A TEAD1 inhibitor (IC50 1.02 nM) inhibits TEAD autopalmitoylation in HEK293 cells expressing TEAD1 but not HEK293 cells expressing TEAD2 TEAD3 or TEAD4 at 3 UM inhibits palmitoylation of endogenous TEAD1 in NCI-H2373 cells reduces tumor volume in NCI-H2373 and NCI H226 mesothelioma mouse xenograft models