-6) is a selective dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with high potency against PI3K (IC50 9 nM) It suppresses the PI3K/Akt/mTOR signaling cascade by preventing formation of phosphatidylinositol-3 4 5-triphosphate (PIP3) at the cell membrane and downstream phosphorylation of AKT p70S6 kinase and S6 SAR245409 demonstrates antitumor activity in cancer models exhibiting genetic alterations in PI3K pathways enhancing growth suppression and apoptosis It is commonly employed in preclinical studies evaluating PI3K/mTOR-targeted approaches in cancer therapy
Apexbio Technology LLC PF-4708671 1255517-76-0 10mM (in 1mL DMSO)
PF-4708671 (CAS 1255517-76-0) is a cell-permeable small molecule that specifically inhibits p70 ribosomal S6 kinase 1 (S6K1) S6K1 regulates diverse cellular processes including protein synthesis and insulin signaling pathways PF-4708671 inhibits S6K1 with an IC50 of 160 nM in HEK293 cell-derived enzyme assays and has a reported Ki value of 20 nM in vitro It selectively inhibits S6K1 over structurally related kinases such as RSK2 and MSK1 hindering phosphorylation of downstream substrates including ribosomal protein S6 mTOR and Rictor PF-4708671 is valuable in biomedical research involving cancer and insulin resistance
Apexbio Technology LLC Doxercalciferol 54573-75-0 10mM (in 1mL DMSO)
Doxercalciferol chemically known as 1 -Hydroxyvitamin D2 is a synthetic analog of vitamin D2 characterized by selective activation of the vitamin D receptor (VDR) Upon metabolic activation Doxercalciferol undergoes hepatic transformation to its biologically active form inducing gene transcription mediated via the VDR signaling pathway Central to its mechanism activated VDR regulates calcium and phosphate homeostasis influencing cellular differentiation proliferation and parathyroid hormone expression In biomedical research Doxercalciferol serves as a tool compound to investigate the molecular pathways regulated by vitamin D receptor activation particularly in renal insufficiency models bone metabolism studies and parathyroid physiology experiments
Apexbio Technology LLC Ronidazole 7681-76-7 10mM (in 1mL DMSO)
Ronidazole is a nitroimidazole compound exhibiting both antiprotozoal and antibacterial activities Its mechanism of action involves the generation of metabolites that interact with microbial DNA resulting in DNA damage and inhibition of nucleic acid synthesis Ronidazole is commonly employed in veterinary research settings to investigate therapeutic interventions against protozoan parasites such as Tritrichomonas foetus infections in feline models Histomonas meleagridis-mediated histomoniasis and Brachyspira hyodysenteriae-related swine dysentery It can be administered orally to experimental animal subjects for clarifying pathological mechanisms and therapeutic pathways in parasitic disease models Currently detailed IC50 data for Ronidazole remain underreported in literature
Apexbio Technology LLC Azaguanine-8 134-58-7 10mM (in 1mL DMSO)
Azaguanine-8 (CAS 134-58-7) is a synthetic purine analog utilized in biomedical research due to its antineoplastic properties Structurally similar to guanine Azaguanine-8 exerts its biological activity by competitively interfering with guanine metabolism subsequently disrupting nucleic acid synthesis and cellular replication pathways Through this mechanism the compound demonstrates inhibitory effects on cell proliferation making it a valuable tool in investigating nucleic acid metabolism and cancer biology in preclinical studies
Apexbio Technology LLC Penciclovir 39809-25-1 10mM (in 1mL DMSO)
Penciclovir is a selective inhibitor of herpes simplex virus 1 (HSV-1) DNA synthesis Structurally derived from guanine penciclovir undergoes phosphorylation within virus-infected cells forming penciclovir triphosphate the active antiviral metabolite Penciclovir triphosphate specifically targets viral DNA polymerase blocking HSV-1 DNA replication In vitro experiments using MRC-5 cells demonstrate inhibition of HSV-1 replication at an IC50 of 0 16 M without interfering with host cellular DNA synthesis This mechanism of action renders penciclovir suitable for antiviral research targeting HSV-1 replication as well as drug-resistance and mechanism-of-action studies involving HSV-2 and varicella-zoster virus (VZV)
Apexbio Technology LLC Carprofen 53716-49-7 10mM (in 1mL DMSO)
Carprofen (CAS 53716-49-7) is a non-steroidal anti-inflammatory drug (NSAID) primarily characterized by selective inhibition of cyclooxygenase-2 (COX-2) This selective targeting leads to decreased prostaglandin synthesis mitigating inflammation and pain responses In assays involving canine COX-2 enzyme carprofen exhibits inhibitory activity with an IC50 value of approximately 0 03 mM Due to its targeted COX-2 inhibition carprofen serves as a useful research compound in veterinary and biomedical studies investigating inflammatory pathways and analgesic mechanisms