Dimethyl Sulfoxide
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide anhydro1L
Dimethyl Sulfoxide is an apolar protic solvent that is generally used as a reaction medium and reagent in organic reactions.
Apexbio Technology LLC DMXAA (Vadimezan) 117570-53-3 10mM (in 1mL DMSO)
DMXAA (Vadimezan AS-1404) is a tumor vascular disrupting and apoptosis-inducing agent functioning primarily through inhibition of DT-diaphorase (DTD) It acts by suppressing DTD enzymatic activity showing an IC50 of approximately 62 5 M Additionally DMXAA inhibits various kinases notably VEGFR2 disrupting endothelial cells and blood vessel formation to induce tumor cell apoptosis and vascular necrosis Experimentally DMXAA demonstrates activity in murine tumor models including induction of apoptosis in endothelial cells and tumor vasculature promoting necrosis and tumor regression Therefore DMXAA is commonly used in oncology research focused on anti-angiogenesis and tumor vascular disruption mechanisms
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide suitabl
Dimethyl sulfoxide (DMSO) is a polar organic solvent. DMSO activated by various electrophiles (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. Due to its higher stability it has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction.
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 6 x 1 L
Dimethyl sulfoxide | Purity: ≥99.5% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 6 x 1 L
Medchemexpress LLC Encorafenib (Synonyms: LGX818) 10 mM * 1 mL in DMSO
Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).
Medchemexpress LLC Ro4929097 10 Mm / 1 Ml In Dmso | HY-11102-10MM/1ML IN DMSO
Ro4929097 10 Mm / 1 Ml In Dmso
Medchemexpress LLC Carbocysteine sulfoxide | 5439-87-2 | MFCD21364079 | 99.0% | 195.19 | C5H9NO5S | 25 MG
Carbocysteine sulfoxide is a small-molecule drug intermediate and a reported impurity of carbocisteine supplied for research and analytical use. It is intended for impurity profiling, method development, and related analytical applications. The compound is identified by CAS number 5439-87-2 and has formula C5H9NO5S and a molecular weight of 195.19 g/mol. Storage and handling recommendations are provided in the product certificate of analysis.
Apexbio Technology LLC Clofazimine 2030-63-9 10mM (in 1mL DMSO)
Clofazimine is a rhimophenazine compound with demonstrated antimicrobial and anti-inflammatory properties commonly utilized in biomedical research related to tuberculosis treatment and drug-resistance studies It functions primarily through the intercalation into bacterial DNA interfering with microbial DNA replication and transcription processes Furthermore it may induce bacterial phospholipid membrane disruption and modulate inflammatory responses Experimental studies report IC50 values in the micromolar range against Mycobacterium tuberculosis strains Clofazimine is frequently employed as a reference compound in antimicrobial assays mechanistic studies on DNA-targeting agents and evaluations of cellular inflammatory pathways within infectious disease model systems
Apexbio Technology LLC Atomoxetine HCl 82248-59-7 10mM (in 1mL DMSO)
Atomoxetine HCl (CAS 82248-59-7) is a selective inhibitor of the norepinephrine transporter (NET) a membrane protein responsible for norepinephrine reuptake and synaptic homeostasis Atomoxetine shows high selectivity towards human NET (Ki 5 nM) with substantially lower affinity for serotonin (Ki 77 nM) and dopamine transporters (Ki 1451 nM) In preclinical studies using rat models atomoxetine elevated extracellular norepinephrine and dopamine specifically in the prefrontal cortex region without affecting dopamine levels in the striatum or nucleus accumbens These traits render it useful in research on neurotransmitter regulation related to cognition and attention disorders
Apexbio Technology LLC Hydroxyurea 127-07-1 10mM (in 1mL DMSO)
Hydroxyurea is a potent inhibitor of ribonucleoside diphosphate reductase a rate-limiting enzyme converting ribonucleotides to deoxyribonucleotides thereby interrupting DNA synthesis and arresting cells in the S-phase of the cell cycle Its reported IC50 values approximate 1 5 mM Hydroxyurea has demonstrated potential in biomedical research settings including inhibition of HIV-1 replication in activated peripheral blood mononuclear cells (PBMCs) with an IC90 of around 0 4 mM induction of fetal hemoglobin (HbF) in erythroid cells from -thalassemia/hemoglobin E patients and tumor growth suppression in various tumor xenograft animal models when used in combination therapy regimens
Apexbio Technology LLC GLPG0634 1206161-97-8 10mM (in 1mL DMSO)
GLPG0634 (CAS 1206161-97-8) is a selective small-molecule inhibitor targeting Janus kinase 1 (JAK1) It exhibits potent inhibitory activity against JAK1 and moderate inhibition against JAK2 with reported IC50 values of approximately 10 nM and 28 nM respectively GLPG0634 preferentially interferes with signal transduction pathways mediated by JAK1 affecting cytokine-induced phosphorylation of STAT1 and STAT5 thus attenuating differentiation of Th1 Th2 and to a lesser degree Th17 cells In preclinical rat models of collagen-induced arthritis oral administration reduced inflammatory cell infiltration and bone damage supporting its potential application in inflammatory disease research