Bioactive Small Molecules
Cayman Chemical 7 S 10 S-DIHOME 5mg
An antibacterial hydroxy fatty acid; active against various food-borne pathogenic bacteria (MIC50s = 31.3-250 UG/ml), as well as various plant pathogenic bacteria (MIC90s = 125-500 UG/ml, respectively)
Cayman Chemical ANTIBODY NS 5806 5mg
An Ito current activator; increases Kv4.3-mediated Ito current amplitudes (EC50 = 5.3 µM), as well as slows Ito current decay in a KChIP2-dependent manner, in CHO-K1 cells expressing human KV4.3; increases Ito currents in isolated rabbit ventricular myocytes (EC50 = 1.6 µM); reverses rapid pacing-induced decreases in Ito current recovery and restores the spike-and-dome morphology of the epicardial action potential in ventricular wedge preparations isolated from a dog model of heart failure
Cayman Chemical ANTIBODY MW-150 5mg
An inhibitor of p38α MAPK (Ki = 101 nM); 6-, 10-, and 14-fold selective for p38α MAPK over NLK, p38β MAPK, and p38δ MAPK, respectively; selective for p38α MAPK over p38α MAPKT106M; inhibits p38α MAPK phosphorylation of MK2 in LPS-activated glia; improves spatial reference memory in the radial arm water maze in aged APP/PS1 mice
Medchemexpress LLC Drisapersen sodium | 1181666-20-5 | 98.6% | 7395.0 | C211H256N76Na19O119P19S19 | 5 MG
Drisapersen sodium is an antisense oligonucleotide that induces exon 51 skipping during dystrophin pre-mRNA splicing, enabling synthesis of partially functional dystrophin and supporting research into Duchenne muscular dystrophy. The compound is supplied as the sodium salt and is provided with batch-specific characterization for research use.
- Antisense oligonucleotide that induces exon 51 skipping.
- Suitable for Duchenne muscular dystrophy exon-skipping studies.
- Provided as the sodium salt with molecular formula and molecular weight reported.
- High purity (98.6%) for experimental consistency.
- Available in multiple research-scale package sizes.
- Certificate of analysis provided for batch-specific validation.
Cayman Chemical IsopImarIc AcId 5mg
A diterpenoid resin acid; active against clinical isolates of EMRSA (MICs = 32-64 UG/ml); an agonist of RXRα, RXRβ, and RXRγ in a reporter assay using HEK293T cells expressing human receptors (EC50s = 26, 32, and 33 µM, respectively); opens BKCa1.1/KCa1.1 in HEK293 cells expressing recombinant channels and the activating β1 regulatory subunit at 10 µM; potentiates reductions in fEPSP slopes in hippocampal slices and decreases escape latency in the Morris water maze in a 3xTg mouse model of Alzheimer's disease; has been found in pulp and paper mill effluent
Medchemexpress LLC Pkg substrate | 81187-14-6 | 99.0% | 902.01 | 10 MG
PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG). This product appears as a solid, white to off-white substance with the sequence Arg-Lys-Arg-Ser-Arg-Ala-Glu (RKRSRAE) and is intended for research use only.
- Selective for cGMP-dependent protein kinase (PKG)
- Solid, white to off-white appearance
- Sequence: Arg-Lys-Arg-Ser-Arg-Ala-Glu (RKRSRAE)
- Powder storage: -80°C for 2 years or -20°C for 1 year in sealed storage, away from moisture and light, under nitrogen
- In solvent storage: -80°C for 6 months or -20°C for 1 month in sealed storage, away from moisture and light, under nitrogen
Medchemexpress LLC Angiotensin II (3-8), human (TFA) | 99.1% | 888.93 | 10 MG
Angiotensin II (3-8), human TFA is a less effective agonist at the angiotensin AT1 receptor. This product is provided as a white to off-white solid.
- Molecular weight: 888.93
- Purity: 99.1%
- Appearance: Solid
- Soluble in H₂O at 50 mg/mL (needs ultrasonic)
- Store powder at -80°C for 2 years or -20°C for 1 year
- Store in solvent at -80°C for 6 months or -20°C for 1 month (sealed, away from moisture)
Medchemexpress LLC Prolactin Releasing Peptide (1-31), human acetate | 98.3% | 3724.17 | 5 MG
Prolactin Releasing Peptide (1-31), human (acetate) is a high affinity GPR10 ligand that causes the release of prolactin. It binds to GPR10 in humans and rats with Ki values of 1.03 nM and 0.33 nM, respectively. This peptide can be used for research related to the hypothalamo-pituitary axis.
- High affinity GPR10 ligand
- Causes the release of prolactin
- Binds to human GPR10 with a Ki of 1.03 nM
- Binds to rat GPR10 with a Ki of 0.33 nM
- Used for research of the hypothalamo-pituitary axis
- Increases plasma FSH and total plasma testosterone
- Increases LHRH release from hypothalamic explants
- Increases hypothalamic peptides (VIP and galanin) involved in pituitary hormone release
Medchemexpress LLC ACTH (1-17) TFA (α1-17-ACTH TFA) | 99.79% | 2207.43 | 10 MG
ACTH (1-17) TFA is an adrenocorticotropin analogue and a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. It exhibits high affinity for the hMC1R and can induce a slight increase in growth hormone secretion in rat pituitary cultures. In vivo studies show it inhibits DNA labeling.
- Potent human melanocortin 1 (MC1) receptor agonist
- High purity of 99.79%
- Detailed information on solubility and stock solution preparation
- Supported by published research on its biological activity
- For research use only
Medchemexpress LLC LCMV gp33-41 TFA | 98.5% | 1158.25 | 50 MG
LCMV gp33-41 (TFA), a carboxyl-extended 9-aa-long peptide, is a lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes. It is located at nucleotides 175-201 of the S segment of the LCMV genome, can be presented by the mouse MHC I molecule H-2Db and recognized by CD8+ T cells. It accumulates multiple non-synonymous mutations during chronic infection, which may help the virus evade clearance by the immune system.
- Carboxyl-extended 9-aa-long peptide
- Lymphocytic choriomeningitis virus sequence
- Restricted by MHC class I H-2Db molecules
- Presented to cytotoxic T lymphocytes
- Recognized by CD8+ T cells
- Accumulates non-synonymous mutations during chronic infection
- Supports evasion of virus clearance by the immune system
- For research use only
Selleck Chemical LLC WM-8014 2mg
WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Nigericinsodium salt 5mg
Nigericin (NSC 292567) sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as anH+, K+, and Pb2+ ionophore.Nigericin can activateNLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC JG98 2mg
JG-98 is an allosteric inhibitor ofHsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classicalapoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
![Medchemexpress LLC 4-[(5,5-dimethyl-8-quinolin-3-yl-6H-naphthalene-2-carbonyl)amino]benzoic acid | 182135-66-6 | MFCD00952209 | 99.5% | 448.50 g/mol | C29H24N2O3 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000212945.png-250.jpg)
Medchemexpress LLC 4-[(5,5-dimethyl-8-quinolin-3-yl-6H-naphthalene-2-carbonyl)amino]benzoic acid | 182135-66-6 | MFCD00952209 | 99.5% | 448.50 g/mol | C29H24N2O3 | 50 MG
A neutral, RARα-selective antagonist used as a research reagent to modulate retinoic acid receptor alpha signaling in biochemical and cell-based studies. It is supplied as a high-purity powder suitable for analytical and biological assays, with reported activity in inflammatory and angiogenic pathways and effects on cell migration and phototoxicity.
- High affinity for RARα receptor, enabling receptor-specific studies
- High purity suitable for analytical and biological assays
- Powder form allows flexible dosing and formulation
- Demonstrated modulation of inflammatory signaling pathways
- Applicable to studies of phototoxicity, angiogenesis, and cell migration
Selleck Chemical LLC Fimepinostat5mg
CUDC-907 is a dual PI3K and HDAC inhibitor for PI3K? and HDAC1/2/3/10 with IC50 of 19 nM and 1.7 nM/5 nM/1.8 nM/2.8 nM, respectively. CUDC-907 induces cell cycle arrest and apoptosis in breast cancer cells. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.