Dimethyl Sulfoxide
Apexbio Technology LLC Dapivirine (TMC120) 244767-67-7 10mM (in 1mL DMSO)
Dapivirine (TMC120) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1 viral replication By binding directly to HIV-1 reverse transcriptase dapivirine inhibits viral RNA-dependent DNA polymerase activity thus blocking viral DNA synthesis Dapivirine demonstrates activity against HIV-1 reverse transcriptase with reported IC50 values in the low nanomolar range (approximately 1-10 nM) Due to its molecular specificity and promising in vitro antiviral profile dapivirine is widely utilized in biomedical research exploring topical prevention strategies particularly in the development of vaginal microbicides aimed at reducing HIV transmission
Apexbio Technology LLC Tadalafil 171596-29-5 10mM (in 1mL DMSO)
Tadalafil (CAS 171596-29-5) also known as IC351 is a selective inhibitor of phosphodiesterase type 5 (PDE5) a primary phosphodiesterase isoenzyme responsible for hydrolyzing cyclic guanosine monophosphate (cGMP) in pulmonary vasculature By competitively and reversibly inhibiting PDE5 tadalafil elevates intracellular cGMP levels thereby inducing vasodilation and attenuating pathological pulmonary arterial constriction Due to high selectivity tadalafil shows minimal inhibition of other PDE isoforms such as PDE1 PDE4 PDE6 PDE7 PDE8 PDE9 and PDE10 It is commonly studied in pulmonary arterial hypertension research and utilized clinically for erectile dysfunction
Apexbio Technology LLC Forskolin 66575-29-9 10mM (in 1mL DMSO)
Forskolin (CAS 66575-29-9) is a diterpenoid isolated from the plant Coleus forskohlii known to directly activate adenylate cyclase type I thereby elevating cellular cyclic AMP (cAMP) concentrations It exhibits an IC50 of approximately 41 nM against adenylate cyclase By increasing intracellular cAMP forskolin modulates signaling pathways involved in inflammation and oxidative stress reducing macrophage activation and subsequent production of thromboxane B2 and superoxide Forskolin has been explored in various experimental models and clinical contexts including cardiovascular disorders diabetes mellitus and asthma research
Apexbio Technology LLC Piceatannol 10083-24-6 10mM (in 1mL DMSO)
Piceatannol (CAS 10083-24-6) is a naturally occurring small molecule exhibiting anti-inflammatory immunomodulatory and antiproliferative activities It functions primarily by inhibiting protein tyrosine kinases including p56lck and syk kinases and suppressing tumor necrosis factor (TNF)-induced nuclear factor-kappa B (NF- B) activation and downstream gene expression Biologically piceatannol arises as a metabolite of resveratrol through oxidation by cytochrome P450 1B1 This compound is employed in biomedical research to explore kinase signaling pathways inflammatory response regulation and potential therapeutic interventions
Apexbio Technology LLC Kaempferol(Synonyms: Kempferol, Kaempherol, Kaempferide, Robigenin, Rhamnolutein, Populnetin), 10mM (in 1mL DMSO), CAS: 520-18-3.
Kaempferol (CAS 520-18-3) is a naturally derived flavonoid isolated from sources including Gingko biloba and red wine It functions biologically by activating the mitochondrial calcium uniporter (EC50 7 M) Additionally kaempferol promotes apoptosis through the caspase-9 pathway by suppressing polo-like kinase 1 (PLK1) expression thereby inhibiting cancer cell proliferation in diverse cell lines It also demonstrates antioxidant properties and reduces osteoclast-mediated bone resorption in vitro These characteristics make kaempferol valuable for researching mitochondrial physiology cancer biology and bone metabolism
Medchemexpress LLC Ro4929097 10 Mm / 1 Ml In Dmso | HY-11102-10MM/1ML IN DMSO
Ro4929097 10 Mm / 1 Ml In Dmso
Apexbio Technology LLC Prilocaine 721-50-6 10mM (in 1mL DMSO)
Prilocaine (CAS 721-50-6) is a local anesthetic molecule categorized within the amino amide class Its primary pharmacological mechanism involves reversible blockade of voltage-gated sodium channels in neuronal membranes thereby inhibiting action potential propagation and sensory nerve impulse conduction Due to its sodium channel-blocking profile prilocaine is commonly investigated in biomedical research examining reversible neural inhibition pain modulation pathways and sensory signal transmission mechanisms
Apexbio Technology LLC PD123319 130663-39-7 10mM (in 1mL DMSO)
PD123319 (CAS 130663-39-7) is a non-peptide antagonist targeting angiotensin II (Ang II) receptors particularly the AT2 receptor subtype It binds selectively exhibiting an IC50 of 34 nM in rat adrenal assays and 210 nM in rat brain binding assays Additionally PD123319 inhibits Ang II binding to bovine adrenal glomerulosa microsomal preparations with an IC50 of 6 9 nM Its antagonistic activity leads to reduced cyclic GMP synthesis and elevated prostaglandin E2 production without altering protein tyrosine phosphorylation or thymidine incorporation mediated by Ang II PD123319 serves as a useful pharmacological tool in investigating Ang II receptor signaling pathways
Apexbio Technology LLC SB 431542 301836-41-9 10mM (in 1mL DMSO)
SB 431542 (CAS number 301836-41-9) is a selective ATP-competitive inhibitor targeting activin receptor-like kinase 5 (ALK5) a type I receptor within the transforming growth factor- (TGF- ) signaling pathway It inhibits ALK5 activity with an IC50 value of 94 nM thereby preventing phosphorylation of Smad2 proteins and their subsequent nuclear accumulation Additionally SB 431542 inhibits closely related receptors ALK4 and ALK7 while showing minimal or no significant activity against ALK1 ALK2 ALK3 and ALK6 at relevant concentrations Commonly utilized in cellular assays to investigate TGF- signaling this compound is valuable for studying associated cellular processes and diseases
Apexbio Technology LLC Carvedilol 72956-09-3 10mM (in 1mL DMSO)
Carvedilol is an antagonist targeting 1- and -adrenergic receptors employed in research on cardiovascular diseases especially congestive heart failure and hypertension Mechanistically carvedilol blocks adrenergic receptor-mediated signaling influencing sympathetic nervous system activity Additionally carvedilol exhibits antioxidative properties in vitro studies demonstrate suppression of Fe2 -induced lipid peroxidation (IC50 8 1 M) protection of -tocopherol depletion due to Fe2 exposure (IC50 17 6 M) and reduction of hydroxyl radical-derived DMPO-OH signals (IC50 25 M) It also inhibits proliferation (IC50 0 3-2 0 M) and migration (IC50 3 M) in vascular smooth muscle cells induced by platelet-derived growth factor supporting investigation of vascular remodeling processes
Apexbio Technology LLC (-)-MK 801 121917-57-5 10mM (in 1mL DMSO)
(-)-MK 801 (CAS 121917-57-5) is a small molecule serving as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor It crosses the blood-brain barrier binding reversibly and with high affinity to cortical membranes in a saturable regionally specific manner notably within the hippocampus (-)-MK 801 selectively inhibits depolarization responses to NMDA receptor activation leading to suppression of seizure-like neuronal activity induced by neurotoxins such as tetrodotoxin Due to these properties it has widespread use as a research tool in neuroscience particularly in investigating excitotoxicity epilepsy and neurological disorders associated with NMDA receptor dysfunction
Apexbio Technology LLC CX-4945 (Silmitasertib) 1009820-21-6 10mM (in 1mL DMSO)
CX-4945 (Silmitasertib CAS 1009820-21-6) is an orally bioavailable inhibitor targeting casein kinase 2 (CK2) via ATP-competitive binding with an IC50 of approximately 1 nM It suppresses CK2-mediated signaling pathways notably by reducing phosphorylation of Akt at Ser129 independently of PTEN activation thus impacting PI3K/Akt pathway regulation In vitro studies report that CX-4945 treatment leads to increased total expression and decreased phosphorylation of cell cycle regulators p21 and p27 causing cell cycle arrest (G2/M in BT-474 breast carcinoma G1 in BxPC-3 pancreatic carcinoma) In vivo it displays antitumor activity in BxPC-3 mouse xenograft models highlighting its utility for oncology research
Apexbio Technology LLC SGC-CBP30 1613695-14-9 10mM (in 1mL DMSO)
SGC-CBP30 (CAS 1613695-14-9) is a selective small-molecule inhibitor targeting the bromodomains of CREB-binding protein (CREBBP) and E1A-binding protein p300 (EP300) exhibiting IC50 values of 21 nM and 38 nM respectively Both EP300 and CREBBP function as transcriptional coactivators involved in diverse regulatory processes including cell proliferation differentiation and transcription factor activation Through its inhibitory action SGC-CBP30 is utilized widely in biomedical research to investigate the molecular roles of CREBBP/EP300 as well as in studies examining related signaling pathways in tumor biology and cellular regulation
Supply Solutions Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML
Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML