Dimethyl Sulfoxide
Apexbio Technology LLC Preladenant 377727-87-2 10mM (in 1mL DMSO)
Preladenant is a potent and selective antagonist targeting the adenosine A2A receptor (Ki 1 1 nM) developed from structural modifications of SCH 58261 Structurally it is a methoxy derivative carrying enhanced affinity and selectivity towards human and rat A2A receptors over A1 A2B and A3 subtypes Mechanistically Preladenant competitively blocks A2A receptor-mediated adenylate cyclase activation In preclinical studies Preladenant reduces Parkinsonian symptoms in primate and rodent models alone or in combination with L-Dopa thus widely employed in experimental research for Parkinson s disease and associated movement disorders
Apexbio Technology LLC Chlorothiazide 58-94-6 10mM (in 1mL DMSO)
Chlorothiazide is a sulfonamide-derived diuretic compound known for its inhibitory action on carbonic anhydrase enzymes It functions by reducing sodium and chloride ion reabsorption via blockade of renal tubular transport mechanisms which subsequently promotes increased urine output Structurally Chlorothiazide contains a benzothiadiazine ring system contributing to its specific interaction with renal transport channels and carbonic anhydrase enzymes In biomedical research Chlorothiazide serves as a pharmacological tool to investigate ion transport pathways renal physiologic processes and mechanisms underlying fluid balance regulation Additionally it is utilized in experimental models studying electrolyte homeostasis and disorders associated with abnormal sodium or chloride retention
Apexbio Technology LLC EHT 1864(Synonyms: EHT-1864, EHT1864, RAC inhibitor EHT1864, Rac GTPase inhibitor EHT 1864), 10mM (in 1mL DMSO), CAS: 754240-09-0.
EHT 1864 (CAS 754240-09-0) is a small-molecule inhibitor targeting Rac family GTPases with strongest affinity and inhibitory activity toward Rac1 It interacts directly with Rac isoforms Rac1 Rac1b Rac2 and Rac3 exhibiting Kd values of approximately 40 nM 50 nM 60 nM and 250 nM respectively By disrupting nucleotide binding EHT 1864 blocks Rac1 activation and prevents the formation of active Rac1/PAK-RBD complexes thus inhibiting downstream cellular functions such as PDGF-stimulated lamellipodia formation and Rac1-mediated cellular transformation This compound serves as a valuable tool in cell biology research for studying Rac-dependent signaling pathways and cellular dynamics
Apexbio Technology LLC KPT-330 1393477-72-9 10mM (in 1mL DMSO)
KPT-330 (CAS 1393477-72-9) is an orally bioavailable small-molecule inhibitor selectively targeting chromosome region maintenance 1 protein (CRM1) a nuclear export receptor involved in the active transport of tumor suppressors transcription factors and cell-cycle regulators Overexpression and deregulation of CRM1 are frequently associated with cancer progression KPT-330 inhibits CRM1 function promoting nuclear retention of regulatory proteins such as p21 and inducing apoptosis through activation of apoptotic signaling pathways (e g PAR-4 activation Bax upregulation PARP cleavage caspase-3 activation) In preclinical studies KPT-330 demonstrated antitumor activity against renal cell carcinoma non-small cell lung cancer and pancreatic cancer models
Apexbio Technology LLC Tiplaxtinin(PAI-039)(Synonyms: Tiplaxtinin, PAI-039, Tiplaxtinin (PAI-039), Tiplaxitin, PAI1 inhibitor, PAI-1 antagonist, RWJ-676070), 10mM (in 1mL DMSO), CAS: 393105-53-8.
Tiplaxtinin (PAI-039 CAS 393105-53-8) is an orally bioavailable small molecule inhibitor targeting plasminogen activator inhibitor-1 (PAI-1) a physiological regulator of the plasminogen activation system Elevated PAI-1 levels stabilize thrombi by inhibiting tissue- and urokinase-type plasminogen activators Tiplaxtinin binds selectively to PAI-1 with a Kd of approximately 480 nM and inhibits its activity with an IC50 value around 2 7 M In animal models oral administration of Tiplaxtinin significantly delayed arterial thrombus-induced occlusion supporting its utility as a research tool for studying fibrinolytic pathways and thrombotic disorders
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
Apexbio Technology LLC Riociguat 625115-55-1 10mM (in 1mL DMSO)
Riociguat (CAS 625115-55-1) chemically known as BAY 63-2521 is a small-molecule stimulator of soluble guanylate cyclase (sGC) It directly activates sGC independently and also enhances the enzyme s sensitivity to nitric oxide (NO) leading to elevated cyclic guanosine monophosphate (cGMP) levels Elevated cGMP induces smooth muscle relaxation and vasodilation Riociguat has been examined clinically for potential therapeutic roles in chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH)
Apexbio Technology LLC P005091 882257-11-6 10mM (in 1mL DMSO)
P005091 (CAS 882257-11-6) is an inhibitor that selectively targets the ubiquitin-specific protease 7 (USP7) also known as herpes-associated ubiquitin-specific protease (HAUSP) By blocking USP7-mediated deubiquitination P005091 promotes degradation of HDM2 resulting in altered regulation of downstream targets including increased cellular levels of tumor suppressor proteins p53 and p21 Through USP7 inhibition P005091 can downregulate claspin and suppress phosphorylation of DNA checkpoint kinase Chk1 enhancing genotoxic drug sensitivity and inducing apoptosis in cancer cell lines irrespective of p53 mutational status This makes P005091 relevant as a research probe for studying USP7-dependent signaling pathways and cancer cell biology
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 10mL
Dimethyl sulfoxide (DMSO) meets analytical specification of Ch P is an aprotic solvent that dissolves polar and non-polar compounds including water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties[1][2][3] br/ MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition) Amicrobic low endotoxin can be used in various biochemical experiments such as drug dissolution
Apexbio Technology LLC Alexidine dihydrochloride 1715-30-6 10mM (in 1mL DMSO)
Alexidine dihydrochloride is a selective inhibitor targeting mitochondrial protein tyrosine phosphatase 1 (PTPMT1) exhibiting inhibitory activity with an IC50 value of approximately 1 08 M in vitro By inhibiting PTPMT1 Alexidine dihydrochloride modulates mitochondrial signaling pathways implicated in cellular metabolism Additionally this compound enhances insulin secretion in pancreatic -cells of rat islet models In cancer biology research Alexidine dihydrochloride demonstrates activity against FaDu cells providing a relevant tool for studying mitochondrial phosphatase-mediated mechanisms in oncology and diabetes-related research applications
Apexbio Technology LLC Chlorpromazine HCl 69-09-0 10mM (in 1mL DMSO)
Chlorpromazine HCl (CAS 69-09-0) is a phenothiazine-based dopamine receptor antagonist with significant activity at G protein-coupled dopamine receptors in the central nervous system Mechanistically chlorpromazine directly binds to dopamine receptors competitively inhibiting receptor-ligand interactions as evidenced by its inhibition of [ H]spiperone binding in vitro In vivo studies indicate chronic chlorpromazine administration in rats induces behavioral sensitization and altered motor responses linked to DA and NMDA receptor function Clinically chlorpromazine is established as a conventional antipsychotic approved for schizophrenia treatment making it valuable in neuropharmacology research
Apexbio Technology LLC LY364947 396129-53-6 10mM (in 1mL DMSO)
LY364947 (CAS 396129-53-6) is a selective inhibitor targeting the kinase domain of transforming growth factor- (TGF- ) type I receptor TGF- signaling regulates crucial biological processes such as cell proliferation differentiation and tissue homeostasis In vitro studies demonstrated that LY364947 inhibits the receptor kinase activity with an IC50 of 51 nM effectively suppressing TGF- -dependent luciferase activity in mink lung epithelial cells (p3TP Lux assay) and growth of NIH 3T3 fibroblasts In vivo LY364947 showed protective effects against NMDA-induced retinal degeneration in rats attenuating retinal ganglion cell loss and capillary degradation Thus LY364947 serves as a valuable pharmacological tool in TGF- -related research and associated pathological conditions
Apexbio Technology LLC Acetaminophen 103-90-2 10mM (in 1mL DMSO)
Acetaminophen (paracetamol) is a cyclooxygenase-2 (COX-2) inhibitor widely employed in biomedical studies for investigating analgesic and antipyretic mechanisms Its inhibition of COX-2 enzyme activity occurs with an IC50 of approximately 25 8 M Experimental use includes inducing cellular hepatotoxicity models where acetaminophen exposure triggers glutathione depletion impaired glutathione peroxidase activity and ferroptosis-mediated cell death This makes acetaminophen useful in examining oxidative stress hepatic cell injury and associated cellular response mechanisms in vitro and in animal studies Additionally acetaminophen-mediated toxicity is applicable in screening protective agents or evaluating ferroptosis inhibitors in pharmacological research